Plant-extracted triterpenoids belong to a class of bioactive compounds with pleotropic functions, including antioxidant, anti-cancer, and anti-inflammatory effects. In this work, we investigated the ...anti-inflammatory and anti-oxidative activities of a semisynthetic derivative of 18βH-glycyrrhetinic acid (18βH-GA), soloxolone methyl (methyl 2-cyano-3,12-dioxo-18βH-olean-9(11),1(2)-dien-30-oate, or SM) in vitro on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and in vivo in models of acute inflammation: LPS-induced endotoxemia and carrageenan-induced peritonitis. SM used at non-cytotoxic concentrations was found to attenuate the production of reactive oxygen species and nitric oxide (II) and increase the level of reduced glutathione production by LPS-stimulated RAW264.7 cells. Moreover, SM strongly suppressed the phagocytic and migration activity of activated macrophages. These effects were found to be associated with the stimulation of heme oxigenase-1 (HO-1) expression, as well as with the inhibition of nuclear factor-κB (NF-κB) and Akt phosphorylation. Surprisingly, it was found that SM significantly enhanced LPS-induced expression of the pro-inflammatory cytokines interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) in RAW264.7 cells via activation of the c-Jun/Toll-like receptor 4 (TLR4) signaling axis. In vivo pre-exposure treatment with SM effectively inhibited the development of carrageenan-induced acute inflammation in the peritoneal cavity, but it did not improve LPS-induced inflammation in the endotoxemia model.
The process e+e−→K+K− has been studied using 1.7×106 events from a data sample corresponding to an integrated luminosity of 5.7 pb−1 collected with the CMD-3 detector in the center-of-mass energy ...range 1010–1060 MeV. The cross section is measured with about 2% systematic uncertainty and is used to calculate the contribution to the anomalous magnetic moment of the muon aμK+K−=(19.33±0.40)×10−10, and to obtain the ϕ(1020) meson parameters. We consider the relationship between the e+e−→K+K− and e+e−→KS0KL0 cross sections and compare it to the theoretical prediction.
To control the parameters of PIN photodiodes during their mass production, a high-performance automated multifunctional stand has been developed. The stand provides measurement of dark current, ...capacitance at operating voltage, and response to a light signal with simultaneous connection of up to 16 photodiodes and successive verification of their characteristics.
Using the 1.32
pb
-
1
statistics collected at the
J
/
ψ
peak with the KEDR detector at the VEPP-4M
e
+
e
-
collider, we measured the branching fractions of
J
/
ψ
meson decays to the final states 2(
π
...+
π
-
)
π
0
,
K
+
K
-
π
+
π
-
π
0
, 2(
π
+
π
-
)
and
K
+
K
-
π
+
π
-
. The results obtained for the decays
J
/
ψ
→
2(
π
+
π
-
)
π
0
,
J
/
ψ
→
K
+
K
-
π
+
π
-
π
0
contradict the measurements performed by other groups in the last century, but agree well with recent results of BABAR and BESIII collaborations.
PID system based on focusing aerogel RICH for the super C-τ factory Barnyakov, A.Yu; Barnyakov, M.Yu; Boborovnikov, V.S. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
02/2020, Volume:
952
Journal Article
Peer reviewed
A high performance particle identification (PID) system is essential for the successful realization of the broad physics program at the future Super C-τ Factory in Novosibirsk. The main requirements ...for the PID system are as follows: good π/K-separation in the entire operational momentum range and good μ∕π-separation in the momentum range from 0.3 to 1.2 GeV/c. The RICH detector based on focusing aerogel radiator (FARICH) and position-sensitive photon detector meets all these requirements. The FARICH method is described, and the beam test results are presented. The FARICH system design outline for the Super C-τ Factory project is presented. Most promising photon detector options are considered.
The process e+e−→K+K−π+π− has been studied in the center-of-mass energy range from 1500 to 2000 MeV using a data sample of 23 pb−1 collected with the CMD-3 detector at the VEPP-2000 e+e− collider. ...Using about 24 000 selected events, the e+e−→K+K−π+π− cross section has been measured with a systematic uncertainty decreasing from 11.7% at 1500–1600 MeV to 6.1% above 1800 MeV. A preliminary study of K+K−π+π− production dynamics has been performed.
Beam test of FARICH prototype with digital photon counter Barnyakov, A.Yu; Barnyakov, M.Yu; Bobrovnikov, V.S. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
12/2013, Volume:
732
Journal Article
Peer reviewed
In June 2012 we tested a Focusing Aerogel RICH detector prototype based on Digital Photon Counters (DPC) by Philips at the CERN PS T10 beam line with a particle momentum up to 6GeV/c. The prototype ...comprises a 20×20cm2 photon detector with 48×48 DPC pixels. In order to reduce the dark count rate, the photon detector was cooled to −40°C in addition to disabling individual DPC's microcells. A four layer focusing aerogel radiator with 200mm focal distance was studied. We obtained a Cherenkov angle resolution of 3.61±0.04mrad. The mean number of photoelectrons in a ring is 12. Directly measured π/K separation at 6GeV/c momentum is 3.5σ, μ/π separation is 5.3σ at 1GeV/c. A comparison with a Monte Carlo simulation is presented as well.
•Focusing Aerogel RICH prototype with Digital Photon Counters by Philips was built.•The prototype was tested at the CERN PS T10 beam line.•We observed Cherenkov rings with 12 photoelectrons in average.•Timing resolution of DPCs is 48ps for single photons.•Cherenkov angle resolution is 3.64±0.04mrad per ring.
Proton–proton collisions at
TeV and heavy ion collisions at
TeV were produced by the LHC and recorded using the ATLAS experiment’s trigger system in 2010. The LHC is designed with a maximum bunch ...crossing rate of 40 MHz and the ATLAS trigger system is designed to record approximately 200 of these per second. The trigger system selects events by rapidly identifying signatures of muon, electron, photon, tau lepton, jet, and
B
meson candidates, as well as using global event signatures, such as missing transverse energy. An overview of the ATLAS trigger system, the evolution of the system during 2010 and the performance of the trigger system components and selections based on the 2010 collision data are shown. A brief outline of plans for the trigger system in 2011 is presented.
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