We present a new synthesis, based on a suite of complementary approaches, of the primary production and carbon sink in forests of the 25 member states of the European Union (EU-25) during 1990-2005. ...Upscaled terrestrial observations and model-based approaches agree within 25% on the mean net primary production (NPP) of forests, i.e. 520±75 g C m⁻² yr⁻¹ over a forest area of 1.32 x 10⁶ km² to 1.55 x 10⁶ km² (EU-25). New estimates of the mean long-term carbon forest sink (net biome production, NBP) of EU-25 forests amounts 75±20 g C m⁻² yr⁻¹. The ratio of NBP to NPP is 0.15±0.05. Estimates of the fate of the carbon inputs via NPP in wood harvests, forest fires, losses to lakes and rivers and heterotrophic respiration remain uncertain, which explains the considerable uncertainty of NBP. Inventory-based assessments and assumptions suggest that 29±15% of the NBP (i.e., 22 g C m⁻² yr⁻¹) is sequestered in the forest soil, but large uncertainty remains concerning the drivers and future of the soil organic carbon. The remaining 71±15% of the NBP (i.e., 53 g C m⁻² yr⁻¹) is realized as woody biomass increments. In the EU-25, the relatively large forest NBP is thought to be the result of a sustained difference between NPP, which increased during the past decades, and carbon losses primarily by harvest and heterotrophic respiration, which increased less over the same period.
The growth rate of atmospheric CO₂ exhibits large temporal variation that is largely determined by year-to-year fluctuations in land-atmosphere CO₂ fluxes. This land-atmosphere CO₂-flux is driven by ...large-scale biomass burning and variation in net ecosystem exchange (NEE). Between- and within years, NEE varies due to fluctuations in climate. Studies on climatic influences on inter- and intra-annual variability in gross photosynthesis (GPP) and net carbon uptake in terrestrial ecosystems have shown conflicting results. These conflicts are in part related to differences in methodology and in part to the limited duration of some studies. Here, we introduce an observation-driven methodology that provides insight into the dependence of anomalies in CO₂ fluxes on climatic conditions. The methodology was applied on fluxes from a boreal and two temperate pine forests. Annual anomalies in NEE were dominated by anomalies in GPP, which in turn were correlated with incident radiation and vapor pressure deficit (VPD). At all three sites positive anomalies in NEE (a reduced uptake or a stronger source than the daily sites specific long-term average) were observed on summer days characterized by low incident radiation, low VPD and high precipitation. Negative anomalies in NEE occurred mainly on summer days characterized by blue skies and mild temperatures. Our study clearly highlighted the need to use weather patterns rather than single climatic variables to understand anomalous CO₂ fluxes. Temperature generally showed little direct effect on anomalies in NEE but became important when the mean daily air temperature exceeded 23 °C. On such days GPP decreased likely because VPD exceeded 2.0 kPa, inhibiting photosynthetic uptake. However, while GPP decreased, the high temperature stimulated respiration, resulting in positive anomalies in NEE. Climatic extremes in summer were more frequent and severe in the South than in the North, and had larger effects in the South because the criteria to inhibit photosynthesis are more often met.
