Aims. We evaluate non-local thermodynamical equilibrium (non-LTE) line formation for the two ions of iron and check the ionization equilibrium between Fe i and Fe ii in model atmospheres of the cool ...reference stars based on the best available complete model atom for neutral and singly-ionized iron. Methods. We present a comprehensive model atom for Fe with more than 3000 measured and predicted energy levels. As a test and first application of the improved model atom, iron abundances are determined for the Sun and five stars with well determined stellar parameters and high-quality observed spectra. The efficiency of inelastic collisions with hydrogen atoms in the statistical equilibrium of iron is empirically estimated from inspection of their different influence on the Fe i and Fe ii lines in the selected stars. Results. Non-LTE leads to systematically depleted total absorption in the Fe i lines and to positive abundance corrections in agreement with the previous studies, however, the magnitude of such corrections is smaller compared to the earlier results. These non-LTE corrections do not exceed 0.1 dex for the solar metallicity and mildly metal-deficient stars, and they vary within 0.21 dex and 0.35 dex in the very metal-poor stars HD 84937 and HD 122563, respectively, depending on the assumed efficiency of collisions with hydrogen atoms. Based on the analysis of the Fe i/Fe ii ionization equilibrium in these two stars, we recommend to apply the Drawin formalism in non-LTE studies of Fe with a scaling factor of 0.1. For the Fe ii lines non-LTE corrections do not exceed 0.01 dex in absolute value over the whole range of stellar parameters that are considered. This study reveals two problems. The first one is that gf-values available for the Fe i and Fe ii lines are not accurate enough to pursue high-accuracy absolute stellar abundance determinations. For the Sun, the mean non-LTE abundance obtained from 54 Fe i lines is 7.56 ± 0.09 and the mean abundance from 18 Fe ii lines varies between 7.41 ± 0.11 and 7.56 ± 0.05 depending on the source of the gf-values. The second problem is that lines of Fe i give, on average, a 0.1 dex lower abundance compared with those of Fe ii lines for HD 61421 and HD 102870, even when applying a differential line-by-line analysis with regard to the Sun. A disparity between neutral atoms and first ions points to problems of stellar atmosphere modelling or/and effective temperature determination.
Variant selection of α (hexagonal close-packed, hcp) phase during its precipitation from β (body-centered cubic, bcc) matrix plays a key role in determining the microstructural state and mechanical ...properties of α/β titanium alloys. In this work, we develop a three-dimensional quantitative phase field model to predict variant selection and microstructural evolution during β→α transformation in Ti–6Al–4V (wt.%) under the influence of both external and internal stresses. The model links its inputs directly to thermodynamic and mobility databases, and incorporates the crystallography of bcc to hcp transformation, elastic anisotropy and defects within semi-coherent α/β interfaces in its total free energy formulation. It is found that, for a given undercooling, the development of a transformation texture (also called microtexture) of the α phase due to variant selection during precipitation is determined by the interplay between externally applied stress or strain and internal stress generated by the precipitation reaction itself. For example, the growth of pre-existing α precipitates is accompanied by selective nucleation and growth of secondary α plates of certain variants that may not be the ones preferred by the initially applied stress. Possible measures to reduce transformation texture are discussed.
A general approach is proposed to predict the equilibrium shapes of precipitates in crystalline solids as function of size and coherency state. The model incorporates effects of interfacial defects ...such as misfit dislocations and structural ledges on transformation strain and on interfacial energy. Using α precipitation in α/β titanium alloys as an example, various possible equilibrium shapes of precipitates having different defect contents at interfaces are obtained by phase-field simulations. The simulation results agree with experimental observations in terms of both precipitate habit plane orientation and defect content at the interface. In combination with crystallographic theories of interfaces and experimental characterization of habit plane of finite precipitates, this approach has the ability to predict the coherency state (i.e. defect structures at interfaces) and equilibrium shape of finite precipitates.
