Abstract
Nuclear nanomedicine, with its targeting ability and heavily loading capacity, along with its enhanced retention to avoid rapid clearance as faced with molecular radiopharmaceuticals, ...provides unique opportunities to treat tumors and metastasis. Despite these promises, this field has seen limited activities, primarily because of a lack of suitable nanocarriers, which are safe, excretable and have favorable pharmacokinetics to efficiently deliver and retain radionuclides in a tumor. Here, we introduce biodegradable laser-synthesized Si nanoparticles having round shape, controllable low-dispersion size, and being free of any toxic impurities, as highly suitable carriers of therapeutic
188
Re radionuclide. The conjugation of the polyethylene glycol-coated Si nanoparticles with radioactive
188
Re takes merely 1 hour, compared to its half-life of 17 hours. When intravenously administered in a Wistar rat model, the conjugates demonstrate free circulation in the blood stream to reach all organs and target tumors, which is radically in contrast with that of the
188
Re salt that mostly accumulates in the thyroid gland. We also show that the nanoparticles ensure excellent retention of
188
Re in tumor, not possible with the salt, which enables one to maximize the therapeutic effect, as well as exhibit a complete time-delayed conjugate bioelimination. Finally, our tests on rat survival demonstrate excellent therapeutic effect (72% survival compared to 0% of the control group). Combined with a series of imaging and therapeutic functionalities based on unique intrinsic properties of Si nanoparticles, the proposed biodegradable complex promises a major advancement in nuclear nanomedicine.
A method for reinforcing a compound based on styrene-butadiene thermoplastic elastomer has been developed. The mechanical characteristics of reinforced compounds have been studied. A comparative ...analysis of various methods for introducing a nanofiller into a polymer matrix has been carried out. The developed technique shows an increase in the compressive strength of the composition by 50%, as well as tensile strength by 20%.
The process
e
+
e
-
→
η
η
γ
is studied in the center-of-mass energy range 1.17–2.00 GeV using data with an integrated luminosity of 201 pb
-
1
collected by the SND detector at the VEPP-2000
e
+
e
-
...collider. The
e
+
e
-
→
η
η
γ
cross section is measured for the first time. It is shown that the dominant mechanism of this reaction is the transition through the
ϕ
η
intermediate state. Our result on the
e
+
e
-
→
η
η
γ
cross section is consistent with the
e
+
e
-
→
ϕ
η
measurement in the
ϕ
→
K
+
K
-
mode. The search for radiative processes contributing to the
e
+
e
-
→
η
η
γ
cross section is performed, and no significant signal is observed.
The cross section of the process e + e − → π + π − has been measured in the center of mass energy range from 0.32 to 1.2 GeV with the CMD-3 detector at the electron-positron collider VEPP-2000. The ...measurement is based on a full dataset collected below 1 GeV during three data taking seasons, corresponding to an integrated luminosity of about 62 pb − 1 . In the dominant ρ -resonance region, a systematic uncertainty of 0.7% has been reached. At energies around ϕ -resonance the π + π − production cross section was measured for the first time with high beam energy resolution. The forward-backward charge asymmetry in the π + π − production has also been measured. It shows a strong deviation from the theoretical prediction based on the conventional scalar quantum electrodynamics framework, and it is in good agreement with the generalized vector-meson-dominance and dispersive-based predictions. The impact of the presented results on the evaluation of the hadronic contribution to the anomalous magnetic moment of muon is discussed. Published by the American Physical Society 2024
A new thermoplastic elastomer based on styrene-butadiene rubber and polypropylene for 3D printing using FDM (Fused Deposition Modeling) technology is obtained and studied. The physical and mechanical ...characteristics of products made of a new material with high strength and elasticity at the same time are studied. The developed material will find application in the automotive industry, civil shipbuilding, aerospace engineering, shock-absorbing systems for railway transport, and other areas.
Thermoplastic elastomers (TPEs) reinforced with detonation nanodiamonds (DNDs) based on styrene-butadiene rubber are developed. The mechanical characteristics of the reinforced compounds with ...different DND contents are investigated. The developed material shows a 30% increase in compressive strength compared to the unfilled composite and a 10% increase in the tensile strength of the material with the introduction of 0.1% DND.
Thermoplastic elastomer based on styrene-butadiene rubber was developed for 3D printing using fused deposition modelling. 3D modeling of simple and complex geometric structures from the developed ...material is performed. Optimal 3D printing parameters for this material were obtained.
The
cross section is measured in the center-of-mass energy range from 1.07 to 2.00 GeV in the decay channel
,
. The data set with an integrated luminosity of 242 pb
accumulated in the experiment with ...the SND detector at the VEPP-2000
collider is analyzed.
—
Thermoplastic elastomer based on butadiene–styrene rubber has been developed for 3D printing using fused deposition modeling (FDM). The influence of the intensity of the flow and the direction of ...printing on the physical and mechanical characteristics of the material was investigated. A comparative analysis of 3D printed products and products made by thermal pressing was carried out. The developed material shows an increase in strength during manufacture using fused deposition modeling by 18% compared to the molded sample, as well as an increase in strength by 25% and elongation by 50% with increased print intensity.
Recent Progress in the VEPP-2000 Collider Rastigeev, S. A.; Aktershev, Yu. S.; Bedarev, E. V. ...
Physics of particles and nuclei letters,
08/2023, Volume:
20, Issue:
4
Journal Article
Peer reviewed
The VEPP-2000 is an electron–positron collider with round beams built and operating at the Budker Institute of Nuclear Physics (BINP). The collider luminosity was increased twofold last year. The ...integrated luminosity accumulated over the last year has exceeded 0.3 fb
–1
, which almost doubled the total data collected since the collider operation began. The short description of the VEPP-2000 complex, current status, and the results are presented in this work.
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