Summary Background The genetic cause of amyotrophic lateral sclerosis (ALS) is not well understood. Finland is a well suited location for a genome-wide association study of ALS because the incidence ...of the disease is one of the highest in the world, and because the genetic homogeneity of the Finnish population enhances the ability to detect risk loci. We aimed to identify genetic risk factors for ALS in the Finnish population. Methods We did a genome-wide association study of Finnish patients with ALS and control individuals by use of Illumina genome-wide genotyping arrays. DNA was collected from patients who attended an ALS specialty clinic that receives referrals from neurologists throughout Finland. Control samples were from a population-based study of elderly Finnish individuals. Patients known to carry D90A alleles of the SOD1 gene (n=40) were included in the final analysis as positive controls to assess whether our genome-wide association study was able to detect an association signal at this locus. Findings We obtained samples from 442 patients with ALS and 521 control individuals. After quality control filters were applied, 318 167 single nucleotide polymorphisms (SNPs) from 405 people with ALS and 497 control individuals were available for analysis. We identified two association peaks that exceeded genome-wide significance. One was located on chromosome 21q22 (rs13048019, p=2·58×10−8 ), which corresponds to the autosomal recessive D90A allele of the SOD1 gene. The other was detected in a 232 kb block of linkage disequilibrium (rs3849942, p=9·11×10−11 ) in a region of chromosome 9p that was previously identified in linkage studies of families with ALS. Within this region, we defined a 42-SNP haplotype that was associated with significantly increased risk of ALS (p=7·47×10−33 when people with familial ALS were compared with controls, odds ratio 21·0, 95% CI 11·2–39·1) and which overlapped with an association locus recently reported for frontotemporal dementia. For the 93 patients with familial ALS, the population attributable risk for the chromosome 9p21 locus was 37·9% (95% CI 27·7–48·1) and that for D90A homozygosity was 25·5% (16·9–34·1). Interpretation The chromosome 9p21 locus is a major cause of familial ALS in the Finnish population. Our data suggest the presence of a founder mutation for chromosome 9p21-linked ALS. Furthermore, the overlap with the risk haplotype recently reported for frontotemporal dementia provides further evidence of a shared genetic cause for these two neurodegenerative diseases. Funding National Institutes of Health and National Institute on Aging, Microsoft Research, ALS Association, Helsinki University Central Hospital, Finnish Academy, Finnish Medical Society Duodecim, and Kuopio University.
OBJECTIVES: To investigate the association between blood pressure and mortality in people aged 85 and older.
DESIGN: Population‐based prospective study with 9‐year follow‐up.
SETTING: Department of ...Neuroscience and Neurology and Department of Public Health and General Practice, University of Kuopio, and Department of Clinical Neurosciences, Helsinki University Hospital.
PARTICIPANTS: Of all 601 people living in the city of Vantaa born before the April 1, 1906, whether living at home or in institutions and alive on April 1, 1991, 521 were clinically examined and underwent blood pressure measurement.
MEASUREMENTS: Blood pressure was measured using a standardized method in the right arm of the subject after resting for at least 5 minutes. Information on medical history for each participant was verified from a computerized database containing all primary care health records. Death certificates were obtained from the National Register; the collection of death certificates was complete.
RESULTS: After adjusting for age, sex, functional status, and coexisting diseases (earlier‐diagnosed myocardial infarction, congestive heart failure, dementia, cancer, stroke, or hypertension), low systolic blood pressure (BP) was associated with risk of death.
CONCLUSION: Low systolic BP may be partially related to poor general health and poor vitality, but the very old may represent a select group of individuals, and the use of BP‐lowering medications needs to be evaluated in this group.
Data from a large-scale foliar survey were used to calculate the extent to which N and S deposition determined the mineral composition of Scots pine and Norway spruce needles in Finland. Foliar data ...were available from 367 needle samples collected on 36 plots sampled almost annually between 1987 and 2000. A literature study of controlled experiments revealed that acidifying deposition mediates increasing N and S concentrations, and decreasing Mg:N and Ca:Al ratios in the needles. When this fingerprint for N and S elevated deposition on tree foliage was observed simultaneously with increased N and S inputs, it was considered sufficient evidence for assuming that acidifying deposition had altered the mineral composition of tree needles on that plot in the given year. Evidence for deposition-induced changes in the mineral composition of tree foliage was calculated on the basis of a simple frequency model. In the late eighties the evidence was found on 43% of the Norway spruce and 27% of Scots pine plots. The proportion of changed needle mineral composition decreased to below 8% for both species in the late nineties.
The mineral composition of needles no longer provides evidence to support the widespread onset of N saturation or acidification problems in Finnish forests.
Analyzing and predicting the development of foliar nutrient concentrations are important and challenging tasks in environmental monitoring. This article presents how linear sparse regression models ...can be used to represent the relations between different foliar nutrient concentration measurements of coniferous trees in consecutive years. In the experiments the models proved to be capable of providing relatively good and reliable predictions of the development of foliage with a considerably small number of regressors. Two methods for estimating sparse models were compared to more conventional linear regression models. Differences in the prediction accuracies between the sparse and full models were minor, but the sparse models were found to highlight important dependencies between the nutrient measurements better than the other regression models. The use of sparse models is, therefore, advantageous in the analysis and interpretation of the development of foliar nutrient concentrations.
