This study aims to reveal the bibliometric characteristics of publications on educational research from diverse perspectives, including the level of national-international collaborations, the ...percentage change in open-access papers, and interactions with other disciplines. Through bibliometric analysis, the data were collected from Web of Science (WoS), “Education and Educational Research (E&ER),”“Psychology, Educational (PE),”“Education, Special (ES)” and “Education Scientific Disciplines (ESD)” categories, during 2011 to 2020. The findings suggest that the number of publications in each category and the percentage of open-access publications have increased regularly. However, it was observed that categories, especially the ES category, were partially falling behind, as compared to the growth in WoS; while the ES and the PE categories were the highest regarding national-international collaborations over time. Both collaboration levels were the highest in the E&ER category. It was concluded that the multi-authorship trend has rapidly increased, the number of references has regularly increased, and specifically, the PE category has been distinguished from others in terms of the references used. Meanwhile, the change over time in the aggregate impact factor, calculated for each category as a measure of the widespread impact of the studies, pointed to inflation. The results show that educational research is becoming more organized and international, while less fragmented. Moreover, the findings support that educational research is interdisciplinary in essence and diverse in content.
In this paper, semisimple semigroups, duo semigroups, right (left) zero semigroups, right (left) simple semigroups, semilattice of left (right) simple semigroups, semilattice of left (right) groups ...and semilattice of groups are characterized in terms of soft intersection semigroups, soft intersection ideals of semigroups. Moreover, soft normal semigroups are defined and some characterizations of semigroups with soft normality are given.
Soft covered ideals in semigroups Özlü, Şerif; Sezgin, Aslıhan
Acta universitatis sapientiae. Mathematica,
11/2020, Volume:
12, Issue:
2
Journal Article
Peer reviewed
Open access
In this work, soft covered ideals in semigroups are constructed and in this concept, soft covered semigroups, soft covered left (right) ideals, soft covered interior ideals, soft covered ...(generalized) bi-ideals and soft covered quasi ideals of a semigroup are defined. Various properties of these ideals are introduced and the interrelations of these soft covered ideals and the relations of soft anti covered ideals and soft covered ideals are investigated.
In this paper, by defining soft intersection–union product, we make a new approach to the classical ring theory via soft set theory, with the concept of soft union rings, ideals and bi-ideals. ...Moreover, we characterize regular, regular duo, intra-regular and strongly regular rings by soft union rings and ideals.
Objective: Relapsed and refractory CD19-positive B-cell acute
lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL)
are the focus of studies on hematological cancers. Treatment of
these ...malignancies has undergone recent transformation with the
development of new gene therapy and molecular biology techniques,
which are safer and well-tolerated therapeutic approaches. The CD19
antigen is the most studied therapeutic target in these hematological
cancers. This study reports the results of clinical-grade production,
quality control, and in vivo efficacy processes of ISIKOK-19 cells as the
first academic clinical trial of CAR-T cells targeting CD19-expressing B
cells in relapsed/refractory ALL and NHL patients in Turkey.
Materials and Methods: We used a lentiviral vector encoding the
CD19 antigen-specific antibody head (FMC63) conjugated with the
CD8-CD28-CD3ζ sequence as a chimeric antigen receptor (CAR) along
with a truncated form of EGFR (EGFRt) on human T-lymphocytes
(CAR-T). We preclinically assessed the efficacy and safety of the
manufactured CAR-T cells, namely ISIKOK-19, from both healthy
donors’ and ALL/NHL patients’ peripheral blood mononuclear cells.
Results: We showed significant enhancement of CAR lentivirus
transduction efficacy in T-cells using BX-795, an inhibitor of the
signaling molecule TBK1/IKKƐ, in order to cut the cost of CAR-T cell
production. In addition, ISIKOK-19 cells demonstrated a significantly
high level of cytotoxicity specifically against a CD19+ B-lymphocyte
cancer model, RAJI cells, in NOD/SCID mice.
Conclusion: This is the first report of preclinical assessment of
efficacy and safety analysis of CAR-T cells (ISIKOK-19) targeting
CD19-expressing B cells in relapsed/refractory ALL and NHL patients
in Turkey.
ObjectiveChimeric antigen receptor T (CAR-T) cell therapies have already made an impact on the treatment of B-cell malignancies. Although CAR-T cell therapies are promising, there are concerns about ...commercial products regarding their affordability and sustainability. In this preliminary study, the results of the first production and clinical data of an academic CAR-T cell (ISIKOK-19) trial in Turkey are presented. Materials and MethodsA pilot clinical trial (NCT04206943) designed to assess the safety and feasibility of ISIKOK-19 T-cell therapy for patients with relapsed and refractory CD19+ tumors was conducted and participating patients received ISIKOK-19 infusions between October 2019 and July 2021. The production data of the first 8 patients and the clinical outcome of 7 patients who received ISIKOK-19 cell infusions are presented in this study. ResultsNine patients were enrolled in the trial 5 with acute lymphoblastic leukemia (ALL) and 4 with non-Hodgkin lymphoma (NHL), but only 7 patients could receive treatment. Two of the 3 participating ALL patients and 3 of the 4 NHL patients had complete/partial response (overall response rate: 72%). Four patients (57%) had CAR-T-related toxicities (cytokine release syndrome, CAR-T-related encephalopathy syndrome, and pancytopenia). Two patients were unresponsive and had progressive disease following CAR-T therapy. Two patients with partial response had progressive disease during follow-up. ConclusionProduction efficacy and fulfillment of the criteria of quality control were satisfactory for academic production. Response rates and toxicity profiles were also acceptable for this heavily pretreated/refractory patient group. ISIKOK-19 cells appear to be a safe, economical, and efficient treatment option for CD19+ tumors. However, the findings of this study need to be supported by the currently ongoing ISIKOK-19 clinical trial.
Semigroups are the building blocks of algebra as they have application in automata, coding the-ory, formal languages, and theoretical computer science. They are also used in the solutions of graph ...theory and optimization theory. For the advanced study of algebraic structures and their applications, ideals are essential. The generalization of ideals in algebraic structures is necessary for further research on algebraic structures. The main purpose of this paper is to present the notion of soft intersection almost subsemigroup of a semigroup, which is a generalization of soft intersection subsemigroup and investigate its basic pro-perties in detail. In this context, we also obtain many striking relationships between almost subsemigroups and soft intersection almost subsemigroups concerning minimality, primeness, semiprimeness and strongly primeness.
On operations of soft sets Sezgin, Aslıhan; Atagün, Akın Osman
Computers & mathematics with applications (1987),
03/2011, Volume:
61, Issue:
5
Journal Article
Peer reviewed
Open access
Soft set theory, proposed by Molodtsov, has been regarded as an effective mathematical tool to deal with uncertainties. In this paper, first we prove that certain De Morgan’s law hold in soft set ...theory with respect to different operations on soft sets. Then, we discuss the basic properties of operations on soft sets such as intersection, extended intersection, restricted union and restricted difference. Moreover, we illustrate their interconnections between each other. Also we define the notion of restricted symmetric difference of soft sets and investigate its properties. The main purpose of this paper is to extend the theoretical aspect of operations on soft sets.
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