An ultrahigh performance MoS2 photodetector with high photoresponsivity (1.94 × 106 A W–1) and detectivity (1.29 × 1012 Jones) under 520 nm and 4.63 pW laser exposure is demonstrated. This ...photodetector is based on a methyl‐ammonium lead halide perovskite/MoS2 hybrid structure with (3‐aminopropyl)triethoxysilane doping. The performance degradation caused by moisture is also minimized down to 20% by adopting a new encapsulation bilayer of octadecyltrichlorosilane/polymethyl methacrylate.
Patterned graphene sheets are fabricated by an inkjet printing technique. High line resolution and sustained electrical conductivity is achieved, and tuning of the sheet resistance is dependent on ...the concentration of graphene oxide ink and the number of print layers. A patterned graphene‐based thin film is also applied as a practical wideband dipole antenna.
Use of intravascular ultrasound (IVUS) promotes better clinical outcomes for coronary intervention in complex coronary lesions. However, randomized data demonstrating the clinical usefulness of IVUS ...are limited for lesions treated with drug-eluting stents.
To determine whether the long-term clinical outcomes with IVUS-guided drug-eluting stent implantation are superior to those with angiography-guided implantation in patients with long coronary lesions.
The Impact of Intravascular Ultrasound Guidance on Outcomes of Xience Prime Stents in Long Lesions (IVUS-XPL) randomized, multicenter trial was conducted in 1400 patients with long coronary lesions (implanted stent ≥28 mm in length) between October 2010 and July 2014 at 20 centers in Korea.
Patients were randomly assigned to receive IVUS-guided (n = 700) or angiography-guided (n = 700) everolimus-eluting stent implantation.
Primary outcome measure was the composite of major adverse cardiac events, including cardiac death, target lesion-related myocardial infarction, or ischemia-driven target lesion revascularization at 1 year, analyzed by intention-to-treat.
One-year follow-up was complete in 1323 patients (94.5%). Major adverse cardiac events at 1 year occurred in 19 patients (2.9%) undergoing IVUS-guided and in 39 patients (5.8%) undergoing angiography-guided stent implantation (absolute difference, -2.97% 95% CI, -5.14% to -0.79%) (hazard ratio HR, 0.48 95% CI, 0.28 to 0.83, P = .007). The difference was driven by a lower risk of ischemia-driven target lesion revascularization in patients undergoing IVUS-guided (17 2.5%) compared with angiography-guided (33 5.0%) stent implantation (HR, 0.51 95% CI, 0.28 to 0.91, P = .02). Cardiac death and target lesion-related myocardial infarction were not significantly different between the 2 groups. For cardiac death, there were 3 patients (0.4%) in the IVUS-guided group and 5 patients (0.7%) in the angiography-guided group (HR, 0.60 95% CI, 0.14 to 2.52, P = .48). Target lesion-related myocardial infarction occurred in 1 patient (0.1%) in the angiography-guided stent implantation group (P = .32).
Among patients requiring long coronary stent implantation, the use of IVUS-guided everolimus-eluting stent implantation, compared with angiography-guided stent implantation, resulted in a significantly lower rate of the composite of major adverse cardiac events at 1 year. These differences were primarily due to lower risk of target lesion revascularization.
clinicaltrials.gov Identifier: NCT01308281.
Osteoarthritis (OA), primarily characterized by cartilage degeneration, is caused by an imbalance between anabolic and catabolic factors. Here, we investigated the role of zinc (Zn2+) homeostasis, ...Zn2+ transporters, and Zn2+-dependent transcription factors in OA pathogenesis. Among Zn2+ transporters, the Zn2+ importer ZIP8 was specifically upregulated in OA cartilage of humans and mice, resulting in increased levels of intracellular Zn2+ in chondrocytes. ZIP8-mediated Zn2+ influx upregulated the expression of matrix-degrading enzymes (MMP3, MMP9, MMP12, MMP13, and ADAMTS5) in chondrocytes. Ectopic expression of ZIP8 in mouse cartilage tissue caused OA cartilage destruction, whereas Zip8 knockout suppressed surgically induced OA pathogenesis, with concomitant modulation of Zn2+ influx and matrix-degrading enzymes. Furthermore, MTF1 was identified as an essential transcription factor in mediating Zn2+/ZIP8-induced catabolic factor expression, and genetic modulation of Mtf1 in mice altered OA pathogenesis. We propose that the zinc-ZIP8-MTF1 axis is an essential catabolic regulator of OA pathogenesis.
