Intervention: Critical physical geography Lave, Rebecca; Wilson, Matthew W.; Barron, Elizabeth S. ...
The Canadian geographer,
03/2014, Volume:
58, Issue:
1
Journal Article
Peer reviewed
A recent opinion piece rekindled debate as to whether geography's current interdisciplinary make‐up is a historical relic or an actual and potential source of intellectual vitality. Taking the latter ...position, we argue here for the benefits of sustained integration of physical and critical human geography. For reasons both political and pragmatic, we term this area of intermingled research and practice critical physical geography (CPG). CPG combines critical attention to power relations with deep knowledge of biophysical science or technology in the service of social and environmental transformation. We argue that whether practiced by individuals or teams, CPG research can improve the intellectual quality and expand the political relevance of both physical and critical human geography because it is increasingly impractical to separate analysis of natural and social systems: socio‐biophysical landscapes are as much the product of unequal power relations, histories of colonialism, and racial and gender disparities as they are of hydrology, ecology, and climate change. Here, we review existing CPG work; discuss the primary benefits of critically engaged integrative research, teaching, and practice; and offer our collective thoughts on how to make CPG work.
Résumé
Un article d'opinion paru récemment est à l'origine de la relance d'un débat qui pose la question à savoir si le fondement interdisciplinaire actuel de la géographie serait une relique historique ou une source réelle et potentielle de vitalité intellectuelle. En prenant la défense de la seconde position, nous militons en faveur des bénéfices découlant de l'intégration soutenue de la géographie physique et de la géographie humaine critique. Pour des raisons à la fois politiques et pragmatiques, nous avons nommé ce domaine de recherche et de pratique enchevêtré la géographie physique critique (GPC). C'est au service de la transformation sociale et environnementale que la GPC intègre un regard critique sur les relations de pouvoir à la connaissance profonde de la science ou de la technologie biophysique. Que se soient des individus ou des équipes qui la pratiquent, les travaux de recherche en GPC peuvent contribuer à l'amélioration de la qualité intellectuelle et à l'élargissement de la pertinence politique de la géographie humaine critique et géographie physique, compte tenu que la séparation de l'analyse des systèmes naturels et des systèmes sociaux pose des difficultés d'ordre pratique. À l'origine des paysages sociobiophysiques se trouvent autant les relations inégales de pouvoir, les histoires de colonialisme et les disparités raciales et entre les sexes que l'hydrologie, l'écologie et les changements climatiques. Dans cette partie de l'article, nous passons en revue les travaux actuels en GPC, nous engageons une discussion sur les principaux avantages des approches intégratives et véritablement critiques en recherche, dans l'enseignement et dans la pratique, et nous proposons nos réflexions collectives sur la façon d'appliquer la GPC.
This epidemiological study examined ocular and orbital lymphomas in the United States from 1995 to 2018, using data from the North American Association of Central Cancer Registries database of 87,543 ...patients with ocular and adnexal malignancies. We identified 17,878 patients (20.4%) with ocular and orbital lymphomas, with an age-standardized incidence rate (ASIR) of 2.6 persons per million (ppm). The incidence was the highest in the orbit (ASIR = 1.24), followed by the conjunctiva (ASIR = 0.57). Non-Hodgkin B-cell lymphoma was the most prevalent subtype (85.4%), particularly marginal-zone lymphoma (45.7%). Racial disparities were noted, with Asia-Pacific Islanders showing the highest incidence (orbit, 1.3 ppm). The incidence increased significantly from 1995 to 2003 (Average Percent Change, APC = 2.1%) but declined thereafter until 2018 (APC = - 0.7%). 5-year relative survival (RS) rates varied, with the highest rate for conjunctival lymphoma (100%) and the lowest for intraocular lymphoma (70.6%). Survival rates have generally improved, with an annual increase in the 5-year RS of 0.45%. This study highlights the changing epidemiological landscape, pointing to initial increases and subsequent decreases in incidence until 2003, with survival improvements likely due to advancements in treatment. These findings underscore the need for further research to investigate the root causes of these shifts and the declining incidence of ocular lymphoma.
Current management of Coats disease Sigler, Eric J., MD; Randolph, John C., MD; Calzada, Jorge I., MD ...
