We report on a cystinuric patient in whom unilateral hydronephrosis developed as a result of massive renal stone formation owing to non-compliance of systemic penicillamine therapy. At operation a ...large number of calculi could not be removed for technical reasons. After successful in vitro dissolution of 1 calculus using a 0.5 per cent solution of D-penicillamine at pH 8.0 the same solution was used to irrigate the renal collecting system via a nephrostomy tube. After 2 months of daily irrigations, which were decreased to 2 times a week for another 2 months, all the stones appeared radiographically to have disappeared. At followup 2 years after removal of the nephrostomy tube the patient is on regular systemic therapy with no evidence of residual or recurrent stone formation.
A procedure is described for determining the initial value of a single or multiple input signature register (used to compress responses in built-in testing) so that the final good-machine signature ...is always constant, e.g. all zeros. In this way, it is possible to determine if a fault has been detected by ORing the outputs of the register stages. Since the OR operation can be built-in, a single observation of the output of the OR gate will determine if the circuit has passed the test.< >
A method is presented of operating on signatures from a cycling register such that the complexity of identifying multiple failing tests is comparable to that of identifying a single failing test. The ...method has some interesting aliasing characteristics. The authors show the probability of aliasing and suggest how it can be kept relatively small. The efficiency of the method decreases as the number of failing tests increase. The reduction in efficiency is due to an increase in aliasing probability caused by footprints being lost in the cycling registers. The larger the number of failing tests, the greater is the chance that aliasing will occur.< >
A single an-encephalus neonate kidney graft was transplanted into the portal system of a 6-year-old recipient who had previously undergone removal of the right kidney and inferior vena cava because ...of Wilms tumor. The left kidney ceased to function shortly thereafter. The child was supported very poorly on hemodialysis, and showed repeated very high levels of cytotoxic antibodies in her serum. The first cross-negative kidney graft that was available harbored two main arteries and duplicate collecting system with two very thin ureters. These vascular anatomic and pathologic variations of both donor graft and recipient necessitated the use of the portal system for renal graft venous drainage and the aorta for the graft revascularization. The ureters that had pinpoint-like lumen were inserted together into the lumen of the native ureter stump and fixated. One year after the transplantation the serum creatinine level is 1.8 mg/dL.
Tumor-like proliferative lesions were discovered on cystourethrography and cystoscopy in two children, one with severe bacterial urinary tract infection and the other with painless terminal ...hematuria. Histologically, these lesions were characterized by inflammatory infiltration and proliferative changes of the bladder epithelium. Appropriate treatment, including antibiotics, resulted in complete disappearance of the bladder lesions in both patients. The development of such lesions is related to the potential for nonneoplastic proliferation and metaplasia of the bladder epithelium and is considered to be the result of irritation associated with infection or other chemical and physical factors. The known malignant potential of such bladder pathology indicates a need for careful, long-term follow-up in such patients, including children.
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