O presente estudo visa a analisar a percepção e os sentimentos de bem-estar e mal-estar dos professores, sobre o ensino remoto em tempos de pandemia. autores, como Esteve (1999), Nóvoa (2009), Santos ...(2020), Saviani e Galvão (2021), Brooks (2021) e outros, auxiliaram no suporte teórico para entendermos o complexo trabalho da docência. A coleta de dados se deu por meio de questionário on-line pelo google forms para todos os professores da Educação Infantil e Ensino Fundamental do município de Maracaju – MS. Sem sombra de dúvida o professor foi uma das profissões com mais fatores de mal-estar, porém também foi a profissão que mais se reinventou durante a pandemia, superando várias dificuldades, entre elas o de manter o vínculo com os alunos à distância, principalmente quando muitas destas crianças estão em situação de vulnerabilidade.
The use of regional citrate anticoagulation (RCA) in liver failure (LF) patients can lead to citrate accumulation. We aimed to evaluate serum levels of citrate and correlate them with liver function ...markers and with the Cat/Cai in patients under intensive care and undergoing continuous venovenous hemodiafiltration with regional citrate anticoagulation (CVVHDF-RCA). A prospective cohort study in an intensive care unit was conducted. We compared survival, clinical, laboratorial and dialysis data between patients with and without LF. Citrate was measured daily. We evaluated 200 patients, 62 (31%) with LF. Citrate was significantly higher in the LF group. Dialysis dose, filter lifespan, systemic ionized calcium and Cat/Cai were similar between groups. There were weak to moderate positive correlations between Citrate and indicators of liver function and Cat/Cai. The LF group had higher mortality (70.5% vs. 51.8%, p = 0.014). Citrate was an independent risk factor for death, OR 11.3 (95% CI 2.74-46.8). In conclusion, hypercitratemia was an independent risk factor for death in individuals undergoing CVVHDF-ARC. The increase in citrate was limited in the LF group, without clinical significance. The correlation between citrate and liver function indicators was weak to moderate.
Este trabalho tem por objetivo apresentar e discutir sobre as percepções dos professores de Física que atuam na rede estadual de ensino no estado do Paraná, quando tratamos da utilização de materiais ...e instrumentos metodológicos utilizados no ensino de alunos com deficiência visual. Possuímos como questionamento fenomenológico: O que é isso: o ensino de Física para alunos com deficiência visual por meio de instrumentos, ferramentas e materiais pelas perspectivas e experiências dos docentes? Esperamos por meio dessa investigação e análise contribuir com a inclusão de alunos com deficiência visual no ambiente escolar e com a elaboração de novos materiais necessário para o ensino de Física inclusivo e de qualidade. A análise do corpus identificou três categorias finais emergentes, são essas: i. Possibilidades para a promoção do ensino de Física para alunos com deficiência visual; ii. Não utilizo instrumentos metodológicos para ensinar e não sei exatamente o que utilizar e iii. Tenho pouco conhecimento sobre instrumentos para o ensino de alunos com deficiência visual. Verificamos que os docentes destacam como possibilidades para o ensino de Física para alunos com deficiência visual os materiais táteis e os estímulos sensoriais, os recursos de tecnologia assistivas e os leitores de tela.
The growing technological advance in agriculture, verified through the introduction of machines, fertilizers, new cultivars, and expansion of agricultural frontiers, has provided, in general, an ...increase in the average yield of crops due to the rational management of the soil-climate-plant system. However, as the soil is managed without adopting conservationist practices, imbalances and instability occur, constituting serious problems such as desertification, salinization, soil erosion, etc. Thus, this study aimed to determine the soil loss tolerance by erosion in the western mesoregion of Maranhão. The methods used to determine tolerance used effective depth (h), textural ratio (r), textural ratio and clay content in the A horizon, organic matter, and permeability, where the equations for each method were: T= h. r. 1000-1 (Method I); T = h. ra. 1000-1 (Method II) and T = h. ra. m. P. 1000-1 (Method III). The highest soil loss tolerance values were identified in method I (1.95 t ha-1 yr-1), then method III (0.76 t ha-1 yr-1), and finally, method II (0.67 t ha-1 yr-1), observing soil loss tolerance values differed about the method used.
The role of apoptosis‐associated speck‐like protein containing a caspase‐1 recruitment domain (ASC) in bone healing remains to be understood. To address this issue, we investigated the requirement of ...inflammasome‐related genes in response to bone morphogenetic protein 7 (BMP7)‐induced osteoblast differentiation in vitro. To validate the importance of ASC on osteogenesis, we subjected wild‐type (WT) and ASC knockout C57BL/6 mice (ASC KO) to tibia defect to evaluate the bone healing process (up to 28 days). Our in vitro data showed that there is an involvement of ASC during BMP7‐induced osteoblast differentiation, concomitant to osteogenic biomarker expression. Indeed, primary osteogenic cells from ASC KO presented a lower osteogenic profile than those obtained from WT mice. To validate this hypothesis, we evaluated the bone healing process of tibia defects on both WT and ASC KO mice genotypes and the ASC KO mice were not able to fully heal tibia defects up to 28 days, whereas WT tibia defects presented a higher bone de novo volume at this stage, evidencing ASC as an important molecule during osteogenic phenotype. In addition, we have shown a higher involvement of runt‐related transcription factor 2 in WT sections during bone repair, as well as circulating bone alkaline phosphatase isoform when both were compared with ASC KO mice behavior. Altogether, our results showed for the first time the involvement of inflammasome during osteoblast differentiation and osteogenesis, which opens new avenues to understand the pathways involved in bone healing.
