Movements result from a complex interplay of multiple brain regions. These regions are assembled into distinct functional networks depending on the specific properties of the action. However, the ...nature and details of the dynamics of this complex assembly process are unknown. In this study, we sought to identify key markers of the neural processes underlying the preparation and execution of motor actions that always occur irrespective of differences in movement initiation, hence the specific neural processes and functional networks involved. To this end, EEG activity was continuously recorded from 18 right-handed healthy participants while they performed a simple motor task consisting of button presses with the left or right index finger. The movement was performed either in response to a visual cue or at a self-chosen, i.e., non-cued point in time. Despite these substantial differences in movement initiation, dynamic properties of the EEG signals common to both conditions could be identified using time–frequency and phase locking analysis of the EEG data. In both conditions, a significant phase locking effect was observed that started prior to the movement onset in the δ–θ frequency band (2–7Hz), and that was strongest at the electrodes nearest to the contralateral motor region (M1). This phase locking effect did not have a counterpart in the corresponding power spectra (i.e., amplitudes), or in the event-related potentials. Our finding suggests that phase locking in the δ–θ frequency band is a ubiquitous movement-related signal independent of how the actual movement has been initiated. We therefore suggest that phase-locked neural oscillations in the motor cortex are a prerequisite for the preparation and execution of motor actions.
•We found phase locking in the delta–theta frequency band in motor areas prior to movement execution.•Phase locking occurred irrespective of how the action was initiated.•Our results suggest that phase locking constitutes a prerequisite to trigger movement execution.
Adjustable Constrained Soft‐Tissue Dynamics Wang, B.; Zheng, M.; Barbič, J.
Computer graphics forum,
October 2020, 2020-10-00, 20201001, Volume:
39, Issue:
7
Journal Article
Peer reviewed
Open access
Physically based simulation is often combined with geometric mesh animation to add realistic soft‐body dynamics to virtual characters. This is commonly done using constraint‐based simulation whereby ...a soft‐tissue simulation is constrained to geometric animation of a subpart (or otherwise proxy representation) of the character. We observe that standard constraint‐based simulation suffers from an important flaw that limits the expressiveness of soft‐body dynamics. Namely, under correct physics, the frequency and amplitude of soft‐tissue dynamics arising from constraints (“inertial amplitude”) are coupled, and cannot be adjusted independently merely by adjusting the material properties of the model. This means that the space of physically based simulations is inherently limited and cannot capture all effects typically expected by computer animators. For example, animators need the ability to adjust the frequency, inertial amplitude, gravity sag and damping properties of the virtual character, independently from each other, as these are the primary visual characteristics of the soft‐tissue dynamics. We demonstrate that independence can be achieved by transforming the equations of motion into a non‐inertial reference coordinate frame, then scaling the resulting inertial forces, and then converting the equations of motion back to the inertial frame. Such scaling of inertia makes it possible for the animator to set the character's inertial amplitude independently from frequency. We also provide exact controls for the amount of character's gravity sag, and the damping properties. In our examples, we use linear blend skinning and pose‐space deformation for geometric mesh animation, and the Finite Element Method for soft‐body constrained simulation; but our idea of scaling inertial forces is general and applicable to other animation and simulation methods. We demonstrate our technique on several character examples.
White lupin (Lupinus albus) forms specialized cluster roots characterized by exudation of organic anions under phosphorus (P) deficiency. Here, the role of nitric oxide (NO) in P deficiency-induced ...cluster-root formation and citrate exudation was evaluated. White lupin plants were treated with the NO donor sodium nitroprusside (SNP) and scavenger or inhibitor of NO synthase under conditions of P deficiency (0 μM) or P sufficiency (50 μM). Phosphorus deficiency enhanced NO production in primary and lateral root tips, with a greater increase in cluster roots than in noncluster roots. NO concentrations decreased with cluster root development from the pre-emergent stage, through the juvenile stage, to the mature stage. The P deficiency-induced increase in NO production was inhibited by antagonists of NO synthase and xanthine oxidoreductase, suggesting the involvement of these enzymes in NO production. SNP markedly increased the number of cluster roots. Citrate exudation from different root segments in P-deficient roots was positively correlated with endogenous root NO concentrations. These findings demonstrate differential patterns of NO production in white lupin, depending on root zone, developmental stage and P nutritional status. NO appears to play a regulatory role in the formation of cluster roots and citrate exudation in white lupin under conditions of P deficiency.
Aims
Drug susceptibility testing (DST) of clinical isolates of Mycobacterium tuberculosis is critical in treating tuberculosis. We demonstrate the possibility of using a microbial sensor to perform ...DST of M. tuberculosis and shorten the time required for DST.
Methods and Results
The sensor is made of an oxygen electrode with M. tuberculosis cells attached to its surface. This sensor monitors the residual oxygen consumption of M. tuberculosis cells after treatment with anti‐TB drugs with glycerine as a carbon source. In principle, after drug pretreatment for 4–5 days, the response differences between the sensors made of drug‐sensitive isolates are distinguishable from the sensors made of drug‐resistant isolates. The susceptibility of the M. tuberculosis H37Ra strain, its mutants and 35 clinical isolates to six common anti‐TB drugs: rifampicin, isoniazid, streptomycin, ethambutol, levofloxacin and para‐aminosalicylic acid were tested using the proposed method. The results agreed well with the gold standard method (LJ) and were determined in significantly less time. The whole procedure takes approximately 11 days and therefore has the potential to inform clinical decisions.
