A novel architecture of 3D graphene growth on porous Al2O3 ceramics is proposed for thermal management using ambient pressure chemical vapor deposition. The formation mechanism of graphene is ...attributed to the carbothermic reduction occurring at the Al2O3 surface to initialize the nucleation and growth of graphene. The graphene films are coated on insulating anodic aluminum oxide (AAO) templates and porous Al2O3 ceramic substrates. The graphene coated AAO possesses one‐dimensional isolated graphene tubes, which can act as the media for directional thermal transport. The graphene/Al2O3 composite (G‐Al2O3) contains an interconnected macroporous graphene framework with an extremely low sheet electrical resistance down to 0.11 Ω sq−1 and thermal conductivity with 8.28 W m−1 K−1. The G‐Al2O3 provides enormous conductive pathways for electronic and heat transfer, suitable for application as heat sinks. Such a porous composite is also attractive as a highly thermally conductive reservoir to hold phase change materials (stearic acid) for thermal energy storage. This work displays the great potential of CVD direct growth of graphene on dielectric porous substrates for thermal conduction and electronic applications.
A novel architecture of 3D graphene is proposed by direct growth on porous Al2O3 ceramics by using chemical vapor deposition. The graphene/Al2O3 composite provides enormous conductive pathways for electron and phonon transport, suitable for application as a heat sink. Furthermore, the composite acts as a new type of highly thermally conductive reservoir to accommodate phase change materials for thermal energy storage.
Extraordinary tubular graphene cellular material of a tetrahedrally connected covalent structure was very recently discovered as a new supermaterial with ultralight, ultrastiff, superelastic, and ...excellent conductive characteristics, but no high specific surface area will keep it from any next-generation energy storage applications. Herein, we prepare another new graphene monolith of mesoporous graphene-filled tubes instead of hollow tubes in the reported cellular structure. This graphene nanoporous monolith is also composed of covalently bonded carbon network possessing high specific surface area of ∼1590 m2 g–1 and electrical conductivity of ∼32 S cm–1, superior to graphene aerogels and porous graphene forms self-assembled by graphene oxide. This 3D graphene monolith can support over 10 000 times its own weight, significantly superior to CNT and graphene cellular materials with a similar density. Furthermore, pseudocapacitance-active functional groups are introduced into the new nanoporous graphene monolith as an electrode material in electrochemical capacitors. Surprisingly, the electrode of 3D mesoporous graphene has a specific capacitance of 303 F g–1 and maintains over 98% retention after 10 000 cycles, belonging to the list for the best carbon-based active materials. The macroscopic mesoporous graphene monolith suggests the great potential as an electrode for supercapacitors in energy storage areas.
Doxorubicin (DOX) is a highly effective chemotherapeutic drug, but its long-term use can cause cardiotoxicity and drug resistance. Accumulating evidence demonstrates that p53 is directly involved in ...DOX toxicity and resistance. One of the primary causes for DOX resistance is the mutation or inactivation of p53. Moreover, because the non-specific activation of p53 caused by DOX can kill non-cancerous cells, p53 is a popular target for reducing toxicity. However, the reduction in DOX-induced cardiotoxicity (DIC) via p53 suppression is often at odds with the antitumor advantages of p53 reactivation. Therefore, in order to increase the effectiveness of DOX, there is an urgent need to explore p53-targeted anticancer strategies owing to the complex regulatory network and polymorphisms of the p53 gene. In this review, we summarize the role and potential mechanisms of p53 in DIC and resistance. Furthermore, we focus on the advances and challenges in applying dietary nutrients, natural products, and other pharmacological strategies to overcome DOX-induced chemoresistance and cardiotoxicity. Lastly, we present potential therapeutic strategies to address key issues in order to provide new ideas for increasing the clinical use of DOX and improving its anticancer benefits.
In this paper, three-dimensional (3D) graphene network was prepared by chemical vapor deposition (CVD) on 3D porous Ni template. The as-prepared 3D graphene showed high conductivity of similar to 600 ...S cm-1 and low square resistance of 1.6 Omega sq-1. With the aid of 3D graphene network, the poorly conductive LiFePO4 exhibited high conductivity and good rate performance of 109 mA h g-1 at 10 C, indicating potential application in high rate lithium ion batteries.
