The current workforce crisis mandates that education providers increase the number of graduates from nursing courses. In a practice-based profession however, any growth in student numbers is ...constrained by the ability of clinical venues to accept students for clinical experience. Factors within the operating environment such as bed capacity, staffing mix and shortage of experienced clinicians to act as preceptors, clinical teachers, mentors or role models; limit the number of students that can be accommodated and both the quality and level of educational support provided. These factors are compounded in rural hospitals, where opportunities for placements can be also overlooked or ineffectively utilised.
This paper reports on a project undertaken by a rural health service, two universities and a TAFE institute. It demonstrates that a greater number of students can be accommodated when all major stakeholders accept responsibility and agree to work together to create a learning community and find ways to overcome barriers and impediments that constrain capacity. It is concluded that the capacity of a rural hospital to accept students for placement can be increased when cancellation rates are reduced, the clinical timetable rationalised and more collaborative approaches to clinical education are implemented.
Aiming for highly reactive and reversible thermochemical energy storage materials based on magnesium hydroxide, the impact of Ca2+ as dopant in magnesium hydroxide/oxide is investigated in article ...number 1700096 by Danny Müller and co‐workers. Calcium doped magnesium oxide reveals notably increased water dissociation rates, compared to pure MgO, enhancing both rate and reaction completeness of the hydration. For a series of mixed magnesium‐calcium oxides (MgxCa1−xO) with varying Ca‐contents between 0 and 40% the material of a composition Mg0.9Ca0.1O shows the fastest rehydration, transforming completely within 80 minutes to the mixed hydroxide. In consecutive dehydration/rehydration cycles reasonable cycle stability is found. A “regeneration” of the aged material (reactivity reduced by excessive cycling) in liquid water re‐establishes the initial rehydration reactivity. Density functional theory (DFT) calculations support the experimental findings, confirming that calcium doping can reduce the energy of the rate limiting water dissociation reaction exploiting both electronic and steric (size) effects.
It has previously been shown that mammary stromal cells possess the ability to maintain a fibroblast-like phenotype or differentiate
in vitro into mature adipocytes in a hormone-dependent manner. ...This paper reports that rat mammary stromal cells can also differentiate into capillary-like structures
in vitro when cultured on a reconstituted basement membrane (RBM). The differentiation potential of mammary stromal cells was compared with that of human umbilical vein endothelial cells (HUVEC) and 3T3-L1 preadipocytes. When cultured on plastic, mammary stromal cells, 3T3-L1 and HUVEC maintained a fibroblast-like phenotype. Mammary stromal cells and 3T3-L1, but not HUVEC, differentiated into mature adipocytes when cultured in adipogenic medium. When plated on reconstituted basement membrane, all three cell types began to migrate and organize themselves into an interconnected capillary network. By 18–20 h, mammary stromal cells organized into complex, highly branched capillary-like tubules whereas 3T3-L1 cells and HUVEC formed more simple structures. Cross-sectional analysis demonstrated the presence of an internal lumen. Mammary stromal cells were unique in their ability to progressively develop into a three-dimensional, highly branched network invading the RBM surface. The network formation was enhanced by the presence of vascular endothelial growth factor (VEGF) and was inhibited by the anti-angiogenic drug suramin. Western blotting analysis demonstrated the presence of the endothelial-specific marker flk-1, as well as the presence of the tight-junction-associated protein ZO-1. Mammary stromal cell differentiation into capillary structures was not a terminal state, since these cells were still able to differentiate into adipocytes when exposed to adipogenic medium. These findings suggest that mammary stromal cells differentiate into fibroblasts, adipocytes or vascular structures in a hormone- and substatum-dependent manner, and may explain the dramatic changes in stromal composition during both normal mammary gland development and tumorigenesis.
Several protein markers, including vimentin, have been used to diagnose human melanoma. Because melanoma often has metastasized by the time of diagnosis, early markers prognostic for metastatic ...potential need to be identified. Commonly, vimentin is found in mesenchymal cells, and keratins are present in epithelial cells, but recent studies report coexpression of vimentin and keratin(s) in epithelial and nonepithelial neoplasms, including some melanomas.
Our purpose was to determine whether coexpression of vimentin and keratin(s) is correlated with tumor cell invasion and metastatic behavior.