The timing of early human dispersal to Asia is a central issue in the study of human evolution. Excavations in predominantly lacustrine sediments at Majuangou, Nihewan basin, north China, uncovered ...four layers of indisputable hominin stone tools. Here we report magnetostratigraphic results that constrain the age of the four artefact layers to an interval of nearly 340,000 yr between the Olduvai subchron and the Cobb Mountain event. The lowest layer, about 1.66 million years old (Myr), provides the oldest record of stone-tool processing of animal tissues in east Asia. The highest layer, at about 1.32 Myr, correlates with the stone tool layer at Xiaochangliang, previously considered the oldest archaeological site in this region. The findings at Majuangou indicate that the oldest known human presence in northeast Asia at 40° N is only slightly younger than that in western Asia. This result implies that a long yet rapid migration from Africa, possibly initiated during a phase of warm climate, enabled early human populations to inhabit northern latitudes of east Asia over a prolonged period.
The goal of this study was to determine the effects of genetic variation in the organic cation transporter 1, OCT1, on the pharmacokinetics of the antidiabetic drug, metformin. Twenty healthy ...volunteers with known OCT1 genotype agreed to participate in the study. Each subject received two oral doses of metformin followed by collection of blood and urine samples. OCT1 genotypes had a significant (P<0.05) effect on metformin pharmacokinetics, with a higher area under the plasma concentration–time curve (AUC), higher maximal plasma concentration (Cmax), and lower oral volume of distribution (V/F) in the individuals carrying a reduced function OCT1 allele (R61C, G401S, 420del, or G465R). The effect of OCT1 on metformin pharmacokinetics in mice was less than in humans possibly reflecting species differences in hepatic expression level of the transporter. Our studies suggest that OCT1 genotype is a determinant of metformin pharmacokinetics.
Clinical Pharmacology & Therapeutics (2008) doi:10.1038/sj.clpt.6100275
We present atmospheric parameters for 51 nearby F and G dwarf and subgiant stars uniformly distributed over the -2.60 < Fe/H < +0.20 metallicity range that is suitable for the Galactic chemical ...evolution research. Lines of iron in the two ionization stages, Fe sub(I) and Fe sub(II), were used to derive a homogeneous set of effective temperatures, surface gravities, iron abundances, and microturbulence velocities. Our spectroscopic analyses took advantage of employing high-resolution (R > or =, slanted 60,000) Shane/Hamilton and Canada-France-Hawaii Telescope/ESPaDOnS observed spectra and non-LTE (NLTE) line formation for Fe sub(I) and Fe sub(II) in the classical one-dimensional model atmospheres. The spectroscopic method was tested in advance with the 20 benchmark stars, for which there are multiple measurements of the infrared flux method effective temperature and their Hipparcos parallax error is less than 10%. We found NLTE abundances from lines of Fe sub(I) and Fe sub(II) to be consistent within 0.06 dex for every benchmark star, when applying a scaling factor of S sub(H) = 0.5 to the Drawinian rates of inelastic Fe+H collisions. The obtained atmospheric parameters were checked for each program star by comparing its position in the log g-T sub(eff) plane with the theoretical evolutionary track of given metallicity and alpha -enhancement in the Yi et al. grid. Our final effective temperatures lie exactly in between the T sub(IRFM) scales of Alonso et al., and Casagrande et al., with a mean difference of +46 and -51 K, respectively. NLTE leads to higher surface gravity compared with that for LTE. The shift in log g is smaller than 0.1 dex for stars with Fe/H > or =, slanted -0.75, T sub(eff) < or =, slant 5750 K, or log g > or =, slanted 4.20. NLTE analysis is crucial for the very metal-poor turnoff and subgiant stars, for which the shift in log g between NLTE and LTE can be up to 0.5 dex. The obtained accurate atmospheric parameters will be used in the forthcoming papers to determine NLTE abundances of important astrophysical elements from lithium to europium and to improve observational constraints on the chemodynamical models of the Galaxy evolution.
