Inflammatory bowel disease (IBD) including Crohn's disease (CD) and ulcerative colitis (UC), are associated with higher thrombotic risk and enhanced thrombin generation (TG) in adults. Despite ...encouraging data reporting vaccine safety and low IBD flare rates in adults with IBD, vaccine hesitancy was demonstrated to be high in families of children with IBD. We aimed to find out whether TG is increased in children with IBD as compared to healthy controls and whether TG parameters show significant changes following SARS-CoV-2 mRNA vaccination.
In this observational case-control study, 38 children with IBD (CD:18, UC: 20) aged 12-18 years and 62 healthy age-and sex-matched children were enrolled. Blood was collected before the first dose and 2-6 weeks after the second dose of BNT162b2 (Pfizer-BioNTech) mRNA vaccine dose. Blood cell counts, fibrinogen, inflammatory markers (hsCRP, ferritin), anti-SARS-CoV-2 antibody levels were investigated, TG assay was carried-out using platelet-poor plasma. Detailed clinical parameters including disease activity scores (PUCAI, PCDAI) were registered pre-and post- vaccination. A guided questionnaire was used to collect data on adverse reactions (AEs) post- vaccination.
Baseline TG parameters did not differ between patients and controls. Endogenous thrombin potential showed a significant positive correlation with markers of inflammation and with PCDAI. Inflammatory parameters and TG did not increase in patients and controls post-vaccination. Vaccination significantly increased antibody levels in all three investigated groups, but post-vaccination anti-SARS-CoV-2 S IgG/IgM levels were below the 5
percentile value of healthy children in more than one third of patients. Those receiving TNFα inhibitor therapy presented significantly lower SARS-CoV-2 S IgG/IgM levels as compared to patients on other immunosuppressive regimens. Systemic AEs did not differ between patients and controls while lower rate of local symptoms was found post-vaccination in children with IBD. Only 2 IBD flares were detected 2-6 weeks after the second dose of vaccination.
Our study is the first to support the safety and efficacy of anti-SARS-CoV-2 BNT162b2 vaccination in children with IBD with detailed pre-and post-vaccination laboratory data including TG. Results of this study may further increase confidence and reduce vaccine hesitancy in caretakers of pediatric IBD patients.
Analysis of MESSENGER magnetic field observations taken in the southern lobe of Mercury's magnetotail and the adjacent magnetosheath on 11 April 2011 indicates that a total of 163 flux transfer ...events (FTEs) occurred within a 25 min interval. Each FTE had a duration of ∼2–3 s and was separated in time from the next by ∼8–10 s. A range of values have been reported at Earth, with mean values near ∼1–2 min and ∼8 min, respectively. We term these intervals of quasiperiodic flux transfer events “FTE showers.” The northward and sunward orientation of the interplanetary magnetic field during this shower strongly suggests that the FTEs observed during this event formed just tailward of Mercury's southern magnetic cusp. The point of origin for the shower was confirmed with the Cooling model of FTE motion. Modeling of the individual FTE‐type flux ropes in the magnetosheath indicates that these flux ropes had elliptical cross sections, a mean semimajor axis of 0.15RM (where RM is Mercury's radius, or 2440 km), and a mean axial magnetic flux of 1.25 MWb. The lobe magnetic field was relatively constant until the onset of the FTE shower, but thereafter the field magnitude decreased steadily until the spacecraft crossed the magnetopause. This decrease in magnetic field intensity is frequently observed during FTE showers. Such a decrease may be due to the diamagnetism of the new magnetosheath plasma being injected into the tail by the FTEs.
Key Points
FTE showers at Mercury form new flux ropes every ~ 8‐10 s
Shower FTES have durations of ~2‐3 s and elliptical cross sections
FTEs forming in Mercury's cusp inject solar wind plasma into the tail
Electro-pneumatic actuators play an essential role in various areas of the industry, including heavy-duty vehicles. This article deals with the control problem of an Automatic Manual Transmission, ...where the actuator of the system is a double-acting floating-piston cylinder, with dedicated inner-position. During the control design of electro-pneumatic cylinders, one must implement a set-valued control on a nonlinear system, when, as in the present case, non-proportional valves provide the airflow. As both the system model itself and the qualitative control goals can be formulated as a Partially Observable Markov Decision Process, Machine learning frameworks are a conspicuous choice for handling such control problems. To this end, six different solutions are compared in the article, of which a new agent named PG-MCTS, using a modified version of the "Upper Confidence bound for Trees" algorithm, is also presented. The performance and strategic choice comparison of the six methods are carried out in a simulation environment. Validation tests performed on an actual transmission system and implemented on an automotive control unit to prove the applicability of the concept. In this case, a Policy Gradient agent, selected by implementation and computation capacity restrictions. The results show that the presented methods are suitable for the control of floating-piston cylinders and can be extended to other fluid mechanical actuators, or even different set-valued nonlinear control problems.