Conclusions
To our knowledge, this is the first study that demonstrates the possible application of a dissolved oxygen electrode‐based microbial sensor in M. tuberculosis drug resistance testing. This study used the microbial sensor to perform DST of M. tuberculosis and shorten the time required for DST.
Significance and Impact of the Study
The overall detection result of the microbial sensor agreed well with that of the conventional LJ proportion method and takes less time than the existing phenotypic methods. In future studies, we will build an O2 electrode array microbial sensor reactor to enable a high‐throughput drug resistance analysis.
We present a Mathematica package, QSWalk, to simulate the time evaluation of Quantum Stochastic Walks (QSWs) on arbitrary directed and weighted graphs. QSWs are a generalization of continuous time ...quantum walks that incorporate both coherent and incoherent dynamics and as such, include both quantum walks and classical random walks as special cases. The incoherent component allows for quantum walks along directed graph edges. The dynamics of QSWs are expressed using the Lindblad formalism, originally developed for open quantum systems, which frames the problem in the language of density matrices. For a QSW on a graph of N vertices, we have a sparse superoperator in an N2-dimensional space, which can be solved efficiently using the built-in MatrixExp function in Mathematica. We illustrate the use of the QSWalk package through several example case studies.
Program summary
Program Title: QSWalk.m
Program Files doi:http://dx.doi.org/10.17632/8rwd3j9zhk.1
Licensing provisions: GNU General Public License 3 (GPL)
Programming language: Mathematica.
Nature of problem: The QSWalk package provides a method for simulating quantum stochastic walks on arbitrary (directed/undirected, weighted/unweighted) graphs.
Solution method:
For an N-vertex graph, the solution of a quantum stochastic walk can be expressed as an N2×N2 sparse matrix exponential. The QSWalk package makes use of Mathematica’s sparse linear algebra routines to solve this efficiently.
Restrictions:
The size of graphs that can be treated is constrained by available memory.
Trilayer nickelates, which exhibit a high degree of orbital polarization combined with an electron count (d^{8.67}) corresponding to overdoped cuprates, have been identified as a promising candidate ...platform for achieving high-T_{c} superconductivity. One such material, La_{4}Ni_{3}O_{8}, undergoes a semiconductor-insulator transition at ∼105 K, which was recently shown to arise from the formation of charge stripes. However, an outstanding issue has been the origin of an anomaly in the magnetic susceptibility at the transition and whether it signifies the formation of spin stripes akin to single layer nickelates. Here we report single crystal neutron diffraction measurements (both polarized and unpolarized) that establish that the ground state is indeed magnetic. The ordering is modeled as antiferromagnetic spin stripes that are commensurate with the charge stripes, the magnetic ordering occurring in individual trilayers that are essentially uncorrelated along the crystallographic c axis. A comparison of the charge and spin stripe order parameters reveals that, in contrast to single-layer nickelates such as La_{2-x}Sr_{x}NiO_{4} as well as related quasi-2D oxides including manganites, cobaltates, and cuprates, these orders uniquely appear simultaneously, thus demonstrating a stronger coupling between spin and charge than in these related low-dimensional correlated oxides.
Hypervelocity stars (HVSs) travel with velocities so high that they exceed the escape velocity of the Galaxy. Several acceleration mechanisms have been discussed. Only one HVS (US 708, HVS 2) is a ...compact helium star. Here we present a spectroscopic and kinematic analysis of US 708. Traveling with a velocity of ∼1200 kilometers per second, it is the fastest unbound star in our Galaxy. In reconstructing its trajectory, the Galactic center becomes very unlikely as an origin, which is hardly consistent with the most favored ejection mechanism for the other HVSs. Furthermore, we detected that US 708 is a fast rotator. According to our binary evolution model, it was spun-up by tidal interaction in a close binary and is likely to be the ejected donor remnant of a thermonuclear supernova.
ABSTRACT Type Iax supernovae (SNe Iax) are proposed as one new sub-class of SNe Ia since they present observational properties that are sufficiently distinct from the bulk of SNe Ia. SNe Iax are the ...most common of all types of peculiar SNe by both number and rate, with an estimated rate of occurrence of about 5%-30% of the total SN Ia rate. However, the progenitor systems of SNe Iax are still uncertain. Analyzing pre-explosion images at SN Iax positions provides a direct way to place strong constraints on the nature of progenitor systems of SNe Iax. In this work, we predict pre-explosion properties of binary companion stars in a variety of potential progenitor systems by performing detailed binary evolution calculations with the one-dimensional stellar evolution code STARS. This will be helpful for constraining progenitor systems of SNe Iax from their pre-explosion observations. With our binary evolution calculations, it is found that the non-degenerate helium (He) companion star to both a massive C/O WD ( ) and a hybrid C/O/Ne WD can provide an explanation for the observations of SN 2012Z-S1, but the hybrid WD+He star scenario is more favorable.
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