Several studies have suggested functional association between μ‐opioid and δ‐opioid receptors and showed that μ‐activity could be modulated by δ‐ligands. The general conclusion is that agonists for ...the δ‐receptor can enhance the analgesic potency and efficacy of μ‐agonists. Our preliminary investigations demonstrate that new bivalent ligands constructed from the μ‐agonist fentanyl and the δ‐agonist enkephalin‐like peptides are promising entities for creation of new analgesics with reduced side effects for treatment of neuropathic pain. A new superposition of the mentioned pharmacophores led to novel μ‐bivalent/δ‐bivalent compounds that demonstrate both μ‐opioid and δ‐opioid receptor agonist activity and high efficacy in anti‐inflammatory and neuropathic pain models with the potential of reduced unwanted side effects.
We present measurements of π(-) and π(+) elliptic flow, v(2), at midrapidity in Au+Au collisions at √s(NN)=200, 62.4, 39, 27, 19.6, 11.5, and 7.7 GeV, as a function of event-by-event charge ...asymmetry, A(ch), based on data from the STAR experiment at RHIC. We find that π(-) (π(+)) elliptic flow linearly increases (decreases) with charge asymmetry for most centrality bins at √s(NN)=27 GeV and higher. At √s(NN)=200 GeV, the slope of the difference of v(2) between π(-) and π(+) as a function of A(ch) exhibits a centrality dependence, which is qualitatively similar to calculations that incorporate a chiral magnetic wave effect. Similar centrality dependence is also observed at lower energies.
We report high-precision measurements of the longitudinal double-spin asymmetry, ALL, for midrapidity inclusive jet and dijet production in polarized p p collisions at a center-of-mass energy of √ s ...= 200 GeV . The new inclusive jet data are sensitive to the gluon helicity distribution, Δg (x, Q2), for gluon momentum fractions in the range from x ≃ 0.05 to x ≃ 0.5, while the new dijet data provide further constraints on the x dependence of Δ g (x , Q2). The results are in good agreement with previous measurements at √ s = 200 GeV and with recent theoretical evaluations of prior world data. Our new results have better precision and thus strengthen the evidence that Δg(x,Q2) is positive for x > 0.05.
We report new STAR measurements of the single-spin asymmetries AL for W+ and W− bosons produced in polarized proton-proton collisions at s=510 GeV as a function of the decay-positron and ...decay-electron pseudorapidity. The data were obtained in 2013 and correspond to an integrated luminosity of 250 pb−1. The results are combined with previous results obtained with 86 pb−1. A comparison with theoretical expectations based on polarized lepton-nucleon deep-inelastic scattering and prior polarized proton-proton data suggests a difference between the u¯ and d¯ quark helicity distributions for 0.05<x<0.25. In addition, we report new results for the double-spin asymmetries ALL for W±, as well as AL for Z/γ* production and subsequent decay into electron-positron pairs.
One of the primary goals of nuclear physics is to understand the force between nucleons, which is a necessary step for understanding the structure of nuclei and how nuclei interact with each other. ...Rutherford discovered the atomic nucleus in 1911, and the large body of knowledge about the nuclear force that has since been acquired was derived from studies made on nucleons or nuclei. Although antinuclei up to antihelium-4 have been discovered and their masses measured, little is known directly about the nuclear force between antinucleons. Here, we study antiproton pair correlations among data collected by the STAR experiment at the Relativistic Heavy Ion Collider (RHIC), where gold ions are collided with a centre-of-mass energy of 200 gigaelectronvolts per nucleon pair. Antiprotons are abundantly produced in such collisions, thus making it feasible to study details of the antiproton-antiproton interaction. By applying a technique similar to Hanbury Brown and Twiss intensity interferometry, we show that the force between two antiprotons is attractive. In addition, we report two key parameters that characterize the corresponding strong interaction: the scattering length and the effective range of the interaction. Our measured parameters are consistent within errors with the corresponding values for proton-proton interactions. Our results provide direct information on the interaction between two antiprotons, one of the simplest systems of antinucleons, and so are fundamental to understanding the structure of more-complex antinuclei and their properties.