The paper presents the modeling and control design of a floating piston electro-pneumatic gearbox actuator and, moreover, the industrial validation of the controller system. As part of a heavy-duty ...vehicle, it needs to meet strict and contradictory requirements and units applying the system with different supply pressures in order to operate under various environmental conditions. Because of the high control frequency domain of the real system, post-modern control methods with high computational demands could not be used as they do not meet real-time requirements on automotive level. During the modeling phase, the essential simplifications are shown with the awareness of the trade-off between calculation speed and numerical accuracy to generate a multi-state piecewise-linear system. Two LTI control methods are introduced, i.e., a PD and an Linear-Quadratic Regulators (LQR) solution, in which the continuous control signals are transformed into discrete voltage solenoid commands for the valves. The validation of both the model and the control system are performed on a real physical implementation. The results show that both modeling and control design are suitable for the control tasks using floating piston cylinders and, moreover, these methods can be extended to electro-pneumatic cylinders with different layouts.
In general, slow solar wind from the streamer belt forms a high plasma β equatorial plasma sheet around the heliospheric current sheet (HCS) crossing, namely, the heliospheric plasma sheet (HPS). ...Current Parker Solar Probe (PSP) observations show that the HCS crossings near the Sun could be full or partial current sheet (PCS) crossings, and they share some common features but also have different properties. In this work, using the PSP observations from encounters 4–10, we identify streamer belt solar wind from enhancements in plasma β, and we further use electron pitch angle distributions to separate it into HPS solar wind around the full HCS crossings and PCS solar wind in the vicinity of PCS crossings. Based on our analysis, we find that the PCS solar wind has different characteristics as compared with HPS solar wind: (a) the PCS solar wind could be non-pressure-balanced structures rather than magnetic holes, and the total pressure enhancement mainly results from the less reduced magnetic pressure; (b) some of the PCS solar wind is mirror-unstable; and (c) the PCS solar wind is dominated by very low helium abundance but varied alpha–proton differential speed. We suggest that the PCS solar wind could originate from coronal loops deep inside the streamer belt, and it is pristine solar wind that still actively interacts with ambient solar wind; thus, it is valuable for further investigations of the heating and acceleration of slow solar wind.
Abstract Empirical data from previous investigations showed that emotion processing is reflected in beta, and especially in low beta event related desynchronization (ERD) (i.e. a decrease in low beta ...power). While recognition of social information and emotion processing are impaired in schizophrenia, no previous study analyzed induced and evoked beta oscillations in patients with schizophrenia during emotion processing. Twenty-eight subjects with schizophrenia and twenty-seven healthy controls subjects were enrolled in the study. The two study groups did not differ in age, gender and education. Participants viewed positive, neutral and negative scenes selected from the International Affective Picture System (IAPS) while 128-channel EEG was recorded. A significantly weaker low beta ERD was detected in patients relative to controls for the negative stimulus condition in the right parieto-occipital and temporal regions. Patients with decreased beta ERD showed more prominent negative symptoms and more severe deficits in psychosocial functioning. Only in the control group stronger beta ERD was detected for the negative stimuli relative to positive and neutral stimuli in the same regions. Our major finding is that impaired emotion processing in schizophrenia is reflected in decreased low beta ERD and in the diminished differences between low beta ERD to negative and non-negative emotional stimuli. Furthermore, it was found that patients with decreased beta ERD show more prominent negative symptoms and more severe deficits in psychosocial functioning.
Bacillus subtilis spores, representatives of an exceptionally resistant dormant cell type, are encircled by a thick proteinaceous layer called the spore coat. More than 80 proteins assemble into four ...distinct coat layers: a basement layer, an inner coat, an outer coat and a crust. As the spore develops inside the mother cell, spore coat proteins synthesized in the cytoplasm are gradually deposited onto the prespore surface. A small set of morphogenetic proteins necessary for spore coat morphogenesis are thought to form a scaffold to which the rest of the coat proteins are attached. Extensive localization and proteomic studies using wild type and mutant spores have revealed the arrangement of individual proteins within the spore coat layers. In this study we examined the interactions between the proteins localized to the outer coat and crust using a bacterial two hybrid system. These two layers are composed of at least 25 components. Self-interactions were observed for most proteins and numerous novel interactions were identified. The most interesting contacts are those made with the morphogenetic proteins CotE, CotY and CotZ; these could serve as a basis for understanding the specific roles of particular proteins in spore coat morphogenesis.
