A selected sample of 492 strains of
Streptococcus pneumoniae (175 susceptible, 142 intermediately resistant, and 175 highly resistant to penicillin) isolated from adult patients in Bellvitge ...Hospital, Barcelona, Spain, was tested for susceptibility to 16 antibiotics using a microdilution broth method. Imipenen, rifampin, vancomycin, cefpirome, cefotaxime, and amoxicillin were the most active antibiotics against penicillin-resistant pneumococci. The strains with intermediate or high resistance to penicillin exhibited a significantly greater percentage of resistance (
P ⩽ 0.05) to erythromycin, clindamycin, tetracycline, chloramphenicol, and cotrimoxazole than penicillin-susceptible pneumococci. No resistance to third-generation cephalosporins was detected among penicillin-susceptible strains, whereas 1.4% of intermediately resistant strains and 13.2% of penicillin-resistant strains showed minimal inhibitory concentrations of cefotaxime ⩾ 2 μg/mL.
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