Abstract Background and Aims Globally, diabetes mellitus is one of the major causes of increased morbidity. One of the key complications of T2D is chronic kidney disease (CKD). Current evidence ...demonstrates that people with type 2 diabetes (T2D) are at a higher risk of developing chronic kidney disease (CKD) with greater morbidity and mortality. So, we aimed to find out the prevalence of CKD among T2DM patients and to evaluate the correlation between age, duration of diabetes, HbA1c, and UACR with eGFR among T2DM patients. Method An observational cross-sectional study was conducted at department of medicine, tertiary care hospital for 2 months. Along with demographic and anthropometric data The following clinical data were collected: estimated glomerular filtration rate (eGFR), serum creatinine, urinary albumin creatinine ratio (UACR), and HbA1c levels. Spearman rank correlation was used to determine the correlation between eGFR and various parameters. Results A total of 96 patients were included in the study. 65% of the study participants were sedentary and 35% were physically active. 41 (42.7%) were obese and 21 (21.9%) were overweight. The mean Duration of diabetes is 5.62 ± 4.68 years. The mean estimated glomerular filtration rate (eGFR) is 74.33 ± 31.01 mL/min/1.73 m2. The Prevalence of CKD is 35.4%. 21.8% belongs to G3a category and 8.3% belongs to G3b category. Spearman's correlation coefficient test revealed negative correlation between eGFR and duration of diabetes, HbA1c and UACR (Spearman's correlation coefficient values are −0.577, −0.595 and −0.709 respectively). Conclusion In conclusion, nearly 1/3rd of study participants reported CKD. Our study provides consistent and recent clinical data showing an inverse association of eGFR with age and duration of diabetes. This study highlights that age and duration of diabetes are key parameters associated with declining renal functions in people with T2DM.
Sports offer numerous health benefits, contributing to growth, development, physical fitness, and mental well-being. However, injuries are an inevitable part of sports, affecting both professional ...athletes and casual participants. The incidence of sports-related injuries has risen significantly due to increased participation, heightened competitiveness, inadequate injury prevention techniques, improper sporting gear, insufficient training, and overuse.
ology: A comprehensive literature search was performed in multiple databases such as PUBMED and SCOPUS. Relevant studies on therapeutic uses of platelet-rich plasma (PRP) in sports injuries were included. The findings provide a comprehensive overview of the topic.
Platelet-Rich Plasma (PRP) is a regenerative, minimally invasive, non-surgical procedure that accelerates healing by utilizing concentrated bioactive factors from the body. PRP has shown promising results in treating conditions such as patellar tendonitis, Achilles tendonitis, tennis elbow, partial rotator cuff tears, ligament tears, and mild to moderate arthritis. Following a PRP injection, athletes typically undergo a short period of rest from sports activities while attending rehabilitation therapy. This approach helps optimize healing and ensures an optimal outcome.
PRP has shown great promise as a treatment modality for sports injuries. While further research is needed to optimize PRP protocols and understand its mechanisms of action in sports injuries, it holds significant potential for enhancing the recovery and rehabilitation of athletes, ultimately contributing to improved outcomes in the field of sports medicine.
•CAR-T cell therapy has shown significant clinical responses in malignancies like B-cell leukaemia and lymphoma.•There are is very little research and limited number (just 2) trials conducted on CAR ...T-cell therapy in the Indian subcontinent. This is a cause for concern, given the proven efficacy of the therapy.•High cost, technical requirements, funding challenges, and lack of a complex workforce are limiting factors for conducting CAR-T cell therapy clinical trials in India.
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