Non-point-sources of nitrogen (N) and phosphorus (P) are recognized as major causes of eutrophication of surface waters. Adoption of policies to reduce pollution in the former German Democratic ...Republic following re-unification of Germany in 1990 provided an opportunity to examine how taking agricultural land out of production affected nutrient loads and aquatic biota in a small rural watershed. Between 1994 and 1996, soluble reactive phosphorus (SRP) and dissolved inorganic nitrogen (DIN) loads in a first-order agricultural stream decreased by >90% while instream concentrations decreased by 89% for DIN and 40% for SRP. This reduction in nutrients coincided with a decrease in precipitation (from 760 to 440 mm between 1994 and 1996) and an increase in the area of land set aside from agricultural production (from 0.3% in 1990 to a maximum of 8% in 1994). The biomass of primary producers (episammic algae) showed no clear response to this decrease in nutrient concentrations. However, benthic invertebrate composition shifted from a chironomid-amphipod to an oligochaete-gastropod dominated community in response to the decrease in DIN and changes in episammic algal abundance and sediment organic carbon concentrations. Results from our 4-year study showed reductions in soil nutrient losses combined with less precipitation resulted in less P and N in a rural stream and a change in benthic invertebrate community composition and abundance.PUBLICATION ABSTRACT
The aim of the present study was to evaluate the effects of commonly used treatment regimens such as metformin (MET) or an oral contraceptive pill (OC) containing ethynyloestradiol and cyproterone ...acetate (EE-CPA) on surrogate serum CVD risk factors and markers of endothelial dysfunction (CRP, IL-6, sVCAM) in women with PCOS.This study was conducted in a crossover design in order to compare the effects of 2 different treatment regimens in the same subject and has been registered under the number NCT01798875 in the ClinicalTrials.gov registry.42 women with PCOS (age range 18-36 years, median BMI 24.9) were randomly assigned to treatment with MET (850 mg bid) or EE-CPA containing OC for 4 months. After 2 months washout period, treatments were crossed over.Treatment with and OC increased significantly serum CRP concentrations (from 0.77 mg/l 95% CI: 0.70; 2.18 to 1.70 mg/l 95% CI: 1.65; 3.69, P<0.001). Treatment with MET slightly reduced serum CRP levels, but this difference did not reach statistical significance (P=0.08). 4 months treatment with MET or EE-CPA had no effect on serum IL-6 and sVCAM-1 concentrations (P>0.05).Treatment with EE-CPA containing OC for 4 months in women with PCOS significantly raises serum CRP. Since this rise was not accompanied by the increase in serum concentrations of IL-6, which is the most potent and effective stimulant of hepatic CRP production, we can speculate that this effect is caused by the liver first-pass effect of oral oestrogen administration. If this in turn can confer, cardiovascular risk among these women warrants further -studies.
In this work, we present the analysis of the binary microlensing event OGLE-2018-BLG-0022 that is detected toward the Galactic bulge field. The dense and continuous coverage with the high-quality ...photometry data from ground-based observations combined with the space-based Spitzer observations of this long timescale event enables us to uniquely determine the masses M 1 = 0.40 ± 0.05 M ⊙ and M 2 = 0.13 ± 0.01 M ⊙ of the individual lens components. Because the lens-source relative parallax and the vector lens-source relative proper motion are unambiguously determined, we can likewise unambiguously predict the astrometric offset between the light centroid of the magnified images (as observed by the Gaia satellite) and the true position of the source. This prediction can be tested when the individual-epoch Gaia astrometric measurements are released.
Fisheries for arctic freshwater and diadromous fish species contribute significantly to northern economies. Climate change, and to a lesser extent increased ultraviolet radiation, effects in ...freshwaters will have profound effects on fisheries from three perspectives: quantity of fish available, quality of fish available, and success of the fishers. Accordingly, substantive adaptation will very likely be required to conduct fisheries sustainably in the future as these effects take hold. A shift to flexible and rapidly responsive ‘adaptive management' of commercial fisheries will be necessary; local land- and resource-use patterns for subsistence fisheries will change; and, the nature, management and place for many recreational fisheries will change. Overall, given the complexity and uncertainty associated with climate change and related effects on arctic freshwaters and their biota, a much more conservative approach to all aspects of fishery management will be required to ensure ecosystems and key fished species retain sufficient resiliency and capacity to meet future changes.