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•Zinc importer ZIP8 is upregulated in osteoarthritic cartilage of human and mice•ZIP8-mediated zinc influx activates MTF1 transcription factor•Genetic modulation of Zip8 and Mtf1 in mice alters OA pathogenesis•Zinc·ZIP8·MTF1 axis regulates catabolic factor expression and OA pathogenesis
Upregulated zinc importer ZIP8 in osteoarthritic cartilage causes cellular Zn2+ influx and MTF1 activation in chondrocytes, which, together, drive catabolic factor expression and osteoarthritis cartilage destruction.
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► The monodisperse and multigram-scale N-MCNPs are fabricated by carbonization of polypyrrole as a carbon precursor. ► The synthesized N-MCNPs provide an enhanced adsorption uptake ...for various heavy metal ions. ► The N-MCNPs can be applied to the Langmuir model and pseudo-second-order kinetics. ► The iron-impregnated N-MCNPs are reused up to 5 times with no loss of removal efficiency.
To clarify the heavy metal adsorption mechanism of nitrogen-doped magnetic carbon nanoparticles (N-MCNPs), adsorption capacity was investigated from the adsorption isotherms, kinetics and thermodynamics points of view. The obtained results showed that the equilibrium adsorption behavior of Cr
3+ ion onto the N-MCNPs can be applied to the Langmuir model and pseudo-second-order kinetics. It indicated that the fabricated N-MCNPs had the homogenous surface for adsorption and all adsorption sites had equal adsorption energies. Furthermore, the adsorption onto N-MCNPs taken place through a chemical process involving the valence forces. According to the thermodynamics, the adsorption process is spontaneous and endothermic in nature which means that the adsorption capacity increases with increasing temperature due to the enhanced mobility of adsorbate molecules. The effects of the solution pH and the species of heavy metal ion on the adsorption uptake were also studied. The synthesized N-MCNPs exhibited an enhanced adsorption capacity for the heavy metal ions due to the high surface area and large amount of nitrogen contents.
Objectives
To compare the clinical treatment outcomes of maxillary four‐implant retained overdentures with either splinted (bar) attachments or non‐splinted (ball) attachments.
Material and Methods
...Forty participants who were dissatisfied with their existing conventional maxillary complete dentures were included in this randomized controlled trial. Six months after implant placement, a definitive prosthesis was inserted. Implant success, condition of peri‐implant tissue, prosthodontic maintenance and complications, and patient satisfaction were assessed. Outcomes were recorded at baseline, prosthesis delivery, and at 3 and 12 months following prosthesis delivery, and a statistical analysis was performed.
Results
Thirty‐two of the forty patients completed the 1‐year follow‐up and had their treatment outcomes evaluated. The mean marginal bone loss after 1 year of loading was 0.34 ± 0.88 mm, and there were no significant differences between the two groups. Plaque index, gingival index and bleeding on probing were significantly higher in the bar group (p<.001), and the implant success rate of the bar group was significantly lower than that of the ball group (p=.028). The most frequent prosthodontic maintenance and complication issue was the need to change the bar clip or O‐ring as a result of retention loss. Patient satisfaction did not differ between the two groups except for aesthetics at 3 months.
Conclusions
Within the limitations of this study, the maxillary 4‐implant retained overdenture exhibited predictable results regardless of the attachment systems (ball or bar) in the 1‐year follow‐up period. The bar group was more vulnerable than the ball group with respect to maintaining peri‐implant tissue health.
Objective
This review evaluated the change in treatment outcomes after conversion from conventional removable partial denture (RPD) to implant‐assisted removable partial denture (IARPD). The ...patient‐reported outcome measures (PROMs), objective parameters for evaluation of functional performance, and biological and mechanical complication were evaluated.
Materials and Methods
This systematic review was based on the Cochrane review methodology and followed the criteria of the preferred reporting items for systematic reviews and meta‐analyses (PRISMA). We searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science, and Scopus up to April 3, 2019. After the initial search, additional electronic and hand searches were performed to identify further studies, ongoing studies, and gray literature, without restrictions on language, year of publication, or publication type.
Results
In total, 6,544 non‐duplicate articles were identified, and 31 were eligible for full‐text search. Finally, 19 publications based on 13 independent studies were selected. In the meta‐analysis, general patient satisfaction was significantly increased (p < .05), and the improved mastication was remarkable oral function. In oral health‐related quality of life, the oral health impact profile score was significantly improved, and improvements of physical pain and psychological disability were prominent (p < .05). Masticatory performance was improved in terms of maximum bite force, active occlusal contact area, and mandibular jaw movement (p < .05). The weighted mean survival rate of implants was 96.60%.
Conclusions
After conversion from conventional RPD to IARPD, the PROMs and masticatory performance significantly improved in partially edentulous patients under mandibular Kennedy classification I.