The global distribution patterns of 14918 geo-referenced occurrences from 394 living brachiopod species were mapped in 5° grid cells, which enabled the visualization and delineation of distinct ...bioregions and biodiversity hotspots. Further investigation using cluster and network analyses allowed us to propose the first systematically and quantitatively recognized global bioregionalization framework for living brachiopods, consisting of five bioregions and thirteen bioprovinces. No single environmental or ecological variable is accountable for the newly proposed global bioregionalization patterns of living brachiopods. Instead, the combined effects of large-scale ocean gyres, climatic zonation as well as some geohistorical factors (e.g., formation of land bridges and geological recent closure of ancient seaways) are considered as the main drivers at the global scale. At the regional scale, however, the faunal composition, diversity and biogeographical differentiation appear to be mainly controlled by seawater temperature variation, regional ocean currents and coastal upwelling systems.
As a major component of the LAMOST Galactic surveys, the LAMOST Spectroscopic Survey of the Galactic Anticentre (LSS-GAC) aims to survey a significant volume of the Galactic thin/thick discs and halo ...for a contiguous sky area of over 3400 deg2 centred on the Galactic anticentre (|b| ≤ 30°, 150 ≤ l ≤ 210°), and obtain λλ3700–9000 low-resolution (R ∼ 1800) spectra for a statistically complete sample of ∼3 M stars of all colours down to a limiting magnitude of r ∼ 17.8 mag (to 18.5 mag for limited fields). Together with Gaia, the LSS-GAC will yield a unique data set to advance our understanding of the structure and assemblage history of the Galaxy, in particular its disc(s). In addition to the main survey, the LSS-GAC will also target hundreds of thousands objects in the vicinity fields of M 31 and M 33 and survey a significant fraction (over a million) of randomly selected very bright stars (r ≤ 14 mag) in the Northern hemisphere. During the Pilot and the first year Regular Surveys of LAMOST, a total of 1042 586 750 867 spectra of a signal-to-noise ratio S/N(7450 Å) ≥ 10 S/N(4650 Å) ≥ 10 have been collected. In this paper, we present a detailed description of the target selection algorithm, survey design, observations and the first data release of value-added catalogues (including radial velocities, effective temperatures, surface gravities, metallicities, values of interstellar extinction, distances, proper motions and orbital parameters) of the LSS-GAC.
Summary
Deficiency of CARD9 (caspase recruitment domain‐containing protein 9) has been reported in individuals with recurrent and invasive fungal infections. We report on a patient who first had ...Trichosporon asahii affecting the skin then Candida albicans infections involving the digestive tract and knee joint, along with elevated serum IgE. After stimulation with C. albicans, peripheral blood mononuclear cells of this patient produced less tumour necrosis factor‐α, interferon‐γ and interleukin‐17 than those of healthy controls. Furthermore, the serum IgE levels of this patient were positively correlated with the severity of fungal infection during the course of treatment. Sanger sequencing identified one homozygous frameshift mutation (p.D274fsX60) in CARD9. We further performed a review including 48 cases with CARD9 deficiency. According to the data published previously, CARD9‐deficient patients demonstrated obviously elevated IgE in serum (median 1300 IU mL−1), which could distinguish them from otherwise healthy people with fungal infections (area under the curve 0·94, P < 0·001). Patients carrying the mutations Q289X and Q295X had a higher mortality rate (24% vs. 0%, P < 0·05). Patients with the mutations R18W, R35Q, R70W, G72S or Y91H in the CARD domain, and the nonsense mutation Q295X in the coiled‐coil domain, seemed to be more prone to Candida infections (90% vs. 20%, P < 0·005) and central nervous system infections (60% vs. 12%, P < 0·005).
What's already known about this topic?
CARD9 deficiency is a rare autosomal recessive genetic defect in T helper 17 immunity, resulting in susceptibility to recurrent and invasive fungal infections.
Patients with genetic defects in T helper 17 immunity are prone to hyper‐IgE syndrome.
What does this study add?
We report a patient with CARD9 p.D274fsX60 mutation manifested as multiple organs infections by Trichosporon asahii and Candida albicans.
This study enriches the phenotypic spectrum of CARD9 deficiency.
IgE level seems to be a possible clue for diagnosis or therapeutic effect of fungal infection in CARD9‐deficient patients.
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