J-PARC is one of the world's highest-intensity proton synchrotron facilities for material and life sciences, neutrino physics, hadron and nuclear physics. By acceleration of heavy-ion beams, J-PARC ...could also become a high-intensity frontier heavy-ion beam facility (J-PARC-HI). For heavy-ion acceleration, we will build a heavy-ion linac and a booster ring as a compact heavy-ion injector, while we utilize the existing RCS and MR synchrotrons to accelerate 1011 Hz heavy-ion beams at 1–12 AGeV/c. We aim at exploring phase structures of the QCD phase diagram in a high baryon-density regime such as the first-order phase boundary and the QCD critical point, and also aim to search for multi-strangeness systems. We are developing the experimental design for a large acceptance spectrometer. In this work, physics feasibility of J-PARC-HI such as flow and hypernucleus measurements will be shown. Also, a plan to transport heavy-ion beams in the primary proton beamline at Hadron Experimental Facility and an upgrade plan to study heavy-ion collisions at the p+A experiment J-PARC E16 will be presented.
In J-PARC heavy-ion project, we aim at studies of QCD phase structures and hadron properties in high baryon density close to the neutron star core. We have developed a heavy-ion acceleration scheme ...with a new linac and a new booster with existing two synchrotrons with the goal beam rate of about 1011 Hz. We have also designed a large acceptance spectrometer based on a toroidal magnet. We have evaluated the spectrometer performance, and demonstrated reconstructing dielectron and dimuon spectra with full detector simulations. Finally, we designed a hypernuclear spectrometer which can utilize the full intensity ion beams.
We have developed a gas electron multiplier (GEM)-based time projection chamber (TPC) for the H-dibaryon search experiment at J-PARC. High-rate K− beam particles enter a TPC gas volume of ...approximately 0.2 m3, in a direction perpendicular to the electric field. A long-rectangular hollow section is located inside the TPC volume to accommodate a diamond target. We commissioned the TPC using 230-MeV protons with beam rates of up to 1 MHz. The TPC data acquisition system collected 5768 pad signals in full readout mode, with almost 100% efficiency, at a preset trigger rate of 230 Hz. We operated the TPC in an Ar/CH4 gas mixture (90/10) without a magnetic field. The spatial resolutions on the pad plane are measured to be 400–700μm, which correspond to 230–300μm in a magnetic field of 1 T. We confirmed high tracking capability at beam rates of up to 1 MHz.
Abstract Background Hyperuricemia is a common adverse event frequently found in renal transplant recipients with mizoribine (MZ). Hyperuricemia itself will be a cause of renal dysfunction, and renal ...dysfunction also will be a cause of hyperuricemia simultaneously. This study investigates frequency of hyperuricemia and renal failure in renal transplant recipients treated with high-dose MZ. Patients and Methods From December 2007 to October 2015, there was a total of 32 living related renal transplant recipients treated with high-dose MZ. Of the 32 patients, 28 were treated with urate-lowering medications. Results One patient received allopurinol (AP) and 13 patients received benzbromarone (BB). For 6 of them, their urate-lowering medications were converted to febuxostat (FX) form AP or BB. In the remaining 14 patients, FX was administered from the beginning. In 2 cases of ABO-incompatible living related renal transplant recipients who were maintained with high-dose MZ and BB, severe hyperuricemia and acute renal failure occurred. One patient was a 48-year-old man, and his creatinine (Cr) level increased to 8.14 mg/dL and his serum uric acid (UA) was 24.6 mg/dL. Another patient was a 57-year-old man, and his Cr level increased to 3.59 mg/dL and his UA was 13.2 mg/dL. In both cases Cr and UA were improved, and no finding of acute rejection and drug toxicity was observed in graft biopsy specimens. BB was switched to FX and discontinuance or reduction of MZ was done. Conclusion Combination of MZ and BB has the risk of acute renal dysfunction after renal transplantation. Latent renal dysfunction should be watched for in renal transplant recipients receiving high-dose MZ.
In integrated segmentation and recognition of character strings, the underlying classifier is trained to be resistant to noncharacters. We evaluate the performance of state-of-the-art pattern ...classifiers of this kind. First, we build a baseline numeral string recognition system with simple but effective presegmentation. The classification scores of the candidate patterns generated by presegmentation are combined to evaluate the segmentation paths and the optimal path is found using the beam search strategy. Three neural classifiers, two discriminative density models, and two support vector classifiers are evaluated. Each classifier has some variations depending on the training strategy: maximum likelihood, discriminative learning both with and without noncharacter samples. The string recognition performances are evaluated on the numeral string images of the NIST special database 19 and the zipcode images of the CEDAR CDROM-1. The results show that noncharacter training is crucial for neural classifiers and support vector classifiers, whereas, for the discriminative density models, the regularization of parameters is important. The string recognition results compare favorably to the best ones reported in the literature though we totally ignored the geometric context. The best results were obtained using a support vector classifier, but the neural classifiers and discriminative density models show better trade-off between accuracy and computational overhead.
A high statistics ∑p scattering experiment has been performed at the K1.8 beamline in the J-PARC Hadron Experimental Facility. Data for momentum-tagged ∑− beam running in a liquid hydrogen target ...were accumulated by detecting the π−p→K+∑− reaction with a high intensity π− beam of 20 M/spill. The number of the Σ− beam was about 1.7 × 107 in total. The ∑−ρ elastic scattering and the ∑−p → Λn inelastic scattering events were successfully observed with about 100 times larger statistics than that in past experiments.
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