Feynman's path integral approach is to sum over all possible spatiotemporal paths to reproduce the quantum wave function and the corresponding time evolution, which has enormous potential to reveal ...quantum processes in the classical view. However, the complete characterization of the quantum wave function with infinite paths is a formidable challenge, which greatly limits the application potential, especially in the strong-field physics and attosecond science. Instead of brute-force tracking every path one by one, here we propose a deep-learning-performed strong-field Feynman's formulation with a preclassification scheme that can predict directly the final results only with data of initial conditions, so as to attack unsurmountable tasks by existing strong-field methods and explore new physics. Our results build a bridge between deep learning and strong-field physics through Feynman's path integral, which would boost applications of deep learning to study the ultrafast time-dependent dynamics in strong-field physics and attosecond science and shed new light on the quantum-classical correspondence.
To support multi-source data stream generated from Internet of Things devices, edge computing emerges as a promising computing pattern with low latency and high bandwidth compared to cloud computing. ...To enhance the performance of edge computing within limited communication and computation resources, we study a cloud-edge-end computing architecture, where one cloud server and multiple computational access points can collaboratively process the compute-intensive data streams that come from multiple sources. Moreover, a multi-source environment is considered, in which the wireless channel and the characteristic of the data stream are time-varying. To adapt to the dynamic network environment, we first formulate the optimization problem as a markov decision process and then decompose it into a data stream offloading ratio assignment sub-problem and a resource allocation sub-problem. Meanwhile, in order to reduce the action space, we further design a novel approach that combines the proximal policy optimization (PPO) scheme with convex optimization, where the PPO is used for the data stream offloading assignment, while the convex optimization is employed for the resource allocation. The simulated outcomes in this work can help the development of the application of the multi-source data stream.
In recent years, there have been an increasing number of studies on trigeminal neuralgia (TN). However, a scientific and comprehensive study of the current situation and trends in the field of TN ...research is lacking. The purpose of this study is to summarize and visualize the development, research hotspots, and future trends in TN based on a bibliometric approach.
Studies on TN published from 2001 to 2021 were obtained from the Web of Science Core Collection (WoSCC). Bibliometrics, CiteSpace, and VOSviewer tools were used for bibliometric analysis and visualization.
In total, 4,112 documents were searched. The number of research articles in the field is generally on an upward trend, with the fastest growth in the number of articles from 2017 to 2020. Shanghai Jiao Tong University, Pittsburgh University, and Mayo Clinic are the three institutions with the most publications. Shiting Li and Zakrzewska JM are the most prolific author and top co-cited authors, respectively.
is the most influential journal. The top 5 keywords in that time frame are TN, microvascular decompression, facial pain, stereotactic radiosurgery, and neuropathic pain.
This is the first comprehensive scientific bibliometric analysis of the global research field on TN over the past 21 years, providing a meaningful reference for further exploration of topical issues and research trends in the field.
Feedback control is a critical element in many Internet services (e.g., quality-of-service aware applications). Recent research has demonstrated the vulnerability of some feedback-control based ...applications to low-rate denial-of-service (LRDoS) attacks, which send high-intensity requests in an ON/OFF pattern to degrade the victim's performance and evade the detection designed for traditional DoS attacks. However, the intricate interaction between LRDoS attacks and the feedback control mechanism remains largely unknown. In this paper, we address two fundamental questions: 1) what is the impact of an LRDoS attack on a general feedback-control based system and 2) how to conduct a systematic evaluation of the impact of an LRDoS attack on specific feedback-control based systems. To tackle these problems, we model the system under attack as a switched system and then examine its properties. We conduct the first theoretical investigation on the impact of the LRDoS attack on a general feedback control system. We formally show that the attack can make the system's steady-state error oscillate along with the attack period, and prove the existence of LRDoS attacks that can force the system to be far off the desired state. In addition, we propose a novel methodology to systematically characterize the impact of an LRDoS attack on specific systems, and apply it to a web server and an IBM Notes server. This investigation obtains many new insights, such as new attack scenarios, the bound of the system's states, the relationship between the bound and the LRDoS attacks, the close-formed equations for quantifying the impact, and so on. The extensive experimental results are congruent with the theoretical analysis.
