A new compact balanced ultra-wideband (UWB) bandpass filter using half mode dumbbell defected ground structure (DGS) is presented. To realise the UWB response, the ‘T’ shape multiple-mode resonator ...with short-ended stub is employed. To achieve wideband common mode (CM) suppression and compact design simultaneously, the concept of half-mode DGS is introduced in the two stacked microstrip layers. Afterwards, a balanced UWB filter is designed and measured for verifying the feasibility of the presented design method. The measured results match well with the expected results which indicate the proposed filter exhibits better than −30 dB CM suppression within the DM passband covering from 3.1 to 10.6 GHz.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infects both people and animals and may cause significant respiratory problems, including lung illness: Corona Virus Disease 2019 ...(COVID-19). Swabs taken from the throat and nose of people who have the illness or are suspected of having it have shown this pathogenic virus. When SARS-CoV-2 infects the upper and lower respiratory tracts, it may induce moderate to severe respiratory symptoms, as well as the release of pro-inflammatory cytokines including interleukin 6 (IL-6). COVID-19-induced reduction of IL-6 in an inflammatory state may have a hitherto undiscovered therapeutic impact. Many inflammatory disorders, including viral infections, has been found to be regulated by IL-6. In individuals with COVID-19, one of the primary inflammatory agents that causes inflammatory storm is IL-6. It promotes the inflammatory response of virus infection, including the virus infection caused by SARS-CoV-2, and provides a new diagnostic and therapeutic strategy. In this review article, we highlighted the functions of IL-6 in the coronavirus, especially in COVID-19, showing that IL-6 activation plays an important function in the progression of coronavirus and is a rational therapeutic goal for inflammation aimed at coronavirus.
Compared with the fuel cars, the hybrid cars has higher thermal load of engine room and has higher requirements for heat dissipation performance of the cooling module. Under idling condition, a ...hybrid car has an actual problem that higher temperature of engine room and inlet air temperature of cooling module. In this paper, a mathematic model of car thermal management is established, numerical simulations on flow and temperature fields of car were performed by using STAR-CCM+ software, the feasibility of the simulation results was verified by the thermal balance test of the cars. The results show that the reflow of hot air and the inlet air temperature of the cooling module are reduced by sealing the cooling module, the front end module and optimizing the structure of deflector, thus, the heat dissipation efficiency of the cooling module is improved.
For many years, the methods of cancer treatment are usually surgery, chemotherapy and radiation therapy. Although these methods help to improve the condition, most tumors still have a poor prognosis. ...In recent years, immunotherapy has great potential in tumor treatment. Chimeric antigen receptor T-cell immunotherapy (CAR-T) uses the patient's own T cells to express chimeric antigen receptors. Chimeric antigen receptor (CAR) recognizes tumor-associated antigens and kills tumor cells. CAR-T has achieved good results in the treatment of hematological tumors. In 2017, the FDA approved the first CAR-T for the treatment of B-cell acute lymphoblastic leukemia (ALL). In October of the same year, the FDA approved CAR-T to treat B-cell lymphoma. In order to improve and enhance the therapeutic effect, CAR-T has become a research focus in recent years. The structure of CAR, the targets of CAR-T treatment, adverse reactions and improvement measures during the treatment process are summarized. This review is an attempt to highlight recent and possibly forgotten findings of advances in chimeric antigen receptor T cell for treatment of hematological tumors.
The primary challenges in CAR-T immunotherapy include the presence of adverse side effects, an unfavorable tumor microenvironment (TME), and T-cell exhaustion. Furthermore, there is a pressing need to overcome the difficulty of expanding the production of clinical-grade cell therapies to ensure their accessibility and affordability for a larger global patient population. Display omitted
A novel compact ultra-wideband (UWB) bandpass filter (BPF) with triple sharply notched bands and good selectivity is proposed using a parallel U-shaped defected microstrip structure (UDMS). The ...initial UWB BPF comprises interdigital coupled lines and an E-shaped multiple-mode resonator to achieve two transmission zeros on both sides of the passband, thus improving skirt selectivity. Then, three parallel UDMSs are introduced, which have the properties of achieving the triple band-notched characteristics and providing a high degree of adjusting freedom. To validate the design theory, a microstrip UWB BPF with three notched bands centred at 5.2, 5.8 and 8.0 GHz, respectively, is designed and fabricated. Both the simulation and the experimental results are provided which have good agreement.
Polymethyl methacrylate (PMMA) is a material with good surface wettability and has unique and widespread applications in industrial fields. However, fabricating this material in an environmentally ...friendly way while maintaining its mechanical robustness remains a challenging task. One effective way is through the rational design of microstructure surfaces. The current study fabricated a pyramid microstructure array on a mold surface using offset-tool-servo flycutting, which was then combined with hot embossing to replicate an inverted pyramid microstructure array on a PMMA surface. Firstly, a toolpath compensation algorithm was developed to linearize the arc toolpath and reduce the cost of ultra-precision lathe. Then, the algorithm was further developed to achieve automatic linear toolpath intersection, aiming to ensure the machining accuracy and improve machining efficiency. An experiment testing the linear toolpath intersecting at 90° was conducted, fabricating a pyramid microstructure array with nanoscale roughness on the mold surface. This surface was then employed for replicating an inverted pyramid microstructure array on the PMMA surface using hot embossing. Furthermore, the accuracy of replication was evaluated, and the experimental results demonstrated excellent replication fidelity, exceeding 98%. The microstructural surface of the PMMA exhibited a change in surface wettability. The wettability test showed a water-droplet contact angle reduction from 84.8° ± 0.1° to 56.2° ± 0.1°, demonstrating a good hydrophilic effect. This study introduces a novel, environmentally friendly and high-precision method to fabricate a functional PMMA surface with an inverted pyramid microstructure array. The results of this study also provide strong technical support and theoretical guidance for micro-nanostructure functional surface machining and replicating.