ASC contributes to osteoblast differentiation and bone de novo deposition, opening new avenues to understand the complex mechanism coupling inflammation landscape and osteoblastogenesis during bone healing.
Childhood overweight and obesity are a global concern, with prevalence rising dramatically over the last decades. The condition is caused by an increase in energy intake and reduction of physical ...activity, leading to excessive fat accumulation, followed by systemic chronic inflammation and altered function of immune cell responses. This study aimed at providing new insights regarding sex-specificity on the inflammatory response to obesity in the young patient.
Forty-three Brazilian obese adolescents (Female = 22 and Male=21, BMI (body mass index) Z-score average = 2.78 ± 0.51) and forty-nine eutrophic adolescents (Female = 24 and Male = 25, BMI Z-score average = -0.35 ± 0.88) were enrolled in the study. Anthropometrical analyses and blood cell counts were carried out. Using Luminex®xMAP™ technology, circulating serum cytokines, chemokines, and inflammatory biomarkers were analyzed. Two-way ANOVA test, Tukey's test, and Spearman's correlation coefficient were employed, with a significance threshold set at p < 0.05.
We identified increased levels of serum amyloid A (SAA), platelets, and leukocytes solely in male obese patients. We found a noteworthy sex-dependent pattern in regard to inflammatory response: obese boys showed higher TNFβ, IL15, and IL2 and lower IL10 and IL13, while obese girls showed increased TNFα, CCL3, CCL4, and IP10 content in the circulation. BMI Z-score was significantly linearly correlated with neutrophils, leukocytes, platelets, SAA, TNFα, CCL3, CCL4, IP10, and IL13 levels within the entire cohort (non-sex-dependent).
Our data support a complex relationship between adiposity, blood cell count, and circulating inflammatory cytokine content. High SAA levels suggest that this factor may play a critical role in local and systemic inflammation. In the eutrophic group, females presented a lower status of inflammation, as compared to males. Both obese boys and girls showed an increased inflammatory response in relation to eutrophic counterparts. Taken together, results point out to clear sex dimorphism in the inflammatory profile of obese adolescents.
O presente trabalho pretende mapear a institucionalização da sociologia do direito nas faculdades de direito indicadas pelo selo OAB Recomenda. Para tanto, foram analisados os dados obtidos a partir ...de busca nos sites das instituições de ensino objeto do presente estudo, bem como das informações enviadas por e-mail pela secretaria, a respeito do formato e do ensino da sociologia do direito ou da sociologia jurídica (neste estudo utilizadas como sinônimos). Por isso, buscou-se alguns dados específicos sobre essa disciplina nos currículos das instituições pesquisadas, em especial se há na estrutura curricular uma disciplina voltada ao seu ensino; qual a nomenclatura atribuída a ela; se a sua ementa deixa claro qual é o seu objeto e, por fim; se a bibliografia adotada abrange textos e livros próprios de sociologia jurídica ou de sociologia do direito, ou se indicam apenas livros e textos de outros campos do saber. Tal mapeamento mostra-se relevante na medida em que a legislação que rege o ensino jurídico atualmente privilegia a interdisciplinaridade dos saberes, sendo este o lugar da sociologia jurídica nos cursos de direito.
We studied the relationship between body morphometric traits, and their underlying association with milk production (MP), lactation length (LL), first calving interval (FCI) and subsequent calving ...interval (CI) of crossbred progeny of Murrah × Jafarabadi buffalo aiming to assist in selection programs. We carried out principal component analysis (PCA) of the body morphometric traits, which include breast width (BW), thigh width (THW), hip width (HW), rump width (RW), rump length (RL), body depth (BD), body length (BL), height withers (HEW), rear height (RH), shoulder width (SW), thorax width (TW), loin width (LW), distance from the head to ischium (DHI), and thoracic perimeter (TP). We determined the association of morphometric traits with milk/reproduction traits using canonical correlation analysis (CCA). The analysis revealed that the first six PCA accounted for 82.14% of the total observed variation, and the traits THW, HW, TW, LW, RW, HEW, TP, RH, and BW, accounted for almost half (48.00%) of the total variance indicating a higher contribution in body structural conformation. The first canonical function was significant (p<0.05), accounted for 72.46% of the total variance, and the canonical correlation was 0.56, indicating the dependence between both groups of traits. Higher canonical loadings were obtained for LL (0.49), FCI (0.46), BW (-0.71), BL (-0.56), DHI (-0.34), HEW, (-0.38) and TP (-0.50). These traits were most important for the derivation of canonical statistical variables, and presented a higher canonical correlations (r) between the dependent (LL/FCI) and independent (BW, BL, DHI, HEW and TP) groups. The results could suggest that the body morphometric traits THW, HW, TW, LW, RW, HEW, BD, TP, RH, and BW could play important role in body structural composition, indicating a suitable functional type, and aid designing of selection programs for buffalo breeding.
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