A great deal of research has focused on supply chain risk management, but the question “Which supply chain characteristics increase the frequency of supply chain disruptions?” has not received much ...attention from empirical research. This is a relevant question, because firms seek stability in their operations, and therefore managers need to know how the structure of their supply chains affects the occurrence of disruptions. The present study addresses this issue with a specific focus on upstream supply chain (supply-side) disruptions. Drawing on the literature on supply chain complexity, we devise and test a model that predicts the frequency of supply chain disruptions based on a multi-dimensional conceptualization of upstream supply chain complexity. Not only do the empirical findings suggest that all of the three investigated complexity drivers – horizontal, vertical, and spatial complexity – increase the frequency of disruptions, but also that they interact and amplify each other's effects in a synergistic fashion.
The vast majority of the supplier innovation literature has focused on how buying firms can effectively “pull” innovations from their suppliers. Yet, we know remarkably little about the factors that ...contribute to a supplier voluntarily “pushing” innovations to its customers. The present study addresses this research gap in the context of industrial buyer–supplier relationships and with a specific focus on relationship-specific investments. Drawing on theory from the relationship-marketing literature and on transaction cost theory, we devise and test a proposed theoretical model that links the level of a supplier's relationship-specific investments to its sharing of innovative ideas regarding products and processes with customers. The model also considers the role of contract length, relationship age, and buyer–supplier cooperation as possible safeguards. The empirical results suggest that a supplier's relationship-specific investments encourage a supplier to suggest ideas of process innovations but to refrain from suggestions about product innovations. The latter effect, however, can be attenuated by appropriate formal and informal safeguards.
Summary
CD26/DPP4 (dipeptidyl peptidase 4/DP4/DPPIV) is a surface T cell activation antigen and has been shown to have DPP4 enzymatic activity, cleaving‐off amino‐terminal dipeptides with either ...L‐proline or L‐alanine at the penultimate position. It plays a major role in glucose metabolism by N‐terminal truncation and inactivation of the incretins glucagon‐like peptide‐1 (GLP) and gastric inhibitory protein (GIP). In 2006, DPP4 inhibitors have been introduced to clinics and have been demonstrated to efficiently enhance the endogenous insulin secretion via prolongation of the half‐life of GLP‐1 and GIP in patients. However, a large number of studies demonstrate clearly that CD26/DPP4 also plays an integral role in the immune system, particularly in T cell activation. Therefore, inhibition of DPP4 might represent a double‐edged sword. Apart from the metabolic benefit, the associated immunological effects of long term DPP4 inhibition on regulatory processes such as T cell homeostasis, maturation and activation are not understood fully at this stage. The current data point to an important role for CD26/DPP4 in maintaining lymphocyte composition and function, T cell activation and co‐stimulation, memory T cell generation and thymic emigration patterns during immune‐senescence. In rodents, critical immune changes occur at baseline levels as well as after in‐vitro and in‐vivo challenge. In patients receiving DPP4 inhibitors, evidence of immunological side effects also became apparent. The scope of this review is to recapitulate the role of CD26/DPP4 in the immune system regarding its pharmacological inhibition and T cell‐dependent immune regulation.
PurposeStartups are associated with innovation, emerging technologies, digitalization and disruptive business models. This article aims to provide a better understanding of startups in logistics and ...supply chain management, organizes the contemporary discussion around startups in the supply chain ecosystem and outlines opportunities for future research.Design/methodology/approachThis study draws on the prior supply chain, logistics and entrepreneurship literature and discusses key themes along the six identified startup issues. Furthermore, it proposes several perspectives and theories for grounding future research.FindingsThis study discusses the roles and success factors of startups in the supply chain ecosystem. It lays out how startups need to organize their own supply chains, how supply chain management (SCM) startups incubate and accelerate their ventures, the financing of SCM startups, as well as their positions as service providers, suppliers and customers.Originality/valueThis research brings together the sparse and dispersed literature on startups in the supply chain ecosystem, motivating scholars to increase the involvement of startups as important stakeholders in SCM research.
The digitalization of intra‐ and inter‐organizational processes offers significant opportunity for research in the field of operations and supply chain management (OSCM). This essay summarizes the ...contributions of the special issue articles, highlighting their focus on additive manufacturing and the encapsulation of design and production information in a digital artifact. We conceptualize the digital artifact as containing the digital genes of the associated physical object. Digital encapsulation thus involves the integration of product design information with additional information on how that design is to be translated into a physical object, delivered to the customer, and used. Building on insights from the special issue articles, we identify three pathways by which digital encapsulation affects OSCM practice, as well as theory elaboration and extension. First, digital encapsulation allows each unique digitally encapsulated artifact to be acted on independently by OSCM systems. Second, digital encapsulation enables the redistribution of activities across organizational and geographic landscapes. Third, digital encapsulation facilitates interactivity of the digital artifact with external environment inputs. We conclude with a number of directions for future research.
