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  • SPRTN is a mammalian DNA-bi... SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks
    Lopez-Mosqueda, Jaime; Maddi, Karthik; Prgomet, Stefan ... eLife, 11/2016, Volume: 5
    Journal Article
    Peer reviewed
    Open access

    Ruijs-Aalfs syndrome is a segmental progeroid syndrome resulting from mutations in the gene. Cells derived from patients with SPRTN mutations elicit genomic instability and people afflicted with this ...
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  • Ubiquitin-independent funct... Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates
    Korac, Jelena; Schaeffer, Veronique; Kovacevic, Igor ... Journal of cell science, 01/2013, Volume: 126, Issue: Pt 2
    Journal Article
    Peer reviewed
    Open access

    Aggregation of misfolded proteins and the associated loss of neurons are considered a hallmark of numerous neurodegenerative diseases. Optineurin is present in protein inclusions observed in various ...
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  • IL-6 and Stat3 Are Required... IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer
    Grivennikov, Sergei; Karin, Eliad; Terzic, Janos ... Cancer cell, 02/2009, Volume: 15, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    Colitis-associated cancer (CAC) is the most serious complication of inflammatory bowel disease. Proinflammatory cytokines have been suggested to regulate preneoplastic growth during CAC ...
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  • The urinary microbiome asso... The urinary microbiome associated with bladder cancer
    Bučević Popović, Viljemka; Šitum, Marijan; Chow, Cheryl-Emiliane T ... Scientific reports, 08/2018, Volume: 8, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Recent findings suggest that human microbiome can influence the development of cancer, but the role of microorganisms in bladder cancer pathogenesis has not been explored yet. The aim of this study ...
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  • Nix is a selective autophag... Nix is a selective autophagy receptor for mitochondrial clearance
    Novak, Ivana; Kirkin, Vladimir; McEwan, David G ... EMBO reports, January 2010, Volume: 11, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Autophagy is the cellular homeostatic pathway that delivers large cytosolic materials for degradation in the lysosome. Recent evidence indicates that autophagy mediates selective removal of protein ...
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  • Mutations in SPRTN cause ea... Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features
    Lessel, Davor; Vaz, Bruno; Halder, Swagata ... Nature genetics, 11/2014, Volume: 46, Issue: 11
    Journal Article
    Peer reviewed
    Open access

    Age-related degenerative and malignant diseases represent major challenges for health care systems. Elucidation of the molecular mechanisms underlying carcinogenesis and age-associated pathologies is ...
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  • Targeting Stat3 signaling i... Targeting Stat3 signaling impairs the progression of bladder cancer in a mouse model
    Korac-Prlic, Jelena; Degoricija, Marina; Vilović, Katarina ... Cancer letters, 10/2020, Volume: 490
    Journal Article
    Peer reviewed

    Bladder cancer is the fourth most commonly diagnosed malignancy in men worldwide and has one of the highest recurrence rates of all cancers. This cancer type is unique because chronic inflammation ...
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  • Inflammation and Colon Cancer Inflammation and Colon Cancer
    Terzić, Janoš; Grivennikov, Sergei; Karin, Eliad ... Gastroenterology, 06/2010, Volume: 138, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    The connection between inflammation and tumorigenesis is well-established and in the last decade has received a great deal of supporting evidence from genetic, pharmacological, and epidemiological ...
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  • MyD88 Signaling Accompanied... MyD88 Signaling Accompanied by Microbiota Changes Supports Urinary Bladder Carcinogenesis
    Knezović, Dora; Milić Roje, Blanka; Vilović, Katarina ... International journal of molecular sciences, 07/2024, Volume: 25, Issue: 13
    Journal Article
    Peer reviewed
    Open access

    Urinary bladder cancer (BC) inflicts a significant impairment of life quality and poses a high mortality risk. Schistosoma haematobium infection can cause BC, and the urinary microbiota of BC ...
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  • Activation of cGAS-STING Pa... Activation of cGAS-STING Pathway Is Associated with MSI-H Stage IV Colorectal Cancer
    Kunac, Nenad; Degoricija, Marina; Viculin, Jelena ... Cancers, 12/2022, Volume: 15, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Colorectal cancer is the second most common cause of cancer-related mortality in adults. Understanding colorectal tumorigenesis at both the cellular and molecular levels is crucial for developing ...
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