Twin-field quantum key distribution can overcome the secret key capacity of repeaterless quantum key distribution via single-photon interference. However, to compensate for the channel fluctuations ...and lock the laser fluctuations, the techniques of phase tracking and phase locking are indispensable in experiment, which drastically increase experimental complexity and hinder free-space realization. We herein present an asynchronous measurement-device-independent quantum key distribution protocol that can surpass the secret key capacity even without phase tracking and phase locking. Leveraging the concept of time multiplexing, asynchronous two-photon Bell-state measurement is realized by postmatching two interference detection events. For a 1 GHz system, the new protocol reaches a transmission distance of 450 km without phase tracking. After further removing phase locking, our protocol is still capable of breaking the capacity at 270 km. Intriguingly, when using the same experimental techniques, our protocol has a higher key rate than the phase-matching-type twin-field protocol. In the presence of imperfect intensity modulation, it also has a significant advantage in terms of the transmission distance over the sending-or-not-sending-type twin-field protocol. With high key rates and accessible technology, our work provides a promising candidate for practical scalable quantum communication networks.
Endometriosis is a complex gynecological disease that affects more than 10% of women in their reproductive years. While surgery can provide temporary relief from women's pain, symptoms often return ...in as many as 75% of cases within two years. Previous literature has contributed to theories about the development of endometriosis; however, the exact pathogenesis and etiology remain elusive. We conducted a preliminary investigation into the influence of primary endometrial cells (ECs) on the development and progression of endometriosis. In vitro studies, they were involved in inducing Lipopolysaccharide (LPS) in rat-isolated primary endometrial cells, which resulted in increased nuclear factor-kappa B (NF-κB) and vascular endothelial growth factor (VEGF) mRNA gene expression (quantitative polymerase chain reaction analysis, qPCR) and protein expression (western blot analysis). Additionally, in vivo studies utilized autogenic and allogeneic transplantations (rat to rat) to investigate endometriosis-like lesion cyst size, body weight, protein levels (immunohistochemistry), and mRNA gene expression. These studies demonstrated that estrogen upregulates the gene and protein regulation of cytoskeletal (CK)-18, transforming growth factor-β (TGF-β), VEGF, and tumor necrosis factor (TNF)-α, particularly in the peritoneum. These findings may influence cell proliferation, angiogenesis, fibrosis, and inflammation markers. Consequently, this could exacerbate the occurrence and progression of endometriosis.
Ischemic stroke (IS) is a common and serious neurological condition that is highly fatal but so far no early diagnostic markers are available. Myocardial infarction-associated transcript (MIAT) is a ...long non-coding RNA (lncRNA) that could lead to IS by inducing autophagy and apoptosis in neuronal cells. However, there has been no report on the link between susceptibility to IS and the single-nucleotide polymorphisms (SNPs) of MIAT. This study aimed to investigate the association between MIAT gene polymorphisms and IS risk.
A total of 320 IS patients and 310 age-, sex- and race-matched controls were included in this study. Four polymorphisms (rs2157598, rs5761664, rs1894720, and rs9625066) were genotyped by using SNPscan technique.
Among the 4 polymorphisms of MIAT, only rs9625066 was associated with IS risk (CA vs. CC: adjusted OR = 0.55, 95% CI, 0.37-0.85, P = 0.006; AA vs. CC: adjusted OR = 0.39, 95% CI, 0.16-0.94, P = 0.036; (AA + CA vs. CC: adjusted OR = 0.53, 95% CI, 0.35-0.80, P = 0.002; A vs. C adjusted OR = 0.59, 95% CI, 0.42-0.82, P = 0.002). Haplotype analysis showed a 1.32-fold increase (95% CI, 1.05-1.67, P = 0.017) in IS risk for rs2157598-rs5761664-rs1894720-rs9625066 (A-C-G-C). Logistic regression analysis identified some independent impact factors for IS including rs9625066 AA/AC, TC, TG, HDL-C (P < 0.05).
The rs9625066 polymorphism of MIAT might be associated with IS susceptibility in Chinese population, in which AA/CA plays a protective role in IS, whereas the CC genotype increases the risk of developing IS, suggesting it might be a marker predictive of IS risk.
The miR-208 gene is one of the microRNAs now under active studies, and has been found to play significant roles in an array of cardiovascular diseases. Nevertheless, until now, no studies have ...examined the relationship between the susceptibility to ischemic stroke (IS) and genetic variations in miR-208. This study explored the association between the miR-208 polymorphisms (rs178642, rs8022522, and rs12894524) and the risk of IS.
A total of 205 cases of IS and 211 control subjects were included. The SNPscans genotyping test was employed to determine the genotypes of the three polymorphisms.
Significant correlation was observed between rs8022522 polymorphism and risk of IS on the basis of analyses of genotypes, models and alleles (GA vs. GG: adjusted OR = 2.159, 95% CI: 1.052-4.430, P = 0. 036; AA vs. GG: adjusted OR = 5.154, 95% CI: 1.123-23.660, P = 0.035; dominant model: adjusted OR = 1.746, 95% CI, 1.075-2.838, P = 0.025; G vs. A: adjusted OR = 2.451, 95% CI: 1.374-4.370, P = 0.002).
The rs8022522 polymorphism of the miR-208 gene is significantly associated with an elevated risk of ischemic stroke in Chinese.