Pain is often underrecognized and undertreated among older people. However, older people may be particularly susceptible to adverse drug reactions linked to prescription and nonprescription ...analgesics.
The aims of this study were to assess the prevalence of analgesic use among a random sample of community-dwelling people aged >or=75 years, and to investigate factors associated with daily and as-needed analgesic use.
A random sample of people aged >or=75 years was drawn from the population register in Kuopio, Finland, in November 2003. Data on prescription and nonprescription analgesic use were elicited during nurse interviews conducted once for each participant in 2004. Self-reported drug utilization data were verified against medical records. The interview included items pertaining to sociodemographic factors, living conditions, social contacts, health behavior, and state of health. Physical function was assessed using the Instrumental Activities of Daily Living Scale, and the 10-item Barthel Index. Self-rated mobility was assessed by asking whether respondents could walk 400 meters (yes, yes with difficulty but without help, not without help, or no). Cognitive function was assessed using the Mini-Mental State Examination. The presence of depressive symptoms was assessed using the 15-item Geriatric Depression Scale. Respondents' self-rated health was determined using a 5-point scale (very poor, poor, moderate, good, or very good).
Of the initial random sample of participants (N = 1000), 700 provided consent to participate and were community dwelling. Among the participants, 318 (45.4%) were users of >or=1 analgesic on a daily or as-needed basis. Only 23.3% of analgesic users took an analgesic on a daily basis. Factors associated with any analgesic use included female sex (odds ratio OR, 1.78 95 degrees % CI, 1.17-2.71), living alone (OR, 1.46 95 degrees % CI, 1.02-2.11), poor self-rated health (OR, 2.6 95% CI, 1.22-3.84), and use of >or=10 nonanalgesic drugs (OR, 2.21 95% CI, 1.26-3.87). Among users of >or=1 oral analgesic, factors associated with opioid use included moderate (OR, 2.46 95% CI, 1.175.14) and poor (OR, 2.57 95% CI, 1.03-6.42) self-rated health. Opioid use (OR, 0.19 95% CI, 0.04-0.86) and daily analgesic use (OR, 0.16 95% CI, 0.34-0.74) were inversely associated with depressive symptoms. Pain in the previous month was reported by 71.4% of analgesic users and 26.4% of nonusers of analgesics.
Analgesics were used by approximately 50% of community-dwelling people aged >or=75 years. However, age was not significantly associated with increased use of analgesics in multivariate analysis. The majority of analgesic drugs were used on an as-needed rather than a daily basis (76.7% vs 23.3%, respectively). Factors most significantly associated with analgesic use were female sex, living alone, poor self-rated health, and use of >or=10 nonanalgesic drugs.
LETTERS TO THE EDITOR Rastas, Sari; Tuula Pirttilä, MD, PhD; Petteri Viramo, MD, PhD ...
Journal of the American Geriatrics Society (JAGS),
01/2007, Volume:
55, Issue:
1
Journal Article
This paper introduces the use of nutrition profiles as a first step in the development of a concept that is suitable for evaluating forest nutrition on the basis of large-scale foliar surveys. ...Nutrition profiles of a tree or stand were defined as the nutrient status, which accounts for all element concentrations, contents and interactions between two or more elements. Therefore a nutrition profile overcomes the shortcomings associated with the commonly used concepts for evaluating forest nutrition. Nutrition profiles can be calculated by means of a neural network, i.e. a self-organizing map, and an agglomerative clustering algorithm with pruning. As an example, nutrition profiles were calculated to describe the temporal variation in the mineral composition of Scots pine and Norway spruce needles in Finland between 1987 and 2000. The temporal trends in the frequency distribution of the nutrition profiles of Scots pine indicated that, between 1987 and 2000, the N, S, P, K, Ca, Mg and Al decreased, whereas the needle mass (NM) increased or remained unchanged. As there were no temporal trends in the frequency distribution of the nutrition profiles of Norway spruce, the mineral composition of the needles of Norway spruce needles subsequently did not change. Interpretation of the (lack of) temporal trends was outside the scope of this example. However, nutrition profiles prove to be a new and better concept for the evaluation of the mineral composition of large-scale surveys only when a biological interpretation of the nutrition profiles can be provided.
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