We evaluated nine human melanoma cell lines expressing vimentin and other markers of aggressive tumor behavior (HMB-45, S-100, HLA-ABC class I and HLA-DR class II histocompatibility antigens, and K8 and K18 keratins). Levels of K8 and K18 keratins were determined in the highly metastatic C8161 cell line, the poorly metastatic A375P line, and the moderately metastatic A375M line. To determine whether the presence of keratin affects migratory ability, we altered the conformational structure of keratin filaments in C8161 cells by transfection with a mutant K18 complementary DNA. We also determined messenger RNA levels of human type IV collagenase, an enzyme marker for invasion and metastasis.
In A375P cells, two-dimensional electrophoresis with Coomassie-stained gels, immunoblotting, and immunofluorescence staining showed no detectable levels of K8 or K18. A375M cells showed low levels of K8 and K18 by Western and Northern blotting, with a distinctive fluorescent subpopulation of cells. In comparison, K8 and K18 levels in C8161 cells were high in all cells. Type IV collagenase messenger RNA levels were lowest in A375P cells and highest in C8161 cells, correlating with invasive ability in vitro and metastatic potential in athymic nude mice. The transfectant clones C1070-10 and C1070-14 derived from the C8161 parent line showed dramatic morphological changes, disrupted keratin filaments, and decreased invasive and metastatic potential directly correlated with a reduction in migratory activity.
These findings show a correlation between the coexpression of vimentin with K8 and K18 keratins and the invasive and metastatic behavior of three representative human melanoma cell lines.
REPORTS OF SECTIONS 44 Applied Ecology Section 44 Aquatic Ecology Section 45 Asian Ecology Section 45 Biogeosciences Section 46 Communication & Engagement Section 48 Disease Ecology Section 50 Early ...Career Ecologist Section 51 Ecological Restoration Section 55 Education Section 56 Human Ecology Section 57 Inclusive Ecology Section 59 Invasion Ecology Section 60 Microbial Ecology Section 62 Natural History Section 64 Physiological Ecology Section 65 Plant Population Ecology Section 67 Policy Section 68 Rangeland Ecology Section 71 Researchers at Undergraduate Institutions Section 71 Soil Ecology Section 72 Statistical Ecology Section 73 Student Section 74 Theoretical Ecology Section 75 Traditional Ecological Knowledge Section 77 Vegetation Section 79 V. REPORTS OF CHAPTERS 82 Canada Chapter 82 Latin American Chapter 82 Southeastern Chapter 84 I. Reports of the Executive Director and Staff This report summarizes activities and meetings from the period August 2020–July 2021 and is submitted as an annual report from the staff. Agroecology 295 Paleoecology 100 Applied Ecology 665 Physiological Ecology 377 Aquatic Ecology 729 Plant Population Ecology 338 Asian Ecology 109 Policy 201 Biogeosciences 541 Rangeland Ecology 197 Black Ecologists 79 Researchers at Undergrad Institutions 165 Communication & Engagement 157 Soil Ecology 391 Disease Ecology 263 Statistical Ecology 400 Early Career Ecologist 510 Student 452 Ecological Restoration 539 Theoretical Ecology 334 Education 400 Traditional Ecological Knowledge 115 Environmental Justice 169 Urban Ecosystem Ecology 369 Human Ecology 73 Vegetation 360 Inclusive Ecology 121 Canada Chapter 239 Invasion Ecology 298 Great Lakes Chapter (new for 2021) Long Term Studies 241 Latin American Chapter 291 Microbial Ecology 337 Mid-Atlantic Chapter 576 Natural History 319 Southeastern Chapter 519 Open Science 74 Southwestern Chapter 552 ESA Strategic Plan In August 2019, the Governing Board adopted a new Strategic Plan (2019–2022). No, it’s a lizard pollinating South Africa’s ‘hidden flower’ – The Guardian ▪Eight-Armed Underwater Bullies: Watch Octopuses Punch Fish – New York Times ▪Study: Together, Beetle Infestation And Wildfire Permanently Altering Colorado Forests – CBS Denver ▪Rising sea levels are creating ‘ghost forests’ of coastal trees – PBS ▪Brood X Cicadas Could Cause a Bird Baby Boom – Scientific American ▪It's tick time again: The full House passed this legislation in June 2021. ○ESA sent or signed 31 advocacy letters on various topics: ▪ESC -Statement on Department of Energy Science Nominees (July 13, 2021) ▪Multisociety Climate Science Letter (June 30, 2021) ▪Multi-organization Letter to the Departments of Interior, Agriculture and State in Support of the International Year of Rangelands and Pastoralists (June 15, 2021) ▪ESA – Letter of Support for the NSF for the Future Act (May 8, 2021) ▪Multi-organization Letter in support of the Forest Inventory and Analysis (FIA) program (April 28, 2021) ▪Multi-organization Letter in Support of the America Grows Act (April 26, 2021) ▪Multi-organization Letter on Commerce, Justice and Science Allocation for FY 2022 (April 19, 2021) ▪CNSF – FY 2022 NSF Appropriations Letter (April 19, 2021) ▪ESC – FY 2022 Energy and Water Funding Allocation Statement (April 5, 2021) ▪Multi-organization Letter in Support of the RISE Act (March 24, 2021) ▪ESC – 2022 Funding Allocations Statement (March 8, 2021) ▪Multiorganization Letter in Support of Agriculture Research and Development to Agriculture Secretary Tom Vilsack (March 1, 2021) ▪ESC – FY 2022 Appropriations Statement (February 26, 2021) ▪ESC – Congratulatory Statement to Senate Energy and Water Appropriations Subcommittee Ranking Member John Kennedy (February 22, 2021) ▪ESC – Congratulatory Statement to House Science Committee Energy Subcommittee Chairman Jamaal Bowman (February 22, 2021) ▪CNSF – COVID-19 NSF Emergency Relief Letter (January 27, 2021) ▪NECIS – Recommendations to the Biden-Harris Administration, Members of the 117th Congress (January 21, 2021) ▪ESA – Comments to the NWS National Centers for Environmental Prediction (NCEP) on the management of user access of the NCEP web services (December 18, 2020) ▪ESC – Congratulatory Statement to New Appropriations
The first predictive testing for Huntington disease (HD) was based on analysis of linked polymorphic DNA markers to estimate the likelihood of inheriting the mutation for HD. Limits to accuracy ...included recombination between the DNA markers and the mutation, pedigree structure, and whether DNA samples were available from family members. With direct tests for the HD mutation, we have assessed the accuracy of results obtained by linkage approaches when requested to do so by the test individuals. For six such individuals, there was significant disparity between the tests. Three went from a decreased risk to an increased risk, while in another three the risk was decreased. Knowledge of the potential reasons for these changes in results and impact of these risk reversals on both patients and the counseling team can assist in the development of strategies for the prevention and, where necessary, management of a risk reversal in any predictive testing program.
A roundtable discussion focusing on the powerful discourse of nationalism, featuring Mary E. Hunt, Sharon D. Welch, Maria Pilar Aquino, Nami Kim, Gemma Tulud Cruz, and Kathleen Philips with ...moderation by Elisabeth Schussler Fiorenza is presented. They maintain that feminist studies in religion and feminist theology have not sufficiently discussed the politics and impact of the rhetoric of nationalism on the lives of women and argues for articulating a transnational feminism in in the context of globalization.
Roundtable Discussion Fiorenza, Elisabeth Schüssler; Hunt, Mary E.; Welch, Sharon D. ...
Journal of feminist studies in religion,
04/2005, Volume:
21, Issue:
1
Journal Article
The clinical profile of end-stage AIDS Welch, K; Kissinger, P; Bessinger, R ...
AIDS patient care and STDs,
02/1998, Volume:
12, Issue:
2
Journal Article
Peer reviewed
The purpose of this study was to describe the clinical profile of end-stage AIDS in patients 12 months before death. A cross-sectional examination of HIV-infected patients who attended a public HIV ...outpatient clinic between 1990 and 1996 and who died was conducted. The prevalence and first-time acquisition of AIDS-defining conditions 12 months before death were evaluated. The AIDS-defining conditions with the highest percentages of first-time acquisition in the last 12 months of life were progressive multifocal leukoencephalopathy (100%), lymphoma (96%), dementia (78.6%), Mycobacterium avium complex (MAC) infection (74.0%), toxoplasmosis (72.6%), and cytomegalovirus (CMV) infection (69.6%). Of the concomitant conditions studied, those with the highest percentages of first-time acquisition in the last 12 months of life were CMV with MAC (99%) and CMV with wasting (88%). Patients who acquire these AIDS-defining conditions may be eligible to receive information about end-stage options, such as hospice care. However, administration of aggressive antiretroviral treatments, such as the protease inhibitors, may affect this profile in the future, as the majority of the patients in this study were receiving the standard antiretroviral treatments of the time, primarily zidovudine.
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