Abstract
Cryptography promises four information security objectives, namely, confidentiality, integrity, authenticity and non-repudiation, to support trillions of transactions annually in the digital ...economy. Efficient digital signatures, ensuring integrity, authenticity and non-repudiation of data with information-theoretical security are highly urgent and intractable open problems in cryptography. Here, we propose a high-efficiency quantum digital signature (QDS) protocol using asymmetric quantum keys acquired via secret sharing, one-time universal2 hashing and a one-time pad. We just need to use a 384-bit key to sign documents of lengths up to 264 with a security bound of 10−19. If a one-megabit document is signed, the signature efficiency is improved by more than 108 times compared with previous QDS protocols. Furthermore, we build the first all-in-one quantum secure network integrating information-theoretically secure communication, digital signatures, secret sharing and conference key agreement and experimentally demonstrate this signature efficiency advantage. Our work completes the cryptography toolbox of the four information security objectives.
A new paradigm of quantum digital signatures is proposed and experimentally demonstrated, improving the efficiency by hundreds of millions of times and making it as practical as quantum secure communication.
Quantum secret sharing (QSS) is one of the basic communication primitives in future quantum networks which addresses part of the basic cryptographic tasks of multiparty communication and computation. ...Nevertheless, it is a challenge to provide a practical QSS protocol with security against general attacks. A QSS protocol that balances security and practicality is still lacking. Here, we propose a QSS protocol with simple phase encoding of coherent states among three parties. Removing the requirement of impractical entangled resources and the need for phase randomization, our protocol can be implemented with accessible technology. We provide the finite-key analysis against coherent attacks and implement a proof-of-principle experiment to demonstrate our scheme’s feasibility. Our scheme achieves a key rate of 85.3 bps under a 35 dB channel loss. Combined with security against general attacks and accessible technology, our protocol is a promising candidate for practical multiparty quantum communication networks.
Quantum digital signatures (QDS) exploit quantum laws to guarantee non-repudiation, unforgeability and transferability of messages with information-theoretic security. Current QDS protocols face two ...major restrictions, including the requirement of the symmetrization step with additional secure classical channels and the quadratic scaling of the signature rate with the probability of detection events. Here, we present an efficient QDS protocol to overcome these issues by utilizing the classical post-processing operation called post-matching method. Our protocol does not need the symmetrization step, and the signature rate scales linearly with the probability of detection events. Simulation results show that the signature rate is three orders of magnitude higher than the original protocol in a 100-km-long fiber. This protocol is compatible with existing quantum communication infrastructure, therefore we anticipate that it will play a significant role in providing digital signatures with unconditional security.
Spermatogenesis is a highly regulated process dependent on androgen receptor (AR) signaling in Sertoli cells. However, the pathogenic mechanisms of spermatogenic failure, by which loss of AR impairs ...downstream target genes to affect Sertoli cell function, remain incompletely understood. By using microarray analysis, we identified several AR-regulated genes involved in the maturation of spermatogenesis, including chromodomain Y-like protein (CDYL) and transition proteins 1 (TNP-1), that were significantly decreased in ARKO mouse testes. AR and CDYL were found to co-localize and interact in Sertoli cells. The AR-CDYL complex bound to the promoter regions of TNP1 and modulated their transcriptional activity. CDYL acts as a co-regulator of AR transactivation, and its expression is decreased in the Sertoli cells of human testes from patients with azoospermia. The androgen receptor-chromodomain Y-like protein axis plays a crucial role in regulating a network of genes essential for spermatogenesis in Sertoli cells. Disruption of this AR-CDYL regulatory axis may contribute to spermatogenic failure. These findings provide insights into novel molecular mechanisms targeting the AR-CDYL signaling pathway, which may have implications for developing new therapeutic strategies for male infertility.
Abstract
Context
Although metabolic profiles appear to play an important role in menopausal bone loss, the functional mechanisms by which metabolites influence bone mineral density (BMD) during ...menopause are largely unknown.
Objective
We aimed to systematically identify metabolites associated with BMD variation and their potential functional mechanisms in peri- and postmenopausal women.
Design and Methods
We performed serum metabolomic profiling and whole-genome sequencing for 517 perimenopausal (16%) and early postmenopausal (84%) women aged 41 to 64 years in this cross-sectional study. Partial least squares regression and general linear regression analysis were applied to identify BMD-associated metabolites, and weighted gene co-expression network analysis was performed to construct co-functional metabolite modules. Furthermore, we performed Mendelian randomization analysis to identify causal relationships between BMD-associated metabolites and BMD variation. Finally, we explored the effects of a novel prominent BMD-associated metabolite on bone metabolism through both in vivo/in vitro experiments.
Results
Twenty metabolites and a co-functional metabolite module (consisting of fatty acids) were significantly associated with BMD variation. We found dodecanoic acid (DA), within the identified module causally decreased total hip BMD. Subsequently, the in vivo experiments might support that dietary supplementation with DA could promote bone loss, as well as increase the osteoblast and osteoclast numbers in normal/ovariectomized mice. Dodecanoic acid treatment differentially promoted osteoblast and osteoclast differentiation, especially for osteoclast differentiation at higher concentrations in vitro (eg,10, 100 μM).
Conclusions
This study sheds light on metabolomic profiles associated with postmenopausal osteoporosis risk, highlighting the potential importance of fatty acids, as exemplified by DA, in regulating BMD.
Quantum digital signatures (QDSs) promise information-theoretic security against repudiation and forgery of messages. Compared with currently existing three-party QDS protocols, multiparty protocols ...have unique advantages in the practical case of more than two receivers when sending a mass message. However, complex security analysis, numerous quantum channels and low data utilization efficiency make it intractable to expand three-party to multiparty scenario. Here, based on six-state non-orthogonal encoding protocol, we propose an effective multiparty QDS framework to overcome these difficulties. The number of quantum channels in our protocol only linearly depends on the number of users. The post-matching method is introduced to enhance data utilization efficiency and make it linearly scale with the probability of detection events even for five-party scenario. Our work compensates for the absence of practical multiparty protocols, which paves the way for future QDS networks.
PDF
