The products of erythrocyte lyses, haemoglobin (Hb) and haem, are recognized as neurotoxins and the main contributors to delayed cerebral oedema and tissue damage after intracerebral haemorrhage ...(ICH). Finding a means to efficiently promote absorption of the haemolytic products (Hb and haem) around the bleeding area in the brain through stimulating the function of the body's own garbage cleaning system is a novel clinical challenge and critical for functional recovery after ICH. In this review, available information of the brain injury mechanisms underlying ICH and endogenous haematoma scavenging system is provided. Meanwhile, potential intervention strategies are discussed. Intracerebral blood itself has ‘toxic’ effects beyond its volume effect after ICH. Haptoglobin–Hb–CD163 as well as haemopexin–haem–LRP1 is believed to be the most important endogenous scavenging pathway which participates in blood components resolution following ICH. PPARγ–Nrf2 activates the aforementioned clearance pathway and then accelerates haematoma clearance. Meanwhile, the scavenger receptors as novel targets for therapeutic interventions to treat ICH are also highlighted.
Aims/Introduction
Pregnant women with gestational diabetes mellitus (GDM) are at a higher risk of adverse pregnancy outcomes. The aim of the present study was to estimate the pooled prevalence of GDM ...in mainland China according to International Association of Diabetes and Pregnancy Study Groups criteria.
Materials and Methods
We carried out a systematic review by searching both English and Chinese literature databases. Random effects models were used to summarize the prevalence of GDM in mainland China. Subgroup and sensitivity analyses were carried out to address heterogeneity. Publication bias was evaluated using Egger's test.
Results
A total of 25 papers were included in the meta‐analysis, involving 79,064 Chinese participants. The total incidence of GDM in mainland China was 14.8% (95% confidence interval 12.8–16.7%). Subgroup analysis showed that the age, bodyweight and family history of diabetes mellitus could significantly increase the incidence of GDM.
Conclusions
To the best of our knowledge, this systematic review is the first to estimate the pooled prevalence of GDM among women in mainland China according to International Association of Diabetes and Pregnancy Study Groups criteria. The results of our systematic review suggest a high prevalence of GDM in mainland China, indicating that this country might have the largest number of GDM patients worldwide.
This systematic review is the first to estimate the pooled prevalence of GDM among subjects in mainland China according to IADPSG criteria. The results of our systematic review suggest a high prevalence of GDM in mainland China, indicating that this country may have the largest number of GDM patients worldwide.
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•CuS/KTN composite was prepared via a two-step hydrothermal method.•Vibration and solar energy were harvested to piezo-/photocatalytic N2 fixation.•CuS/KTN presented much better ...performance in photo-/piezocatalytic N2 fixation than KTN.•The high performance was mainly ascribed to the improved charge separation.
This work synthesized a novel CuS/KTa0.75Nb0.25O3 (KTN) heterojunction composite and firstly applied it in photocatalytic and piezocatalytic reduction of N2 to NH3. XRD, Raman, XPS, SEM, and TEM analyses indicate that CuS nanoparticles closely adhered to the surface of KTN nanorods, which facilitates the migration of electrons between the two semiconductors. Mott-Schottky and valence band XPS analysis shows that KNbO3 shows a higher conduction band than CuS, indicating that CuS mainly acts as electron trappers to capture the photogenerated electrons from KTN. Because of the great enhanced spatial separation of photogenerated charge carriers, the CuS/KTN presents much higher performance than pure KNT, which is further confirmed by 1H NMR analysis of the reaction solution. An interesting finding is that synthesized CuS/KTN not only performs well under light irradiation but also can work in an ultrasonic bath, indicating its great potential in photo/piezocatalytic conversion of N2 to NH3. The optimal 10 %CuS/KTN shows an NH3 production rate of 36.2 μmol L−1 g−1 h−1 under ultrasonic vibration, which reaches 7.4 times that of KTN. The electrons generated by KTN through the piezoelectric effect can be captured by CuS, which endows the electrons a longer life to participate in the reaction, thereby improving the catalytic reaction performance.