As an alternative preservation method to thermal treatment, ultrasound is a novel non-thermal processing technology that can significantly avoid undesirable nutritional changes. However, recently ...literature indicated that anthocyanin degradation occurred when high amplitude ultrasound was applied to juice. This work mainly studied the effect of ultrasound on the stability and antioxidant capacity of pelargonidin-3-glucoside (Pg-3-glu) and the correlation between anthocyanin degradation and •OH generation in a simulated system. Results indicated that the spectral intensities of Pg-3-glu decreased with increasing ultrasound power (200-500 W) and treatment time (0-60 min). The degradation trend was consistent with first-order reaction kinetics (R² > 0.9100). Further study showed that there was a good linear correlation between Pg-3-glu degradation and •OH production (R² = 0.8790), which indicated the important role of •OH in the degradation of anthocyanin during ultrasound exposure. Moreover, a decrease in the antioxidant activity of solution(s) containing Pg-3-glu as evaluated by the DPPH and FRAP methods was observed after ultrasound treatment.
The use of highly mineralized reinjection water has low gel strength and poor stability, and the above problems are more prominent under high-temperature reservoir conditions. Based on the ...temperature resistance and salt tolerance polymer TSRP and phenolic resin crosslinking agent, a TSRP temperature resistant weak gel system suitable for high mineralized reinjection water was developed, and the temperature resistance mechanism of the TSRP weak gel system was tested by its temperature resistance and injection ability. The migration, retention, and plugging of the TSRP weak gel system in heterogeneous reservoirs were studied through micropore throat migration and plugging characteristics and dual-pipe parallel oil displacement experiments. The results showed that: under the condition of polymer concentration 2000 mg/L, polymer: crosslinking agent: glue promoter 1:1.5:1, the TSRP weak gel system prepared by using mineralized 12132.9 mg/L reinjection water can remain stable after 95°C aging at high temperature of TSRP. Through microscopic simulation, a glass etching model TSRP weak gel system showed good migration ability and plugging performance. In comparison with the two pipes parallel oil displacement experiment, the KY gel system injected the same amount of PV at 95°C and 20000 mg/L in the Y1L block, the average recovery of the TSRP gel system increased by 22.3% after injection of polymer gel, and the KY gel system was only 18.2%; When the same amount of PV was injected in Z1L block, 95°C and 22000 mg/L, the average recovery of TSRP gel system increased by 24.35% after injection of polymer gel, and the KY gel system was only 17.15%, that is, under higher salinity, the TSRP gel system showed better performance.
The pterional keyhole approach is a more recently introduced minimally invasive version of the traditional pterional approach for treating aneurysms of the anterior circulation.
In this study, we ...compared operative parameters and clinical outcomes in patients treated with the pterional keyhole approach and historical controls in whom the traditional pterional approach was used. We reviewer records of 356 patients treated with the pterional keyhole approach between 2009 and 2016, along with those of 301 patients treated via the traditional pterional approach at the same period who served as a control group. The clinical manifestations, surgical details, postoperative complications, and modified Rankin Scale scores in the 2 groups were retrospectively compared.
There were 408 aneurysms in the study group and 362 aneurysms in the control group. In the pterional keyhole group, the total clipping ratio was 93.6%, leaving a remnant/wrapping rate of 6.37%, compared with 93.9% and 6.08%, respectively, in the standard pterional group. In the patients treated via the keyhole approach, the mean bone flap diameter was 4 × 3 cm, mean blood loss was 204 ± 100 mL, mean operation time was 160 ± 57 minutes, and mean length of stay was 8.32 ± 2.72 days, compared with control group parameters of 5 × 6 cm, 284 ± 150 mL, 180 ± 49 minutes, and 11.32 ± 2.48 days, respectively. At a 6-month follow-up, 71.1% had a favorable outcome, 25.8% had a poor outcome, and the mortality was 3.09%, compared with 68.1%, 29.9% and 1.99%, respectively, in the control group.
