The ring rearrangement metathesis (RRM) of a
-
diastereomer mixture of methyl 3-allyl-3a,6-epoxyisoindole-7-carboxylates derived from cheap, accessible and renewable furan-based precursors in the ...presence of a new class of Hoveyda-Grubbs-type catalysts, comprising an N→Ru coordinate bond in a six-membered ring, results in the difficult-to-obtain natural product-like cyclopenta
furo2,3-
pyrroles. In this process, only one diastereomer with a
-arrangement of the 3-allyl fragment relative to the 3a,6-epoxy bridge enters into the rearrangement, while the
-isomers polymerize almost completely under the same conditions. The tested catalysts are active in the temperature range from 60 to 120 °C at a concentration of 0.5 mol % and provide better yields of the target tricycles compared to the most popular commercially available second-generation Hoveyda-Grubbs catalyst. The diastereoselectivity of the intramolecular Diels-Alder reaction furan (IMDAF) reaction between starting 1-(furan-2-yl)but-3-en-1-amines and maleic anhydride, leading to 3a,6-epoxyisoindole-7-carboxylates, was studied as well.
The development of permafrost areas requires reliable and long-term projected estimates in a changing climate and man-made impacts. Dangerous natural and man-made factors, such as snowfall, ...infiltration of precipitation, ice, thermokarst, etc., interact with the ground and determine the stability of the territories of the cryolithozone. In this regard, the work is devoted to the development of new algorithms and software for identifying the boundary conditions on the surface of frozen soil, taking into account the actual process of freezing and thawing of the pore solution of the soil.
—The morphotypic variability of the anteroconid shape of the first lower molar of fossil and modern (continental and insular) populations of the reed vole (
Alexandromys fortis
) from the territory ...of Primorye (the south of the Russian Far East) has been analyzed. The morphotypic variability is considered based on the study of variations in the structure of the labial and lingual sides of the anterior unpaired loop and structural features of the lingual reentrant angle 4. Thirty-six morphotypes of the structure of the unpaired anterior loop of anteroconid m1 have been revealed using the developed combinatory matrix. The most widespread morphotype on the continent is IIICa, which prevailed in the Late Pleistocene. The features of the morphotypic composition of m1 in the differentiated populations of the reed vole on the Durnovo, De-Livron, and Vera islands (Peter the Great Bay) are determined both by the phenotypic and genotypic characteristics of the founders of the insular populations. The original new habitat conditions must have initiated a high rate of evolution, released hidden diversity, and increased the number of rare morphotypes.
The current paper first time describes a small Beremendia from the late Pleistocene deposits in the Koridornaya Cave locality (Russian Far East), which associated with the extinct Beremendia minor. ...The paper is the first attempt to use a comparative analytical method to evaluate a possible case of redeposition of fossil remains of this shrew. In this case, the 'comparative' part of the method corresponds to the 'faunistic approach' of Jelle Reumer, and the 'analytical' part of the method corresponds to his extended 'morphological approach. ' The analytic method uses morphospace size estimation (MSE) based on principal component analysis and estimation of the variance to evaluate redeposition of Beremendia minor from the late Pleistocene deposits in the Koridornaya Cave. This result allows us to suggest the significant environmental contribution to the East Asian beremendiin extinction, such as climatic fluctuation, landscape changes and shrew community changes between the late Pliocene and early Pleistocene. We discuss the last remains of East Asian Beremendia (Peisorex) described from the Chinese early Pleistocene localities (Chiachiashan, Haimao, Renzidong) and the last remains of Lunanosorex described from the Chinese late Pliocene localities (Qipanshan Hill and Houxushan Hill). MSE was performed for soricine tribes with the 'elongated' condylar process.
Background. Abnormal uterine bleeding (AUB) occurs in one-third of women of reproductive age and has a significant impact on women's lives, causing anemia, impaired social adaptation and professional ...activity.
AUB-O (ovulatory dysfunction) is often caused by an excessive body mass (BM) and obesity (especially visceral). The most effective option for restoring menstrual cycle (MC) in obese women is BM reduction. There is evidence that the combination of inositols myoinositol (MI) and D-chiroinositol (DCI) has a beneficial effect on BM loss, ovulation frequency and getting pregnant in women with polycystic ovary syndrome.
Aim. To study the effect of MI and DHI in a 5:1 ratio in combination with diet and exercise on the regulation of MC in overweight and obese women.
Materials and methods. The study has been conducted in clinics of Moscow, Kazan and Tyumen for 20202021. It is a descriptive study assessing an efficacy of lifestyle modification (diet and exercise) plus a nutritional support with a combination of 1000 mg MI and 200 mg DCI (ratio 5:1) for 24 months in 353 women of reproductive age with AMK-O and overweight or obesity. Efficacy criteria include: MC regularity, BM index (BMI), waist circumference (WC), levels of serum glucose, free testosterone, follicle-stimulating hormone, luteinizing hormone.
Results. The study showed a significant shortening of MC to its physiological duration 3112.04 days (vs 4419.51 days at the 1st visit; p=0.001), a decrease in the rate of heavy bloody vaginal discharge by 2.57 times (p=0.001), an increase in the rate of moderate bloody vaginal discharge by 1,62 times (p=0.001), an increase in the proportion of patients with regular MC by 2.69 times (p=0.001). These changes were accompanied by a decrease in BM (-3 kg; p=0.001), a decrease in WC (-2.5 cm; p=0.001). Laboratory tests revealed a decrease in serum glucose (-1.3 mmol/L; p0.05), free testosterone (-0.4 pg/L; p0.05), luteinizing hormone (-0.8 mIU/ml; p0.05), and an increase in follicle-stimulating hormone (+0.1 mIU/ml; p0.05) levels.
Conclusion. The results obtained (a decrease in BM, a decrease in BMI, WC, as well as MC restoration; p0.05) make it possible to recommend Dikirogen containing MI and DCI in a 5:1 ratio as a part of comprehensive therapy for overweight and obese women with AUB-O.
Electromagnetic calorimeter for Belle II Belle-ECL; Aulchenko, V; Bobrov, A ...
Journal of physics. Conference series,
01/2015, Volume:
587, Issue:
1
Journal Article
Peer reviewed
Open access
The electromagnetic calorimeter of the BELLE II detector for experiments at Super B-factory SuperKEKB is briefly described. The project of the calorimeter upgrade to meet severe background conditions ...expected at the upgraded KEK B factory is presented.
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