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  • Therapeutic targeting of TE... Therapeutic targeting of TEAD transcription factors in cancer
    Pobbati, Ajaybabu V.; Kumar, Ramesh; Rubin, Brian P. ... Trends in biochemical sciences (Amsterdam. Regular ed.), 20/May , Volume: 48, Issue: 5
    Journal Article
    Peer reviewed

    TEAD transcription factors pair with YAP and TAZ to orchestrate various transcriptional programs of cell proliferation and cell death suppression that promote cancer development.The structure of TEAD ...
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  • Protein-Protein Interaction... Protein-Protein Interaction Disruptors of the YAP/TAZ-TEAD Transcriptional Complex
    Pobbati, Ajaybabu V; Rubin, Brian P Molecules (Basel, Switzerland), 12/2020, Volume: 25, Issue: 24
    Journal Article
    Peer reviewed
    Open access

    The identification of protein-protein interaction disruptors (PPIDs) that disrupt the YAP/TAZ-TEAD interaction has gained considerable momentum. Several studies have shown that YAP/TAZ are no longer ...
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  • Measures of promptness of c... Measures of promptness of cancer diagnosis in primary care: secondary analysis of national audit data on patients with 18 common and rarer cancers
    LYRATZOPOULOS, G; ABEL, G. A; MCPHAIL, S ... British journal of cancer, 02/2013, Volume: 108, Issue: 3
    Journal Article
    Peer reviewed
    Open access

    Evidence is needed about the promptness of cancer diagnosis and associations between its measures. We analysed data from the National Audit of Cancer Diagnosis in Primary Care 2009-10 exploring the ...
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  • Carotenoid Lutein Selective... Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms
    Gong, Xiaoming; Smith, Joshua R; Swanson, Haley M ... Molecules (Basel, Switzerland), 04/2018, Volume: 23, Issue: 4
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    Open access

    Increasing evidence suggests that dietary carotenoids may reduce the risk of breast cancer. However, anti-breast cancer effects of carotenoids have been controversial, albeit understudied. Here, we ...
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  • Sox10: a pan-schwannian and melanocytic marker
    Nonaka, Daisuke; Chiriboga, Luis; Rubin, Brian P The American journal of surgical pathology, 09/2008, Volume: 32, Issue: 9
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    S100 protein is a sensitive marker for melanomas and peripheral nerve sheath tumors. It is, however, expressed by other mesenchymal and epithelial tumors. Despite its low specificity, S100 protein is ...
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  • Symptom Signatures and Diag... Symptom Signatures and Diagnostic Timeliness in Cancer Patients: A Review of Current Evidence
    Koo, Minjoung M.; Hamilton, William; Walter, Fiona M. ... Neoplasia, 02/2018, Volume: 20, Issue: 2
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    Open access

    Early diagnosis is an important aspect of contemporary cancer prevention and control strategies, as the majority of patients are diagnosed following symptomatic presentation. The nature of presenting ...
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  • Alpha to Omicron: Disease S... Alpha to Omicron: Disease Severity and Clinical Outcomes of Major SARS-CoV-2 Variants
    Esper, Frank P; Adhikari, Thamali M; Tu, Zheng Jin ... The Journal of infectious diseases, 02/2023, Volume: 227, Issue: 3
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    Four severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants predominated in the United States since 2021. Understanding disease severity related to different SARS-CoV-2 variants ...
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  • Functional Enhancers Shape ... Functional Enhancers Shape Extrachromosomal Oncogene Amplifications
    Morton, Andrew R.; Dogan-Artun, Nergiz; Faber, Zachary J. ... Cell, 11/2019, Volume: 179, Issue: 6
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    Open access

    Non-coding regions amplified beyond oncogene borders have largely been ignored. Using a computational approach, we find signatures of significant co-amplification of non-coding DNA beyond the ...
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  • Mechanism of action of a WW... Mechanism of action of a WWTR1(TAZ)-CAMTA1 fusion oncoprotein
    Tanas, M R; Ma, S; Jadaan, F O ... Oncogene, 02/2016, Volume: 35, Issue: 7
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    The WWTR1 (protein is known as TAZ)-CAMTA1 (WC) fusion gene defines epithelioid hemangioendothelioma, a malignant vascular cancer. TAZ (transcriptional coactivator with PDZ binding motif) is a ...
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