Etiology of otitis media with effusion (OME) is still unclear and often described as multi-factorial. It is very usual finding in cleft palate population. We tested relationship between the hearing ...level, audiometric frequencies, aging and ear side in unilateral cleft lip and palate 101 children (UCLP) and subgroups of left (UCLP)(L) and right cleft side (UCLP)(R). Group of left ears is prone to higher frequency and more severe hearing disturbances than groups of right ears, with less chance of normalizing hearing level with aging. Characteristics of hearing loss level and its improvement, in UCLP children depend of cleft type, ear side and age group.
The aim of this study is to test the possible prognostic significance of p53 and Ki67 expression in inverted papilloma of the lateral nasal wall and adjacent sinuses regarding their malignant ...potential and recurrence. 49 biopsies of the lateral nasal wall and adjacent sinuses obtained from 41 patients from three hospitals were investigated. Immunohistochemically demonstrated p53 and Ki67 expression was measured and statistically evaluated. p53 immunoreactivity was demonstrated in most of papillomas with carcinomas but only in two benign papillomas, while Ki67 demonstrated stronger immunoreactivity in carcinomas and surrounding epithelium. Immunohistochemical staining of inverted sinonasal papillomas for p53 and Ki67 can give useful information concerning the existence of synchronous carcinoma and, in case of high Ki67, a hint toward possible recurrence.
Inverted papilloma is an epithelial neoplasm of the lateral nasal wall and adjacent sinuses characterized by a marked propensity for recurrence and a significant association with carcinoma. In this ...retrospective study we present 31 cases treated by our departments between 1982 and 1999. The aim was to compare our results to those of other authors especially regarding surgical management. The male to female ratio of these patients was 2:1 and most patients were in the 6th and 7th decades of life. Conservative surgery was used in most cases as the initial treatment. The overall recurrence rate was low and there were 3 cases associated with carcinoma. We conclude that the results of conservative surgery in selected cases are comparable to those using radical methods. A review of the literature is presented and particular attention is dedicated to the literature concerning analysis of p53 expression, HPV and Epstein-Barr infection and apoptosis in inverted papilloma.
Etiology of otitis media with effusion (OME) is still unclear and often described as multi-factorial. It is very usual finding in cleft palate population. We tested relationship between the hearing ...level, audiometric frequencies, aging and ear side in unilateral cleft lip and palate 101 children (UCLP) and subgroups of left (UCLP)(L) and right cleft side (UCLP)(R). Group of left ears is prone to higher frequency and more severe hearing disturbances than groups of right ears, with less chance of normalizing hearing level with aging. Characteristics of hearing loss level and its improvement, in UCLP children depend of cleft type, ear side and age group.
The aim of this study is to test the possible prognostic significance of p53 and Ki67 expression in inverted papilloma
of the lateral nasal wall and adjacent sinuses regarding their malignant ...potential and recurrence. 49 biopsies of the lateral
nasal wall and adjacent sinuses obtained from 41 patients from three hospitals were investigated. Immunohistochemically
demonstrated p53 and Ki67 expression was measured and statistically valuated. p53 immunoreactivity
was demonstrated in most of papillomas with carcinomas but only in two benign papillomas, while Ki67 demonstrated
stronger immunoreactivity in carcinomas and surrounding epithelium. Immunohistochemical staining of inverted sinonasal
papillomas for p53 and Ki67 can give useful information concerning the existence of synchronous carcinoma and,
in case of high Ki67, a hint toward possible recurrence.
Inverted papilloma is an epithelial neoplasm of the lateral nasal wall and adjacent
sinuses characterized by a marked propensity for recurrence and a significant association
with carcinoma In this ...retrospective study we present 31 cases treated by our departments
between 1982 and 1999. The aim was to compare our results to those of other
authors especially regarding surgical management. The male to female ratio of these
patients was 2:1 and most patients were in the 6th and 7th decades of life. Conservative
surgery was used in most cases as the initial treatment. The overall recurrence rate was
low and there were 3 cases associated with carcinoma. We conclude that the results of
conservative surgery in selected cases are comparable to those using radical methods. A
review of the literature is presented and particular attention is dedicated to the literature
concerning analysis of p53 expression, HPV and Epstein-Barr infection and apoptosis
in inverted papilloma.