In order to prevent and control the infection of Candida albicans, the antifungal activity, possible mechanism of myriocin against C. albicans and its biofilm were studied. The antifungal activity of ...myriocin was investigated by microdilution method. The effect of myriocin on fungal cell wall or membrane was evaluated by adding sorbitol, ergosterol or phytosphingosine (PHS). The damage to the cell membrane was investigated with propidium iodide (PI) staining and visualized by scanning electron microscope (SEM). The effects on biofilms and extracellular polysaccharides (EPS) were observed by crystal violet staining method and phenol-sulfuric acid method respectively. The adhesion of C. albicans cells to hydrocarbons was tested to evaluate cell surface hydrophobic (CSH). The combined effects of myriocin and antifungal drugs commonly used in clinical practice were investigated by using the checkerboard microdilution method. Minimal inhibitory concentrations (MICs) were found to be 0.125–4 µg/mL. Myriocin was found to affect both cell wall and cell membrane. After exposure to myriocin, biofilm and EPS were found to be inhibited and removed, and the CSH was decreased. The combined fungistasis of myriocin and voriconazole (VCZ) or amphotericin B (AMB) were additive. Myriocin had significant antifungal activity against C. albicans, and the antifungal mechanisms might be cell wall and membrane damage. Myriocin effectively inhibited and eliminated biofilms, and its mechanism may be related to the inhibition of EPS and CSH.
This letter adopts long short-term memory (LSTM) to predict sea surface temperature (SST), and makes short-term prediction, including one day and three days, and long-term prediction, including ...weekly mean and monthly mean. The SST prediction problem is formulated as a time series regression problem. The proposed network architecture is composed of two kinds of layers: an LSTM layer and a full-connected dense layer. The LSTM layer is utilized to model the time series relationship. The full-connected layer is utilized to map the output of the LSTM layer to a final prediction. The optimal setting of this architecture is explored by experiments and the accuracy of coastal seas of China is reported to confirm the effectiveness of the proposed method. The prediction accuracy is also tested on the SST anomaly data. In addition, the model's online updated characteristics are presented.
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•The composite probiotics increased SCFA-producing bacteria and decreased Escherichia coli.•The composite probiotics promoted GLP-1 secretion by upregulation of GPR43/41, GCG and ...PC1/3 activity.•The composite probiotics inhibited apoptosis via regulating PI3K/AKT signaling pathways.
Previous studies have found that probiotic fermented camel milk has anti-diabetic effect by inducing (glucagon-like peptide-1) GLP-1 secretion. Probiotics are valuable in prevention and treatment of diabetes. As a result, our team islolated 14 probiotics from fermented camel milk. These probiotics have beneficial characteristics, but the possible anti-diabetic mechanisms remains unclear. The present study aimed to explore the possoble anti-diabetic mechanisms of 14 probiotics.
C57BL/Ks mice were normal group. The db/db mice were randomized into five groups: model group, metformin group, liraglutide group, low-dose and high-dose probiotic group. Biochemical parameters were determined by the respective assay kits. The levels of the short-chain fatty acids (SCFAs) and microbiota were respectively determined by gas chromatography and qRT-PCR. HE staining and immunofluorescence were used for histomorphological observation. Quantitative PCR and western-blot were determined the gene and protein expression of Bax, Bcl-2, Caspase-3 and PI3K/AKT.
Probiotics significantly improved blood glucose and blood lipid parameters, as well as the morphological changes of pancreas, liver and kidney. Probiotics improved the gut barrier function through increasing the levels of SCFA-producing bacteria and SCFAs as well as the expression of claudin-1 and mucin-2, and decreasing Escherichia coli and LPS level. In additon, probiotics enhanced insulin secretion through glucose-triggered GLP-1 secretion by upregulating G protein-coupled receptor 43/41 (GPR43/41), proglucagon and proconvertase 1/3 activity. Forthermore, probiotics protected pancreas against apoptosis, which may be dependent on the upregulation of PI3K/AKT pathway.
The anti-diabetic effect of 14 probiotics in db/db mice seem to be related to an increase of SCFA-producing bacteria, the improvement of intestinal barrier function and the upregulation of GLP-1 production, and indicate these probiotics might be a good candidate to prevent and treat diabetes.
This study summarizes the annual sales and market trends of plug-in electric vehicles in China from 2011 to 2017 at the national and ronal levels. The major performance characteristics of top-selling ...plug-in electric vehicle (PEV) models sold in China are summarized. Then, incentive policies of PEV adoption are explored at the provincial level in China. Approximately 70% of the total PEV model sales have lower all-electric ranges and battery capacity than average in the top 5 provinces that have sold the most battery electric vehicles (BEVs) or plug-in hybrid electric vehicles (PHEVs). Sales by make and model in these top 5 provinces are used to estimate ronal electricity consumption, gasoline replacement and carbon dioxide reductions. From 2011 to 2017, 682,047 PEVs have been sold in the 5 provinces, with 18.3 billion electric vehicle kilometers traveled (VKT). 3.0 TWh of electricity were consumed, reducing gasoline consumption by 1.6 billion liters and CO2 emissions by 611,824 tons. Approximately 70% of the total gasoline replacement and 80% of the total CO2 emissions reduction were contributed by BEVs. A sensitivity analysis is also conducted to assess the impacts of certain parameters on the results.