The pterional keyhole approach offers shorter operative times, less blood loss, shorter length of stay, and improved cosmesis without sacrificing outcomes compared with traditional pterional craniotomy.
•Various approaches are available to deal with ruptured intracranial aneurysms.•A pterional keyhole approach is optimal for ruptured aneurysms of anterior circulation.•This keyhole approach has shown better outcomes than the pterional approach.
Pituitary adenoma (PA) is a benign neuroendocrine tumor caused by adenohypophysial cells, and accounts for 10%-20% of all primary intracranial tumors. The surgical outcomes and prognosis of giant ...pituitary adenomas measuring ≥3 cm in diameter differ significantly due to the influence of multiple factors such as tumor morphology, invasion site, pathological characteristics and so on. The aim of this study was to explore the risk factors related to the recurrence or progression of giant and large PAs after transnasal sphenoidal surgery, and develop a predictive model for tumor prognosis.
The clinical and follow-up data of 172 patients with large or giant PA who underwent sphenoidal surgery at the Second Affiliated Hospital of Zhejiang University School of Medicine from January 2011 to December 2017 were retrospectively analyzed. The basic clinical information (age, gender, past medical history etc.), imaging features (tumor size, invasion characteristics, extent of resection etc.), and histopathological characteristics (pathological results, Ki-67, P53 etc.) were retrieved. SPSS 21.0 software was used for statistical analysis, and the R software was used to establish the predictive nomogram.
Seventy out of the 172 examined cases (40.7%) had tumor recurrence or progression. The overall progress free survival (PFS) rates of the patients at 1, 3 and 5 years after surgery were 90.70%, 79.65% and 59.30% respectively. Log-rank test indicated that BMI (P < 0.001), Knosp classification (P < 0.001), extent of resection (P < 0.001), Ki-67 (P < 0.001), sphenoidal sinus invasion (P = 0.001), Hardy classification (P = 0.003) and smoking history (P = 0.018) were significantly associated with post-surgery recurrence or progression. Cox regression analysis further indicated that smoking history, BMI ≥25 kg/m
, Knosp classification grade 4, partial resection and ≥3% Ki-67 positive rate were independent risk factors of tumor recurrence or progression (P < 0.05). In addition, the nomogram and ROC curve based on the above results indicated significant clinical value.
The postoperative recurrence or progression of large and giant PAs is related to multiple factors and a prognostic nomogram based on BMI (≥25 kg/m
), Knosp classification (grade 4), extent of resection (partial resection) and Ki-67 (≥3%) can predict the recurrence or progression of large and giant PAs after transnasal sphenoidal surgery.
To observe whether different insulin glargine titration algorithms based on fasting blood glucose (FBG) levels lead to different glycaemic variations (GVs) in type 2 diabetes (T2D) patients, a ...prospective, randomized, single-centre, comparative, three-arm parallel-group, open-label, treat-to-target, 24-week study was performed. A total of 71 uncontrolled T2D patients were recruited and randomized 1 : 3 : 3 into Groups 1, 2, and 3 (insulin titration goals of FBG≤5.6, ≤6.1, and ≤7.0) for this study. The initiated insulin glargine dose was recommended at 0.2 U/kg/day and was then titrated following the FBG target. Patients were subjected to two 3-day continuous glucose monitoring (CGM) at baseline and the endpoint, wherein the CGM data were analysed, and the study’s primary endpoint was the difference in 24 hrs mean amplitude of glycaemic excursion (MAGE) among the three groups. We observed that patients in the three groups had similar MAGE levels at the endpoint; however, Group 2 achieved a significant decrease in the MAGE level from baseline to the endpoint as compared to Groups 1 and 3 (all p<0.05). We also observed that these patients had significant glycated haemoglobin A1c (HbA1c) value improvements as compared to the other two groups (all p<0.05). Therefore, choosing an FBG level of 6.1 mmol/L as an insulin titration target provided significant GVs and HbA1c value improvements in T2D patients. Moreover, our data indicated that an FBG of 6.1 mmol/L could possibly be an insulin glargine titration target in T2D patients.
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