Survey of ophthalmology,
2014, January-February 2014, 2014 Jan-Feb, 2014-1-00, 20140101, Volume:
59, Issue:
1
Journal Article
Peer reviewed
Abstract Since its original description in 1908, Coats disease has been recognized as an idiopathic cause of severe vision loss with a remarkable diversity in clinical presentation and morphology. ...Key clinical and imaging variables are helpful in differentiating Coats disease from life-threatening malignancies, and proper management revolves around a thorough knowledge of the differential diagnosis. Despite significant advancement in scientific understanding of the disease process and clinical spectrum, the underlying etiology remains obscure, and both primary and secondary forms are recognized. With the development of anti-VEGF therapy, vitreoretinal specialists have a new, effective adjunct to the clinical management of exudates, macular edema, and serous retinal detachment. We highlight the history, diagnostic challenges, evolving clinical spectrum, and current management of Coats disease.
This paper examines one of the historical antecedents of Big Data, the social physics movement. Its origins are in the scientific revolution of the 17th century in Western Europe. But it is not named ...as such until the middle of the 19th century, and not formally institutionalized until another hundred years later when it is associated with work by George Zipf and John Stewart. Social physics is marked by the belief that large-scale statistical measurement of social variables reveals underlying relational patterns that can be explained by theories and laws found in natural science, and physics in particular. This larger epistemological position is known as monism, the idea that there is only one set of principles that applies to the explanation of both natural and social worlds. Social physics entered geography through the work of the mid-20th-century geographer William Warntz, who developed his own spatial version called “macrogeography.” It involved the computation of large data sets, made ever easier with the contemporaneous development of the computer, joined with the gravitational potential model. Our argument is that Warntz's concerns with numeracy, large data sets, machine-based computing power, relatively simple mathematical formulas drawn from natural science, and an isomorphism between natural and social worlds became grounds on which Big Data later staked its claim to knowledge; it is a past that has not yet passed.
ABSTRACT
To study the high-transition dense-gas tracers and their relationships to the star formation of the inner ∼2 kpc circumnuclear region of NGC 253, we present HCN J = 4−3 and HCO+ J = 4−3 maps ...obtained with the James Clerk Maxwell Telescope. Using the spatially resolved data, we compute the concentration indices r90/r50 for the different tracers. HCN and HCO+ 4–3 emission features tend to be centrally concentrated, which is in contrast to the shallower distribution of CO 1–0 and the stellar component. The dense-gas fraction (fdense, traced by the velocity-integrated-intensity ratios of HCN/CO and HCO+/CO) and the ratio R31 (CO 3–2/1–0) decline towards larger galactocentric distances, but increase with higher star formation rate surface density. The radial variation and the large scatter of fdense and R31 imply distinct physical conditions in different regions of the galactic disc. The relationships of fdense versus Σstellar, and SFEdense versus Σstellar are explored. SFEdense increases with higher Σstellar in this galaxy, which is inconsistent with previous work that used HCN 1–0 data. This implies that existing stellar components might have different effects on the high-J HCN and HCO+ than their low-J emission. We also find that SFEdense seems to be decreasing with higher fdense which is consistent with previous works, and it suggests that the ability of the dense gas to form stars diminishes when the average density of the gas increases. This is expected in a scenario where only the regions with high-density contrast collapse and form stars.
Patients with continuous flow destination therapy (DT) left ventricular assist devices (LVAD) comprise a heterogeneous population. We hypothesized that phenotypic clustering of individuals with DT ...LVADs by their implantation characteristics will be associated with different long-term risk profiles. We analyzed 5,999 patients with continuous flow DT LVADs in Interagency Registry for Mechanically Assisted Circulatory Support using 18 continuous variable baseline characteristics. We Z-transformed the variables and applied a Gaussian finite mixture model to perform unsupervised clustering resulting in identification of 4 phenogroups. Survival analyses considered the competing risk for cumulative incidence of transplant or the composite end point of death or heart transplant where appropriate. Phenogroup 1 (n = 1,163, 19%) was older (71 years) and primarily white (81%). Phenogroups 2 (n = 648, 11%) and 3 (n = 3,671, 61%) were of intermediate age (70 and 62 years), weight (85 and 87 kg), and ventricular size. Phenogroup 4 (n = 517, 9%) was younger (40 years), heavier (108 kg), and more racially diverse. The cumulative incidence of death, heart transplant, bleeding, LVAD malfunction, and LVAD thrombosis differed among phenogroups. The highest incidence of death and the lowest rate of heart transplant was seen in phenogroup 1 (p <0.001). For adverse outcomes, phenogroup 4 had the lowest incidence of bleeding, whereas LVAD device thrombosis and malfunction were lowest in phenogroup 1 (p <0.001 for all). Finally, the incidence of stroke, infection, and renal dysfunction were not statistically different. In conclusion, the present unsupervised machine learning analysis identified 4 phenogroups with different rates of adverse outcomes and these findings underscore the influence of phenotypic heterogeneity on post-LVAD implantation outcomes.