Boundary Conditions Busse, Christian; Kach, Andrew P.; Wagner, Stephan M.
Organizational research methods,
10/2017, Volume:
20, Issue:
4
Journal Article
Peer reviewed
Boundary conditions (BC) have long been discussed as an important element in theory development, referring to the “who, where, when” aspects of a theory. However, it still remains somewhat vague as ...to what exactly BC are, how they can or even should be explored, and why their understanding matters. This research tackles these important questions by means of an in-depth theoretical-methodological analysis. The study contributes fourfold to organizational research methods: First, it develops a more accurate and explicit conceptualization of BC. Second, it widens the understanding of how BC can be explored by suggesting and juxtaposing new tools and approaches. It also illustrates BC-exploring processes, drawing on two empirical case examples. Third, it analyzes the reasons for exploring BC, concluding that BC exploration fosters theory development, strengthens research validity, and mitigates the research-practice gap. Fourth, it synthesizes the analyses into 12 tentative suggestions for how scholars should subsequently approach the issues surrounding BC. The authors hope that the study contributes to consensus shifting with respect to BC and draws more attention to BC.
In today's business environment, harsher and more frequent natural and man-made disasters make supply chains more vulnerable. Supply chain disruptions now seem to occur more frequently and with more ...serious consequences. During and after supply chain disruptions, companies may lose revenue and incur high recovery costs. If supply chain managers were more capable of measuring and managing supply chain vulnerability, they could reduce the number of disruptions and their impact. In this research we developed an approach based on graph theory to quantify and hence mitigate supply chain vulnerability. Quantification of supply chain vulnerability aids managers in assessing the vulnerability of their supply chains (e.g., across and between supply chains, or over time) and in comparing the effectiveness of different risk mitigation strategies.
Blockchain technology is destined to revolutionise supply chain processes. At the same time, governmental and regulatory policies are forcing firms to adjust their supply chains in response to ...environmental concerns. The objective of this study is therefore to develop a distributed ledger-based blockchain approach for monitoring supply chain performance and optimising both emission levels and operational costs in a synchronised fashion, producing a better outcome for the supply chain. We propose the blockchain approach for different production allocation problems within a multi-echelon supply chain (MESC) under a carbon taxation policy. As such, we couple recent advances in digitalisation of operations with increasingly stringent regulatory environmental policies. Specifically, with lead time considerations under emission rate constraints (imposed by a carbon taxation policy), we simultaneously consider the production, distribution and inventory control decisions in a production allocation-based MESC problem. The problem is then formulated as a Mixed Integer Non-Linear Programming (MINLP) model. We show that the distributed ledger-based blockchain approach minimises both total cost and carbon emissions. We then validate the feasibility of the proposed approach by comparing the results with a non-dominated sorting genetic algorithm (NSGA-II). The findings provide support for policymakers and supply chain executives alike.
•We analyze route efficiency trade-offs emerging from combining pickups and deliveries in an urban distribution system.•We extend continuum approximation-based route length estimations by proposing ...adjustment factors for integrated pickup and delivery operations.•Local route efficiency can improve by up to 30%, while being highly sensitive to vehicle capacity and precedence constraints.•We apply our method to a real-world case study to inform the strategic design and operational planning of an urban distribution system.
In this paper, we analyze the route efficiency trade-offs that emerge from combining first-mile pickup and last-mile delivery operations in an urban distribution system. We build on the extant literature on continuum approximation of optimal route distances and propose adjustment factors that account for the effects of integrated pickup and delivery operations. By means of comprehensive numerical experiments and regression analysis, we further propose a set of closed-form adjustment factors that improve existing continuum approximation-based route length estimations. These adjustment factors incorporate some non-trivial route efficiency trade-offs emerging from first-mile and last-mile integration that cannot easily be captured through continuum approximation. The proposed extensions are particularly relevant for the optimal strategic design and operational planning of large-scale, high-density last-mile distribution systems that are gaining in importance in light of e-commerce and omni-channel retailing. Our analyses suggest that the efficiency gains emerging from integrating first-mile pickup and last-mile delivery operations can be as high as 30%. However, the effective efficiency gains are sensitive to vehicle capacity constraints and other factors complicating the optimal stop sequence in integrated routes. We apply our proposed method to a real-world case study informed by operational data from one of India’s largest e-commerce platforms for the city of Bengaluru. We find that by properly integrating its first-mile and last-mile operations, the company could reduce its urban traffic and emissions impact by up to 16%, while increasing the asset utilization and reducing the cost of operations of its vehicle fleet.
Why, how, and under what conditions do firms respond to supply chain disruptions? These are important questions, given that firms around the world are increasingly exposed to disruptions that impede ...their supply chain relationships and associated operations. This study applies information processing and resource dependence perspectives to identify the repertoire of strategic responses to supply chain disruptions and to devise and test a model that explains the occurrence of the alternative responses. The findings suggest that these responses are shaped by the "stability motive" and by "interpretative postures," which evolve from past experiences.
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