To evaluate the clinical value of the expression of multidrug resistance P-glycoprotein (P-170) on the surface of acute nonlymphoblastic leukemia (ANLL) cells, we analyzed specimens from 150 newly ...diagnosed patients for staining with MRK16, a monoclonal antibody (MoAb) that binds to an external epitope of P-170. Other surface markers (CD13, CD14, CD15, and CD34) were studied by the same technique. A marker was considered positive when 20% or more cells were stained. Of 150 samples, 71 were P-170-positive. These cases did not differ from P-170-negative cases with regard to age, sex, initial white blood cell (WBC) counts, or French-American-British (FAB) type (except for M3 ANLL, which were more frequently negative). However, leukemias arising from previous myelodysplastic syndrome (MDS) and therapy- induced leukemias were more frequently P-170-positive. CD34 and P-170 expression were significantly associated. All patients were treated by intensive chemotherapy. Complete remission (CR) rates were significantly lower in P-170-positive (23/71, 32%) than in P-170-negative cases (64/79, 81%) P < 10 -5). CD34 positivity was also associated with a low remission rate P < 10 -s). Survival was shorter for P-170-and CD34-positive patients P < 10 -5). The prognostic value of both markers was confirmed in multivariate analysis. CR duration was also shorter for P-170-positive cases, but the difference is less significant (P =.05). It is concluded that P-170 analysis may be an important tool for predicting the outcome of intensive chemotherapy in ANLL patients.
The physics potential of the RICH Treille, D
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
03/1996, Volume:
371, Issue:
1
Journal Article
Peer reviewed
An overview of the physics potential of the RICH technique in present and future programmes is given.
Searches at LEP Treille, Daniel
Physics reports,
12/2004, Volume:
403-404
Journal Article
Peer reviewed
Twelve years of searches at LEP1 and especially LEP2 are summarized. Indirect searches, resulting from the accurate measurements of electroweak observables, are reviewed and the conclusions ...concerning the Higgs boson are recalled. Direct searches for this boson as well as for non-standard effects and particles are described. We quote the limits which have been set on their existence. we analyse the impact of all these results on the various models proposed to extend the Standard Model, in particular Supersymmetry, Compositeness and Extra-dimensions.
I will review some of the challenges set by the LHC machine, the LHC detectors and the extraction of LHC physics. I will also consider briefly another question: which road should one follow after the ...first phase of LHC?
An analysis of the direct soft photon production rate as a function of the parent jet characteristics is presented, based on hadronic events collected by the DELPHI experiment at LEP1. The ...dependences of the photon rates on the jet kinematic characteristics (momentum, mass, etc.) and on the jet charged, neutral and total hadron multiplicities are reported. Up to a scale factor of about four, which characterizes the overall value of the soft photon excess, a similarity of the observed soft photon behavior to that of the inner hadronic bremsstrahlung predictions is found for the momentum, mass, and jet charged multiplicity dependences. However for the dependence of the soft photon rate on the jet neutral and total hadron multiplicities a prominent difference is found for the observed soft photon signal as compared to the expected bremsstrahlung from final state hadrons. The observed linear increase of the soft photon production rate with the jet total hadron multiplicity and its strong dependence on the jet neutral multiplicity suggest that the rate is proportional to the number of quark pairs produced in the fragmentation process, with the neutral pairs being more effectively radiating than the charged ones.
A measurement of the W boson mass and width has been performed by the DELPHI collaboration using the data collected during the full LEP2 programme (1996-2000). The data sample has an integrated ...luminosity of 660 pb(-1) and was collected over a range of centre-of-mass energies from 161 to 209 GeV. Results are obtained by applying the method of direct reconstruction of the mass of the W from its decay products in both the W+W- -> l (nu) over bar (l) and W+W- -> q (q) over bar'(q) over barq'channels. The W mass result for the combined data set is M-W = 80.336 +/- 0.055(Stat.) +/- 0.028(Syst.) +/- 0.025(FSI) +/- 0.009(LEP) GeV/c(2) , where FSI represents the uncertainty due to final state interaction effects in the q (q) over bar'(q) over barq' channel, and LEP represents that arising from the knowledge of the collision energy of the accelerator. The combined value for the W width is Gamma(W) = 2.404 +/- 0.140(Stat.) +/- 0.077(Syst.) +/- 0.065(FSI) GeV/c(2). These results supersede all values previously published by the DELPHI collaboration.
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