This paper describes the concept of “Smart Decarceration” and introduces the special issue of Criminal Justice and Behavior entitled “Research to Advance Smart Decarceration Policies, Programs, and ...Interventions.” The concept of Smart Decarceration originated nearly a decade ago as the United States reached a tipping point in mass incarceration, and it focuses on three interrelated outcomes: substantially reducing the use of incarceration and other forms of punishment; reversing racial disparities and other inequities in the criminal justice system; and promoting safety and well-being, particularly for communities that have been most impacted by mass incarceration. Ultimately, Smart Decarceration efforts should prioritize reducing the overall footprint of the criminal justice system, while building capacity outside of the system to support safety, health, and well-being. Research plays a critical role in advancing Smart Decarceration, as new forms of knowledge and evidence must be developed to replace ineffective and unjust policies and practices associated with mass incarceration. The paper discusses approaches to research that move beyond typical criminal justice outcomes and focus on the multifaceted goals of Smart Decarceration. The six articles in this special issue are introduced, highlighting their foci across ecological levels and the breadth of the criminal justice continuum, centering populations most impacted by incarceration, and identifying practice and policy innovations.
To evaluate the ability of the 8th edition of the American Joint Committee on Cancer (AJCC) Cancer Staging Manual to estimate metastatic and mortality rates for children with retinoblastoma (RB).
...International, multicenter, registry-based retrospective case series.
A total of 2190 patients from 18 ophthalmic oncology centers from 13 countries over 6 continents.
Patient-specific data fields for RB were designed and selected by subcommittee. All patients with RB with adequate records to allow tumor staging by the AJCC criteria and follow-up for metastatic disease were studied.
Metastasis-related 5- and 10-year survival data after initial tumor staging were estimated with the Kaplan-Meier method depending on AJCC clinical (cTNM) and pathological (pTNM) tumor, node, metastasis category and age, tumor laterality, and presence of heritable trait.
Of 2190 patients, the records of 2085 patients (95.2%) with 2905 eyes were complete. The median age at diagnosis was 17.0 months. A total of 1260 patients (65.4%) had unilateral RB. Among the 2085 patients, tumor categories were cT1a in 55 (2.6%), cT1b in 168 (8.1%), cT2a in 197 (9.4%), cT2b in 812 (38.9%), cT3 in 835 (40.0%), and cT4 in 18 (0.9%). Of these, 1397 eyes in 1353 patients (48.1%) were treated with enucleation. A total of 109 patients (5.2%) developed metastases and died. The median time (n = 92) from diagnosis to metastasis was 9.50 months. The 5-year Kaplan-Meier cumulative survival estimates by clinical tumor categories were 100% for category cT1a, 98% (95% confidence interval CI, 97-99) for cT1b and cT2a, 96% (95% CI, 95-97) for cT2b, 89% (95% CI, 88-90) for cT3 tumors, and 45% (95% CI, 31-59) for cT4 tumors. Risk of metastasis increased with increasing cT (and pT) category (P < 0.001). Cox proportional hazards regression analysis confirmed a higher risk of metastasis in category cT3 (hazard rate HR, 8.09; 95% CI, 2.55-25.70; P < 0.001) and cT4 (HR, 48.55; 95% CI, 12.86-183.27; P < 0.001) compared with category cT1. Age, tumor laterality, and presence of heritable traits did not influence the incidence of metastatic disease.
Multicenter, international, internet-based data sharing facilitated analysis of the 8th edition AJCC RB Staging System for metastasis-related mortality and offered a proof of concept yielding quantitative, predictive estimates per category in a large, real-life, heterogeneous patient population with RB.
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