The aim of this study was to investigate the serum concentration of adipokines, such as leptin, adiponectin, and resistin, and assess its relation to nutritional and inflammatory parameters in both ...overweight and normal weight patients on maintenance hemodialysis.
A total of 36 hemodialysis patients (27 M, 9 F; mean age 55.3 +/- 12 yr.) were examined and 23 additional healthy volunteers were recruited as the control group. The concentrations of leptin, leptin receptor, adiponectin, resistin, IL-6, TNFa and CRP were measured by ELISA. Assessment of nutritional status was determined by the levels of albumin, BMI, percentage of body fat (%F), lean body mass (LBM), and Subjective Global Assessment Score (SGA).
According to the SGA 7-points score and the albumin level, 20 patients were of good nutritional status (6-7 points), while 16 patients were mildly malnourished (4-5 points). The concentrations of CRP, resistin, adiponectin, and TNFa were statistically higher in hemodialysis patients than in the control group (p pound 0.05). The adiponectin level was inversely correlated with %F (R Spearman=-0.3; p pound 0.05). The level of leptin was positively correlated with %F as well as with BMI and SGA scores (R Spearman=0.4; p pound 0.05). Although there was no significant difference in the nutritional status between the nonoverweight (BMI 18.5-24.99) and overweight (BMI (3)25.0) groups of patients, in the nonoverweight group there were 12 patients (54.5%) with signs of mild malnutrition compared to 4 malnourished patients (28.5%) in the overweight group. Nonoverweight patients presented significantly lower leptin concentration (12.7 vs 27.8 ug/l) and higher adiponectin level (38.9 vs 32.5 ng/ml) when compared to overweight patients. The levels of IL-6 and TNFa were higher in the nonoverweight group of patients. Overweight patients also had shorter durations of stay in the hemodialysis program (30.5 vs. 87.6 months).
The results of our study indicate that lean hemodialysis patients are more prone to malnutrition and inflammation. The increased levels of leptin and decreased levels of adiponectin in the overweight hemodialysis patients support the idea of a reverse epidemiology phenomenon in this group of patients.
To determine the food-dependent effects of biologically treated, bleached-kraft pulp mill effluent on mayfly (Baetis tricaudetus Dodds) growth and development, mayflies were exposed to effluent for 2 ...weeks within artificial streams arranged in a 2 X 3 factorial design (two periphyton food levels--low, high; three concentrations--control river water, 1% effluent, 10% effluent). Although survival was not affected, the effluent had a significant stimulatory effect on growth (resulting in 20 to 50% greater body weights) and development of the wing pads. Furthermore, the initial growth and development trajectories suggest that effluent-exposed mayflies may emerge sooner and at a larger size than nonexposed individuals. A key result was that the stimulatory effects occurred within both the low- and high-food treatments. Thus, the effluent-exposed mayflies grew faster than even the high-food control animals, which already had access to more food than they could eat throughout the experiment. This shows that the stimulatory effect of the effluent on the mayflies involved more than just an increase in food availability due to enhanced algal growth in response to nutrients in the effluent. Three possible mechanisms for this growth-enhancement effect are that the effluent (a) increased the nutritive value of the food, (b) enhanced the palatability of the periphyton, inducing increased mayfly feeding, and/or (c) directly stimulated increased mayfly growth via hormonal or other growth-stimulation effects. Further work is required to determine whether the growth stimulation occurred at the expense of future reproductive output
Development of the kaon tagging system for the NA62 experiment at CERN Goudzovski, Evgueni; Krivda, Marian; Lazzeroni, Cristina ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
11/2015, Volume:
801
Journal Article
Peer reviewed
The NA62 experiment at CERN aims to make a precision measurement of the ultra-rare decay K+→π+νν¯, and relies on a differential Cherenkov detector (KTAG) to identify charged kaons at an average rate ...of 50MHz in a 750MHz unseparated hadron beam. The experimental sensitivity of NA62 to K-decay branching ratios (BR) of 10−11 requires a time resolution for the KTAG of better than 100ps, an efficiency better than 95% and a contamination of the kaon sample that is smaller than 10−4. A prototype version of the detector was tested in 2012, during the first NA62 technical run, in which the required resolution of 100ps was achieved and the necessary functionality of the light collection system and electronics was demonstrated.
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