Developing high‐efficiency and cost‐effective alloy catalysts toward hydrogen‐evolution reaction (HER) is crucial for large‐scale hydrogen production via electrochemical water splitting, but ...conventional single‐principal‐element alloy design usually causes insufficient activity and durability of state‐of‐the‐art multimetallic catalysts based on non‐precious transition metals. Herein, we report multicomponent intermetallic Mo(NiFeCo)4 nanoparticles seamlessly integrated on hierarchical nickel network (Mo(NiFeCo)4/Ni) as robust hydrogen‐evolution electrocatalysts with remarkably improved activity and durability by making use of iron and cobalt atoms partially substituting nickel sites to form high‐entropy NiFeCo sublattice in intermetallic MoNi4 matrix, which serve as bifunctional electroactive sites for both water dissociation and adsorption/combination of hydrogen intermediate and improves thermodynamic stability. By virtue of bicontinuous nanoporous nickel skeleton facilitating electron/ion transportation, self‐supported nanoporous Mo(NiFeCo)4/Ni electrode exhibits exceptional HER electrocatalysis, with low Tafel slope (≈35 mV dec−1), high current density (≈2300 mA cm−2) at low overpotential (200 mV) and long‐term durability in 1 m KOH. When coupled to its electrooxidized and nitrified derivative for oxygen‐evolution reaction, their alkaline water electrolyzers operate with a superior overall water‐splitting output, outperforming the one constructed with commercially available noble‐metal‐based catalysts. These electrochemical properties make it an attractive candidate as electrocatalyst in alkaline water electrolysis for large‐scale hydrogen generation.
Multicomponent intermetallic Mo(NiFeCo)4 nanoparticles that are seamlessly integrated on hierarchical nanoporous nickel network (Mo(NiFeCo)4/Ni) hold great promise as low‐cost verstile electrocatalysts for highly efficient water splitting. Associated with hierarchical nanoporous architecture to facilitate electron transfer and offer abundant multicomponent intermetallic active sites, the self‐supported nanoporous Mo(NiFeCo)4/Ni electrode and its electrooxidized/nitrified derivative exhibit remarkably enhanced hydrogen‐evolution and oxygen‐evolution activities and durability.
Brain organoids have been used to recapitulate the processes of brain development and related diseases. However, the lack of vasculatures, which regulate neurogenesis and brain disorders, limits the ...utility of brain organoids. In this study, we induced vessel and brain organoids respectively, and then fused two types of organoids together to obtain vascularized brain organoids. The fused brain organoids were engrafted with robust vascular network-like structures, and exhibited increased number of neural progenitors, in line with the possibility that vessels regulate neural development. Fusion organoids also contained functional blood-brain-barrier (BBB)-like structures, as well as microglial cells, a specific population of immune cells in the brain. The incorporated microglia responded actively to immune stimuli to the fused brain organoids and showed ability of engulfing synapses. Thus, the fusion organoids established in this study allow modeling interactions between the neuronal and non-neuronal components
, in particular the vasculature and microglia niche.
Recently, sparse coding has been successfully applied in visual tracking. The goal of this paper is to review the state-of-the-art tracking methods based on sparse coding. We first analyze the ...benefits of using sparse coding in visual tracking and then categorize these methods into appearance modeling based on sparse coding (AMSC) and target searching based on sparse representation (TSSR) as well as their combination. For each categorization, we introduce the basic framework and subsequent improvements with emphasis on their advantages and disadvantages. Finally, we conduct extensive experiments to compare the representative methods on a total of 20 test sequences. The experimental results indicate that: (1) AMSC methods significantly outperform TSSR methods. (2) For AMSC methods, both discriminative dictionary and spatial order reserved pooling operators are important for achieving high tracking accuracy. (3) For TSSR methods, the widely used identity pixel basis will degrade the performance when the target or candidate images are not aligned well or severe occlusion occurs. (4) For TSSR methods, ℓ1 norm minimization is not necessary. In contrast, ℓ2 norm minimization can obtain comparable performance but with lower computational cost. The open questions and future research topics are also discussed.
► A comprehensive review of visual tracking based on sparse coding. ► Extensive experimental comparison between 15 state of the art tracking methods on a total of 20 challenging sequences. ► Analyze the benefits of using sparse coding in visual tracking. ► Point out the future research topics.
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