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  • Convergent Multi-miRNA Targ... Convergent Multi-miRNA Targeting of ApoE Drives LRP1/LRP8-Dependent Melanoma Metastasis and Angiogenesis
    Pencheva, Nora; Tran, Hien; Buss, Colin ... Cell, 11/2012, Volume: 151, Issue: 5
    Journal Article
    Peer reviewed
    Open access

    Through in vivo selection of human cancer cell populations, we uncover a convergent and cooperative miRNA network that drives melanoma metastasis. We identify miR-1908, miR-199a-5p, and miR-199a-3p ...
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  • Control of metastatic progr... Control of metastatic progression by microRNA regulatory networks
    Pencheva, Nora; Tavazoie, Sohail F Nature cell biology, 06/2013, Volume: 15, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    Aberrant microRNA (miRNA) expression is a defining feature of human malignancy. Specific miRNAs have been identified as promoters or suppressors of metastatic progression. miRNAs control metastasis ...
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  • HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events
    Alarcón, Claudio R; Goodarzi, Hani; Lee, Hyeseung ... Cell, 2015-Sep-10, 20150910, Volume: 162, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    N(6)-methyladenosine (m(6)A) is the most abundant internal modification of messenger RNA. While the presence of m(6)A on transcripts can impact nuclear RNA fates, a reader of this mark that mediates ...
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  • LXR/ApoE Activation Restric... LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer
    Tavazoie, Masoud F.; Pollack, Ilana; Tanqueco, Raissa ... Cell, 02/2018, Volume: 172, Issue: 4
    Journal Article
    Peer reviewed
    Open access

    Therapeutic harnessing of adaptive immunity via checkpoint inhibition has transformed the treatment of many cancers. Despite unprecedented long-term responses, most patients do not respond to these ...
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  • Endogenous tRNA-Derived Fra... Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement
    Goodarzi, Hani; Liu, Xuhang; Nguyen, Hoang C.B. ... Cell, 05/2015, Volume: 161, Issue: 4
    Journal Article
    Peer reviewed
    Open access

    Upon exposure to stress, tRNAs are enzymatically cleaved, yielding distinct classes of tRNA-derived fragments (tRFs). We identify a novel class of tRFs derived from tRNAGlu, tRNAAsp, tRNAGly, and ...
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  • PITPNC1 Recruits RAB1B to t... PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion
    Halberg, Nils; Sengelaub, Caitlin A.; Navrazhina, Kristina ... Cancer cell, 03/2016, Volume: 29, Issue: 3
    Journal Article
    Peer reviewed
    Open access

    Enhanced secretion of tumorigenic effector proteins is a feature of malignant cells. The molecular mechanisms underlying this feature are poorly defined. We identify PITPNC1 as a gene amplified in a ...
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  • Broad-Spectrum Therapeutic ... Broad-Spectrum Therapeutic Suppression of Metastatic Melanoma through Nuclear Hormone Receptor Activation
    Pencheva, Nora; Buss, Colin G.; Posada, Jessica ... Cell, 02/2014, Volume: 156, Issue: 5
    Journal Article
    Peer reviewed
    Open access

    Melanoma metastasis is a devastating outcome lacking an effective preventative therapeutic. We provide pharmacologic, molecular, and genetic evidence establishing the liver-X nuclear hormone receptor ...
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  • Modulated Expression of Spe... Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression
    Goodarzi, Hani; Nguyen, Hoang C.B.; Zhang, Steven ... Cell, 06/2016, Volume: 165, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    Transfer RNAs (tRNAs) are primarily viewed as static contributors to gene expression. By developing a high-throughput tRNA profiling method, we find that specific tRNAs are upregulated in human ...
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  • A microRNA regulon that med... A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells
    Png, Kim J; Halberg, Nils; Yoshida, Mitsukuni ... Nature (London), 01/2012, Volume: 481, Issue: 7380
    Journal Article
    Peer reviewed

    Metastatic progression of cancer is a complex and clinically daunting process. We previously identified a set of human microRNAs (miRNAs) that robustly suppress breast cancer metastasis to lung and ...
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