A design method of compact wideband balun bandpass filter (BPF) with high selectivity based on corrugated slot is proposed here. To realize wideband balun response in compact size, metal strips are ...deployed parallel to the half‐mode corrugated slot (HMCS). Besides, the coupling of corrugated slot to the metal stripline provides the conversion of slot to microstrip structure at the balanced ports. By placing a pair of resonators at the balanced ports, a wideband balun BPF response with high selectivity can be realized. In addition, a U‐shaped resonator is also loaded at the end of the corrugated slot to suppress harmonics. Afterwards, a compact wideband balun BPF centred at 2.42 GHz with 3‐dB FBW of 45% is designed, fabricated, and measured. The effective size is 0.13λg × 0.39λg (λg is the guided wavelength of the centre frequency) and the measured results indicate that the magnitude imbalance is less than 0.45 dB and the phase imbalance is less than 4.8° within the operation frequency band.
A new design of 3-D integrated wideband filtering magneto-electric dipole antenna with high selectivity is presented. The proposed antenna is mainly composed of a horizontal planar dipole and a ...vertically oriented shorted patch antenna. A pair of C-slots is etched on the planar dipole to obtain sharp skirt selectivity near both band-edges. In addition, a slotline loaded with the patch antenna provides good impedance matching. The proposal exhibits a quasi-elliptic gain response with three introduced radiation nulls without additional filtering circuits. To verify the design concept, a prototype is fabricated and measured. The result exhibits an impedance bandwidth of 55.4% with <inline-formula> <tex-math notation="LaTeX">\text {SWR}\le 1.5 </tex-math></inline-formula> from 1.58 to 2.79 GHz. Moreover, the low back radiation levels (<inline-formula> <tex-math notation="LaTeX">{\le } -16 </tex-math></inline-formula> dB), stable radiation patterns with low cross polarization levels (<inline-formula> <tex-math notation="LaTeX">{\le } -26 </tex-math></inline-formula> dB), and an average antenna gain of 7.8 dBi are achieved within the operating band. In addition, an out-of-band suppression level, better than 17 dB, is reached.
The use of poly-ether-ether-ketone (PEEK) prosthesis during total knee arthroplasty (TKA) is a relatively new concept. Several studies have suggested that the thickness of cement penetration during ...TKA may affect the stability of the implants. The present study aimed to compare the cement penetration and clinical performance between PEEK and traditional cobalt chromium molybdenum (CoCrMo) prosthesis during TKA.
This study was a randomized controlled trial with level I of evidence. A total of 48 patients were randomly assigned to either the PEEK group (n = 24) or the CoCrMo group (n = 24). Mean bone cement penetration under the tibial baseplate was assessed radiographically in four zones in the anteroposterior view and two zones in the lateral view, in accordance with the Knee Society Scoring System. Furthermore, parameters such as the Knee Society Score (KSS), visual analogue scale (VAS) scores, complications and survivorship at 1 year postoperatively were also compared.
According to the results of this study, the mean bone cement penetration exhibited no significant difference between PEEK and CoCrMo groups (2.49 ± 0.61 mm vs. 2.53 ± 0.68 mm, p = 0.85). Additionally, there were no remarkable differences in the KSS clinical score, functional score, and VAS score between the two groups. Moreover, complications and survivorship were also statistically compared between the groups and presented no significant differences.
Based on the current findings, it can be concluded that PEEK implant present similar bone cement penetration, short-term clinical outcomes, and survivorship with traditional CoCrMo implant in TKA without added complications. Trial registration Chinese Clinical Trial Registry (ChiCTR2100047563).
Two Constructions of Binary Z-Complementary Pairs TIAN, Shucong; YANG, Meng; WANG, Jianpeng
IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences,
04/2021, Volume:
E104.A, Issue:
4
Journal Article
Peer reviewed
Z-complementary pairs (ZCPs) were proposed by Fan et al. to make up for the scarcity of Golay complementary pairs. A ZCP of odd length N is called Z-optimal if its zero correlation zone width can ...achieve the maximum value (N + 1)/2. In this letter, inserting three elements to a GCP of length L, or deleting a point of a GCP of length L, we propose two constructions of Z-optimal ZCPs with length L + 3 and L - 1, where L=2α 10β 26γ, α ≥ 1, β ≥ 0, γ ≥ 0 are integers. The proposed constructions generate ZCPs with new lengths which cannot be produced by earlier ones.
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