The circadian clock mechanism in animals involves a transcriptional feedback loop in which the bHLH‐PAS proteins CLOCK and BMAL1 form a transcriptional activator complex to activate the transcription ...of the Period and Cryptochrome genes, which in turn feed back to repress their own transcription. In the mouse liver, CLOCK and BMAL1 interact with the regulatory regions of thousands of genes, which are both cyclically and constitutively expressed. The circadian transcription in the liver is clustered in phase and this is accompanied by circadian occupancy of RNA polymerase II recruitment and initiation. These changes also lead to circadian fluctuations in histone H3 lysine4 trimethylation (H3K4me3) as well as H3 lysine9 acetylation (H3K9ac) and H3 lysine27 acetylation (H3K27ac). Thus, the circadian clock regulates global transcriptional poise and chromatin state by regulation of RNA polymerase II.
High-energy isolated attosecond pulses required for the most intriguing nonlinear attosecond experiments as well as for attosecond-pump/attosecond-probe spectroscopy are still lacking at present. ...Here we propose and demonstrate a robust generation method of intense isolated attosecond pulses, which enable us to perform a nonlinear attosecond optics experiment. By combining a two-colour field synthesis and an energy-scaling method of high-order harmonic generation, the maximum pulse energy of the isolated attosecond pulse reaches as high as 1.3 μJ. The generated pulse with a duration of 500 as, as characterized by a nonlinear autocorrelation measurement, is the shortest and highest-energy pulse ever with the ability to induce nonlinear phenomena. The peak power of our tabletop light source reaches 2.6 GW, which even surpasses that of an extreme-ultraviolet free-electron laser.
Expansion of the wavelength range for an ultrafast laser is an important ingredient for extending its range of applications. Conventionally, optical parametric amplification (OPA) has been employed ...to expand the laser wavelength to the infrared (IR) region. However, the achievable pulse energy and peak power have been limited to the mJ and the GW level, respectively. A major difficulty in the further energy scaling of OPA results from a lack of suitable large nonlinear crystals. Here, we circumvent this difficulty by employing a dual-chirped optical parametric amplification (DC-OPA) scheme. We successfully generate a multi-TW IR femtosecond laser pulse with an energy of 100 mJ order, which is higher than that reported in previous works. We also obtain excellent energy scaling ability, ultrashort pulses, flexiable wavelength tunability, and high-energy stability, which prove that DC-OPA is a superior method for the energy scaling of IR pulses to the 10 J/PW level.
Yarrowia lipolytica is a nonpathogenic dimorphic aerobic yeast that stands out due to its ability to grow in hydrophobic environments. This property allowed this yeast to develop an ability to ...metabolize triglycerides and fatty acids as carbon sources. This feature enables using this species in the bioremediation of environments contaminated with oil spill. In addition, Y. lipolytica has been calling the interest of researchers due to its huge biotechnological potential, associated with the production of several types of metabolites, such as bio-surfactants, γ-decalactone, citric acid, and intracellular lipids and lipase. The production of a metabolite rather than another is influenced by the growing conditions to which Y. lipolytica is subjected. The choice of carbon and nitrogen sources to be used, as well as their concentrations in the growth medium, and the careful determination of fermentation parameters, pH, temperature, and agitation (oxygenation), are essential for efficient metabolites production. This review discusses the biotechnological potential of Y. lipolytica and the best growing conditions for production of some metabolites of biotechnological interest.
We reveal experimentally waveguiding characteristics and group-velocity dispersion of line defects in photonic crystal slabs as a function of defect widths. The defects have waveguiding modes with ...two types of cutoff within the photonic band gap. Interference measurements show that they exhibit extraordinarily large group dispersion, and we found waveguiding modes whose traveling speed is 2 orders of magnitude slower than that in air. These characteristics can be tuned by controlling the defect width, and the results agree well with theoretical calculations, indicating that we can design light paths with made-to-order dispersion.
Context.