Generally, the interpretation of functional MRI (fMRI) activation maps continues to rely on assessing their relationship to anatomical structures, mostly in a qualitative and often subjective way. ...Recently, the existence of persistent and stable brain networks of functional nature has been revealed; in particular these so-called intrinsic connectivity networks (ICNs) appear to link patterns of resting state and task-related state connectivity. These networks provide an opportunity of functionally-derived description and interpretation of fMRI maps, that may be especially important in cases where the maps are predominantly task-unrelated, such as studies of spontaneous brain activity e.g. in the case of seizure-related fMRI maps in epilepsy patients or sleep states. Here we present a new toolbox (ICN_Atlas) aimed at facilitating the interpretation of fMRI data in the context of ICN. More specifically, the new methodology was designed to describe fMRI maps in function-oriented, objective and quantitative way using a set of 15 metrics conceived to quantify the degree of ‘engagement’ of ICNs for any given fMRI-derived statistical map of interest. We demonstrate that the proposed framework provides a highly reliable quantification of fMRI activation maps using a publicly available longitudinal (test-retest) resting-state fMRI dataset. The utility of the ICN_Atlas is also illustrated on a parametric task-modulation fMRI dataset, and on a dataset of a patient who had repeated seizures during resting-state fMRI, confirmed on simultaneously recorded EEG. The proposed ICN_Atlas toolbox is freely available for download at http://icnatlas.com and at http://www.nitrc.org for researchers to use in their fMRI investigations.
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•fMRI activation maps are usually described in relation to anatomical structures.•ICN_Atlas describes fMRI data in the framework of intrinsic connectivity networks (ICN).•ICN_Atlas output: ICN ‘engagement’ (spatial and activation strength) metrics.•ICN_Atlas shows high ICN engagement reliability on test-retest resting-state fMRI data.•Method demonstrated (1) on parametric task-modulation fMRI data set shows differential engagement of ICN with respect to task difficulty, and (2) on epileptic seizure EEG-fMRI data shows compelling evolution of ICN engagement patterns.
Background and Objectives: Subcortical grey matter structures play essential roles in cognitive, affective, social, and motoric functions in humans. Their volume changes with age, and decreased ...volumes have been linked with many neuropsychiatric disorders. The aim of our study was to examine the heritability of six subcortical brain volumes (the amygdala, caudate nucleus, pallidum, putamen, thalamus, and nucleus accumbens) and four general brain volumes (the total intra-cranial volume and the grey matter, white matter, and cerebrospinal fluid (CSF) volume) in twins. Materials and Methods: A total of 118 healthy adult twins from the Hungarian Twin Registry (86 monozygotic and 32 dizygotic; median age 50 ± 27 years) underwent brain magnetic resonance imaging. Two automated volumetry pipelines, Computational Anatomy Toolbox 12 (CAT12) and volBrain, were used to calculate the subcortical and general brain volumes from three-dimensional T1-weighted images. Age- and sex-adjusted monozygotic and dizygotic intra-pair correlations were calculated, and the univariate ACE model was applied. Pearson’s correlation test was used to compare the results obtained by the two pipelines. Results: The age- and sex-adjusted heritability estimates, using CAT12 for the amygdala, caudate nucleus, pallidum, putamen, and nucleus accumbens, were between 0.75 and 0.95. The thalamus volume was more strongly influenced by common environmental factors (C = 0.45−0.73). The heritability estimates, using volBrain, were between 0.69 and 0.92 for the nucleus accumbens, pallidum, putamen, right amygdala, and caudate nucleus. The left amygdala and thalamus were more strongly influenced by common environmental factors (C = 0.72−0.85). A strong correlation between CAT12 and volBrain (r = 0.74−0.94) was obtained for all volumes. Conclusions: The majority of examined subcortical volumes appeared to be strongly heritable. The thalamus was more strongly influenced by common environmental factors when investigated with both segmentation methods. Our results underline the importance of identifying the relevant genes responsible for variations in the subcortical structure volume and associated diseases.
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