This paper discusses speculative disaster scenarios inspired by hypothetical new fundamental processes that might occur in high-energy relativistic heavy-ion collisions. The authors estimate the ...parameters relevant to black-hole production and find that they are absurdly small. They show that other accelerator and (especially) cosmic-ray environments have already provided far more auspicious opportunities for transition to a new vacuum state, so that existing observations provide stringent bounds. The possibility of producing a dangerous strangelet is discussed in most detail. The authors argue that four separate requirements are necessary for this to occur: existence of large stable strangelets, metastability of intermediate size strangelets, negative charge for strangelets along the stability line, and production of intermediate size strangelets in the heavy ion environment. Both theoretical and experimental reasons why each of these appears unlikely are discussed. In particular, the authors know of no plausible suggestion for why the third or especially the fourth might be true. Given minimal physical assumptions, the continued existence of the Moon, in the form we know it, despite billions of years of cosmic-ray exposure, provides powerful empirical evidence against the possibility of dangerous strangelet production.
We report the first measurements of transverse single-spin asymmetries for inclusive jet and jet+π± production at midrapidity from transversely polarized proton-proton collisions at s=500 GeV. The ...data were collected in 2011 with the STAR detector sampled from 23 pb−1 integrated luminosity with an average beam polarization of 53%. Asymmetries are reported for jets with transverse momenta 6<pT<55 GeV/c and pseudorapidity |η|<1. Presented are measurements of the inclusive-jet azimuthal transverse single-spin asymmetry, sensitive to twist-3 initial-state quark-gluon correlators; the Collins asymmetry, sensitive to quark transversity coupled to the polarized Collins fragmentation function; and the first measurement of the “Collins-like” asymmetry, sensitive to linearly polarized gluons. Within the present statistical precision, inclusive-jet and Collins-like asymmetries are small, with the latter allowing the first experimental constraints on gluon linear polarization in a polarized proton. At higher values of jet transverse momenta, we observe the first nonzero Collins asymmetries in polarized-proton collisions, with a statistical significance of greater than 5σ. The results span a range of x similar to results from semi-inclusive deep-inelastic scattering but at much higher Q2. The Collins results enable tests of universality and factorization breaking in the transverse momentum-dependent formulation of perturbative quantum chromodynamics.
Quark interactions with topological gluon configurations can induce local chirality imbalance and parity violation in quantum chromodynamics, which can lead to the chiral magnetic effect (CME)—an ...electric charge separation along the strong magnetic field in relativistic heavy-ion collisions. The CME-sensitive azimuthal correlator observable ( Δγ) is contaminated by background arising, in part, from resonance decays coupled with elliptic anisotropy (v2) . We report here differential measurements of the correlator as a function of the pair invariant mass (minv) in 20–50% centrality Au + Au collisions at $\sqrt{s_{NN}}$ = 200 GeV by the STAR experiment at the BNL Relativistic Heavy Ion Collider. Strong resonance background contributions to Δγ are observed. At large minv where this background is significantly reduced, the Δγ value is found to be significantly smaller. An event-shape-engineering technique is deployed to determine the v2 background shape as a function of minv . We extract a v2-independent and minv -averaged signal Δγsig = (0.03 ± 0.06 ± 0.08 ) × 10 -4, or (2 ± 4 ± 5)% of the inclusive Δγ(minv > 0.4 GeV/c2) = ( 1.58 ± 0.02 ± 0.02 ) × 10-4, within pion pT = 0.2 –0.8 GeV/c and averaged over pseudorapidity ranges of -1 < η < - 0.05 and 0.05 < η < 1. This represents an upper limit of 0.23 × 10 -4 , or 15% of the inclusive result, at 95% confidence level for the minv -integrated CME contribution.
Here we present high-precision measurements of elliptic, triangular, and quadrangular flow v2, v3, and v4, respectively, at midrapidity for identified hadrons π, p, K, φ, Ks, Λ as a function of ...centrality and transverse momentum in Au+Au collisions at the center-of-mass energy √sNN = 200 GeV. We observe similar vn trends between light and strange mesons which indicates that the heavier strange quarks flow as strongly as the lighter up and down quarks. The number-of-constituent-quark scaling for v2, v3, and v4 is found to hold within statistical uncertainty for 0–10%, 10–40%, and 40–80% collision centrality intervals. The results are compared to several viscous hydrodynamic calculations with varying initial conditions, and could serve as an additional constraint to the development of hydrodynamic models.
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