The discovery of an extrasolar planet with an ocean has crucial importance in the search for life beyond Earth. The polarimetric detection of specularly reflected light from a smooth liquid ...surface is anticipated theoretically, though the polarimetric signature of Earth’s oceans has not yet been conclusively detected in disk-integrated planetary light.
Aims.
We aim to detect and measure the polarimetric signature of the Earth’s oceans.
Methods.
We conducted near-infrared polarimetry for lunar Earthshine and collected data on 32 nights with a variety of ocean fractions in the Earthshine-contributing region.
Results.
A clear positive correlation was revealed between the polarization degree and ocean fraction. We found hourly variations in polarization in accordance with rotational transition of the ocean fraction. The ratios of the variation to the typical polarization degree were as large as ~0.2–1.4.
Conclusions.
Our observations provide plausible evidence of the polarimetric signature attributed to Earth’s oceans. Near-infrared polarimetry may be considered a prospective technique in the search for exoplanetary oceans.
Rigid polyurethane composite foams were prepared with cellulose fibers as a filler. The cellulose fibers were an industrial residue of blanched cellulose pulp production. The influence of the ...cellulose fiber concentration on the structural, thermal, mechanical, and morphological properties of the foams was investigated. We also studied the influence of the cellulose fibers on the foam's resistance to fungal attack by placing a suspension of known fungus in contact with the surface of the foam and following the morphological evolution as a function of time (for 60 days). The increase in the cellulose filler concentration in the foams, up to 16% w/w with respect to the polyol, changed their properties as follows: (1) the cell size decreased, (2) the thermooxidative stability and mechanical properties remained approximately constant, (3) the thermal conductivity decreased slightly, and (4) fungal growth was observed. Therefore, a cellulosic fibrous industrial residue was rationally valorized as a filler in classical rigid polyurethane foams; this yielded materials with mechanical resistance and a susceptibility to fungi in a wet environment.
High-energy infrared (IR) femtosecond laser sources are important for applications in ultrafast and strong-field laser science; thus, considerable effort has recently been made to develop such laser ...systems. In this paper, we review our recent work on developing TW-class mid-infrared (MIR) femtosecond laser pulses in the 1-4 <inline-formula><tex-math notation="LaTeX">\mu</tex-math></inline-formula>m region using a dual-chirped optical parametric amplification (DC-OPA) method. By employing a Ti:sapphire laser with sub-joule energy to pump the DC-OPA system, MIR femtosecond pulses with 100-mJ-class energy are demonstrated. Efficient energy scalability and flexible wavelength tunability in DC-OPA are confirmed experimentally. Different features of DC-OPA from those of conventional OPA and narrow-band pumped optical parametric chirped pulse amplification (OPCPA) are observed. By precisely optimizing the chirps of the seed and pump pulses in the DC-OPA system, bandwidth narrowing of amplified pulses can be minimized in an energy-scaling strategy. Moreover, DC-OPA can be universally employed for the energy scaling of near-IR, MIR, and far-IR pulses, regardless of the type of nonlinear crystal, and is helpful for efficiently generating few-cycle carrier-envelope phase stable IR pulses with TW-class peak power.
We report the beam energy (sqrtsNN=7.7-200 GeV) and collision centrality dependence of the mean (M), standard deviation (σ), skewness (S), and kurtosis (κ) of the net-proton multiplicity ...distributions in Au+Au collisions. The measurements are carried out by the STAR experiment at midrapidity (|y|<0.5) and within the transverse momentum range 0.4<pT<0.8 GeV/c in the first phase of the Beam Energy Scan program at the Relativistic Heavy Ion Collider. These measurements are important for understanding the quantum chromodynamic phase diagram. The products of the moments, Sσ and κσ2, are sensitive to the correlation length of the hot and dense medium created in the collisions and are related to the ratios of baryon number susceptibilities of corresponding orders. The products of moments are found to have values significantly below the Skellam expectation and close to expectations based on independent proton and antiproton production. The measurements are compared to a transport model calculation to understand the effect of acceptance and baryon number conservation and also to a hadron resonance gas model.
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