To address the demands of emerging data‐centric computing applications, ferroelectric field‐effect transistors (Fe‐FETs) are considered the forefront of semiconductor electronics owing to their ...energy and area efficiency and merged logic–memory functionalities. Herein, the fabrication and application of an Fe‐FET, which is integrated with a van der Waals ferroelectrics heterostructure (CuInP2S6/α‐In2Se3), is reported. Leveraging enhanced polarization originating from the dipole coupling of CIPS and α‐In2Se3, the fabricated Fe‐FET exhibits a large memory window of 14.5 V at VGS = ±10 V, reaching a memory window to sweep range of ≈72%. Piezoelectric force microscopy measurements confirm the enhanced polarization‐induced wider hysteresis loop of the double‐stacked ferroelectrics compared to single ferroelectric layers. The Landau–Khalatnikov theory is extended to analyze the ferroelectric characteristics of a ferroelectric heterostructure, providing detailed explanations of the hysteresis behaviors and enhanced memory window formation. The fabricated Fe‐FET shows nonvolatile memory characteristics, with a high on/off current ratio of over 106, long retention time (>104 s), and stable cyclic endurance (>104 cycles). Furthermore, the applicability of the ferroelectrics heterostructure is investigated for artificial synapses and for hardware neural networks through training and inference simulation. These results provide a promising pathway for exploring low‐dimensional ferroelectronics.
The authors report on the fabrication and application of a ferroelectric transistor integrated with a van der Waals ferroelectrics heterostructure (CuInP2S6/α‐In2Se3). Leveraging enhanced polarization originating from the dipole coupling, the fabricated device exhibits a large memory window and nonvolatile memory characteristics with long retention time and stable cyclic endurance, providing a promising pathway for exploring low‐dimensional ferroelectronics.
The aim of this systematic review was to compare treatment outcomes in terms of implant survival rate, marginal bone loss, and patient-reported outcome measures (PROMs) between narrow-diameter ...implants and regular-diameter implants (RDIs) for mandibular implant overdentures (MIOs).
This study was based on the methodology adapted as per Cochrane. Medline, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, and Scopus were searched for pertinent studies published by July 22, 2022. Outcome parameters included in this meta-analysis were implant survival rate, marginal bone loss, visual analogue scale score for patient satisfaction, and value of oral health impact profile.
A total of 782 non-duplicate articles and 83 clinical study registrations were identified from database and hand searches, of which 26 were eligible for full-text searches. Finally, 12 publications reporting on 8 independent studies were included in this review. In the meta-analysis, implant survival rate and marginal bone loss did not significantly differ between narrow-diameter implants and RDIs. Regarding RDIs, narrow-diameter implants were associated with significantly better outcomes in general patient satisfaction and oral health-related quality of life than RDIs for mandibular overdentures.
Narrow-diameter implants have competitive treatment outcomes compared to RDIs in terms of implant survival rate, marginal bone loss, and RDIs. Thus, narrow-diameter implants might be an alternative treatment option for MIOs in situations with limited alveolar bone volume.
Inhaler education for chronic obstructive pulmonary disease (COPD) patients improves inhaler technique and adherence. However, the effects of such education on the quality of life and inhaler ...satisfaction remain unclear. Here, we evaluated inhaler handling and adherence, and changes in quality of life and inhaler satisfaction, after repeated education for COPD patients. We prospectively enrolled COPD patients who had used inhalers for over 1 month and evaluated the effects of repeated education. Three visits were made over 6 months; an advanced practice nurse evaluated inhaler technique and adherence, and instructed the patients in inhaler technique during face-to-face sessions. Inhaler technique and adherence were assessed at every visits, and the modified Medical Research Council (mMRC) test, COPD Assessment Test (CAT), EuroQol-5D (EQ-5D), Patient Health Questionnaire (PHQ-9), and Feeling of Satisfaction with Inhaler questionnaire (FSI-10) were administered before (visit 1) and after two educational sessions (visit 3). A total of 261 COPD patients (308 inhalers) were included. Education significantly reduced the proportion of critical errors after two educational sessions (visit 3), from 43.2 to 8.8% (p < 0.001). The proportion of highly compliant patients increased after two visits, from 81.6% to 87.7% (p = 0.005). The FSI-10 score improved significantly after education, from 44.36 ± 4.69 to 47.64 ± 4.08 (p < 0.001); the scores on the other instruments (mMRC, CAT, EQ-5D, and PHQ-9) did not improve. Repeated face-to-face inhaler education by an advanced practice nurse significantly improved inhaler satisfaction, technique, and adherence. However, inhaler education did not significantly improve quality of life.
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