Distal hereditary motor neuropathy (dHMN) is a heterogeneous group of hereditary diseases caused by the gradual degeneration of the lower motor neuron. More than 30 genes associated with dHMN have ...been reported, while 70-80% of those with the condition are still unable to receive a genetic diagnosis. A 26-year-old man experiencing gradual weakness in his lower limbs was referred to our hospital, and data on clinical features, laboratory tests, and electrophysiological tests were collected. To identify the disease-causing mutation, we conducted whole exome sequencing (WES) and then validated it through Sanger sequencing for the proband and his parents. Silico analysis was performed to predict the pathogenesis of the identified mutations. A literature review of all reported mutations of the related gene for the disease was performed. The patient presented with dHMN phenotype harboring a novel homozygous variant c.361G > C (p.Ala121Pro) in SORD, inherited from his parents, respectively. A121 is a highly conserved site and the mutation was categorized as "likely pathogenic" according to the criteria and guidelines of the American College of Medical Genetics and Genomics (ACMG). A total of 13 published articles including 101 patients reported 18 SORD variants. Almost all described cases have the homozygous deletion variant c.757delG (p.A253Qfs*27) or compound heterozygous state of a combination of c.757delG (p.A253Qfs*27) with another variant. The variant c.361G > C (p.Ala121Pro) detected in our patient was the second homozygous variant in SORD-associated hereditary neuropathy. One novel homozygous variant c.361G > C (p.Ala121Pro) in SORD was identified in a Chinese patient with dHMN phenotype, which expands the mutation spectrum of SORD-associated hereditary neuropathy and underscores the significance of screening for SORD variants in patients with undiagnosed hereditary neuropathy patients.
Quercetin is a natural flavonoid widely found in natural fruits and vegetables. Recent studies have shown that quercetin mediates multiple beneficial effects in a variety of organ damage and ...diseases, and is considered a healthcare supplement with health-promoting potential. Male infertility is a major health concern, and testicular damage from multiple causes is an important etiology. Previous studies have shown that quercetin has a protective effect on reproductive function. This may be related to the antioxidant, anti-inflammatory, and anti-apoptotic biological activities of quercetin. Therefore, this paper reviews the mechanisms by which quercetin exerts its pharmacological activity and its role in testicular damage induced by various etiologies. In addition, this paper compiles the application of quercetin in clinical trials, demonstrating its practical effects in regulating blood pressure and inhibiting cellular senescence in human patients. However, more in-depth experimental studies and clinical trials are needed to confirm the true value of quercetin for the prevention and protection against testicular injury.
In this paper, we report a low-temperature solution method to deposit thio-LISICON, Li3.25Ge0.25P0.75S4, thin film. The low-temperature solution-processed Li3.25Ge0.25P0.75S4 film shows a lithium-ion ...conductivity of 1.82 × 10−4 S cm−1 at 30 °C, an activation energy of 0.42 eV, and a lithium-ion transference number of >0.999, which might be applicable in thin film all solid state lithium-ion batteries.
► A low-temperature solution process has been developed to deposit Li3.25Ge0.25P0.75S4 thin film. ► The Li3.25Ge0.25P0.75S4 thin film has a lithium-ion conductivity of 1.82 × 10−4 S cm−1 at 30 °C. ► The Li3.25Ge0.25P0.75S4 thin film has a lithium-ion transference number of >0.999.
Large current‐driven alkaline water splitting for large‐scale hydrogen production generally suffers from the sluggish charge transfer kinetics. Commercial noble‐metal catalysts are unstable in ...large‐current operation, while most non‐noble metal catalysts can only achieve high activity at low current densities <200 mA cm−2, far lower than industrially‐required current densities (>500 mA cm−2). Herein, a sulfide‐based metallic heterostructure is designed to meet the industrial demand by regulating the electronic structure of phase transition coupling with interfacial defects from Mo and Ni incorporation. The modulation of metallic Mo2S3 and in situ epitaxial growth of bifunctional Ni‐based catalyst to construct metallic heterostructure can facilitate the charge transfer for fast Volmer H and Heyrovsky H2 generation. The Mo2S3@NiMo3S4 electrolyzer requires an ultralow voltage of 1.672 V at a large current density of 1000 mA cm−2, with ≈100% retention over 100 h, outperforming the commercial RuO2||Pt/C, owing to the synergistic effect of the phase and interface electronic modulation. This work sheds light on the design of metallic heterostructure with an optimized interfacial electronic structure and abundant active sites for industrial water splitting.
A metallic heterostructure Mo2S3@NiMo3S4 with enhanced electron transfer properties, fast reaction dynamics, and superior structural stability is designed and fabricated for large‐current alkaline water electrolysis. The constructed water electrolyzer operates at an ultralow cell voltage of 1.672 V@1000 mA cm−2 with ≈100% current density retention over 100 h, superior to the performance of commercial Pt/C║RuO2.
