The elaboration of previously reported indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis, in vitro inhibitory values for IMPDH II, PBMC ...proliferation and physicochemical properties are discussed.
The elaboration of previously reported indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis, in vitro inhibitory values for IMPDH II, PBMC proliferation and physicochemical properties are discussed.
The study of non-oxazole containing indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis and in vitro inhibitory values for IMPDH II are ...discussed.
The study of non-oxazole containing indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis and in vitro inhibitory values for IMPDH II are discussed.
The Arabidopsis thaliana CONSTANS (CO) gene which promotes flowering in long days was recently isolated by chromosome walking. The mapping of QTLs controlling flowering time in Brassica species has ...identified genomic regions that contain homologues of the CO gene. Four genes homologous to the Arabidopsis CO gene were isolated from a pair of homoeologous loci in each of two doubled-haploid Brassica napus lines displaying different flowering times, N-o-1 and N-o-9. The four genes, BnCOa1, BnCOa9, BnCOb1 and BnCOb9, are located on linkage groups N10 and N19, and are highly similar to each other and to the Arabidopsis CO gene. Two regions of the proteins are particularly well conserved, a N-terminal region with two putative zinc fingers and a C-terminal region which may contain a nuclear localization signal. All four genes appear to be expressed in B. napus. The BnCOa1 allele was shown to complement the co-2 mutation in Arabidopsis in a dosage-dependent manner causing earlier flowering than in wild type under both long- and short-day conditions.
The syntheses and pharmacological profiles of some 2-trifluoromethyl-8-methoxyquinoline-5-carboxamides are described.
SCH351591 is a potent selective inhibitor of phosphodiesterase type 4 (PDE4).
The ...syntheses and pharmacological profiles of some 2-trifluoromethyl-8-methoxyquinoline-5-carboxamides are described.
SCH351591 is a potent selective inhibitor of PDE4.
Efficient gas-phase VUV frequency up-conversion Merriam, A.J.; Sharpe, S.J.; Hui Xia ...
IEEE journal of selected topics in quantum electronics,
11/1999, Volume:
5, Issue:
6
Journal Article
Peer reviewed
We describe a pulsed, atomic lead (Pb) vapor-based vacuum ultraviolet (VUV) frequency converter from 233 to 186 nm with near-unity photon conversion efficiency. This conversion is attained without ...phasematching and is accomplished by using electromagnetically induced transparency to drive a Raman transition to near-maximal coherence without loss or beam blow-up. Under these conditions, the linear and nonlinear polarizations of the generated 186-nm field are of the same order and complete conversion from the 233-nm field occurs within a single (nonphasematched) coherence length.
ATRX is an X-encoded member of the SNF2 family of ATPase/helicase proteins thought to regulate gene expression by modifying chromatin at target loci. Mutations in ATRX provided the first example of a ...human genetic disease associated with defects in such proteins. To better understand the role of ATRX in development and the associated abnormalities in the ATR-X (alpha thalassemia mental retardation, X-linked) syndrome, we conditionally inactivated the homolog in mice, Atrx, at the 8- to 16-cell stage of development. The protein, Atrx, was ubiquitously expressed, and male embryos null for Atrx implanted and gastrulated normally but did not survive beyond 9.5 days postcoitus due to a defect in formation of the extraembryonic trophoblast, one of the first terminally differentiated lineages in the developing embryo. Carrier female mice that inherit a maternal null allele should be affected, since the paternal X chromosome is normally inactivated in extraembryonic tissues. Surprisingly, however, some carrier females established a normal placenta and appeared to escape the usual pattern of imprinted X-inactivation in these tissues. Together these findings demonstrate an unexpected, specific, and essential role for Atrx in the development of the murine trophoblast and present an example of escape from imprinted X chromosome inactivation.
A programme designed to develop the capacity of voluntary agencies and community groups to deliver information, advice and guidance (IAG) on learning and work to their clients and members is ...outlined. Four forms of capacity building are distinguished: internal IAG capacity building, based on developing IAG resources within the agency or group itself; external IAG capacity building, based on the agency or group offering IAG resources delivered by outside providers; learning capacity building, based on learning brokerage; and organisational capacity building, contributing to the development of the agency or group in broader terms.
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