ABSTRACT Very recently, Spitler et al. and Scholz et al. reported their detections of 16 additional bright bursts in the direction of the fast radio burst (FRB) 121102. This repeating FRB is ...inconsistent with all of the catastrophic event models put forward previously for hypothetically non-repeating FRBs. Here, we propose a different model, in which highly magnetized pulsars travel through the asteroid belts of other stars. We show that a repeating FRB could originate from such a pulsar encountering a large number of asteroids in the belt. During each pulsar-asteroid impact, an electric field induced outside of the asteroid has such a large component parallel to the stellar magnetic field that electrons are torn off the asteroidal surface and accelerated to ultra-relativistic energies instantaneously. The subsequent movement of these electrons along magnetic field lines will cause coherent curvature radiation, which can account for all of the properties of an FRB. In addition, this model can self-consistently explain the typical duration, luminosity, and repetitive rate of the 17 bursts of FRB 121102. The predicted occurrence rate of repeating FRB sources may imply that our model would be testable in the next few years.
The objective of this research was to develop an alkali pretreatment process prior to anaerobic digestion (AD) of pulp and paper sludge (PPS) to improve the methane productivity. Different ...concentrations of sodium hydroxide solution were used to pretreat PPS, and then followed by AD of PPS and monosodium glutamate waste liquor (MGWL).
Laboratory-scale experiments were carried out in completely mixed bioreactors, 1
L capacity with 700
mL worked. Optimal amount of sodium hydroxide for organics solubilization in the step of pretreatment was 8
g NaOH/100
g TS
sludge. Under this condition, the PPS flocs structure was well disrupted resulting in the void rate and fiber size decreased after pretreatment, and SCOD increased up to 83% as well as the peak value of VFA concentration attained 1040
mg
acetic
acid/L during AD. The AD efficiency of PPS with and without pretreatment was evaluated. The highest methane yield under optimal pretreatment condition was 0.32
m
3 CH
4/kg
VS
removal, 183.5% of the control. The results indicated that alkali/NaOH pretreatment could be an effective method for improving methane yield with PPS.
B-cell lymphoma/leukemia 10 (BCL10) is an apoptotic regulatory protein related to advanced TNM stage and disease recurrence in oral squamous cell carcinoma (OSCC). However, the regulatory mechanism ...of BCL10 in OSCC progression is still unknown. Here, we showed that knockdown of endogenous BCL10 could significantly reduce cell migration and invasion abilities, retard cell proliferation by G0/G1 phase accumulation and inhibit tumorigenicity in vivo. In molecular level, we identified S100P as a crucial downstream effector of BCL10-inhibited OSCC progression by high-throughput microarray analysis. S100P messenger RNA and protein expression levels were significantly diminished in silenced-BCL10 clones, and transfected S100P expression plasmids restored migration, invasion, proliferation abilities and tumorigenicity in shBCL10 transfectants. Furthermore, we provided evidence that BCL10 regulated S100P expression through signal transducers and activators of transcription 1 (STAT1) and activating transcription factor 4 (ATF4). Knockdown of BCL10 decreased S100P promoter activity, but showed no effect in truncated STAT1/ATF4 S100P promoter. In addition, we also found that the P50/P65 signaling pathway was involved in BCL10-enhanced OSCC progression. Restored S100P in silenced-BCL10 clones could markedly reverse P65 activation via outside-in signaling. Taken together, we discovered a novel axis of BCL10-regulated OSCC progression via STAT1/ATF4/S100P/P65 signaling, which could predict the prognosis of OSCC and will be beneficial for developing therapeutic strategy against advanced OSCC.
PDF
