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  • Phase separation at the synapse
    Chen, Xudong; Wu, Xiandeng; Wu, Haowei ... Nature neuroscience, 03/2020, Volume: 23, Issue: 3
    Journal Article
    Peer reviewed

    Emerging evidence indicates that liquid-liquid phase separation, the formation of a condensed molecular assembly within another diluted aqueous solution, is a means for cells to organize highly ...
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  • Formation of biological con... Formation of biological condensates via phase separation: Characteristics, analytical methods, and physiological implications
    Feng, Zhe; Chen, Xudong; Wu, Xiandeng ... Journal of biological chemistry/˜The œJournal of biological chemistry, 10/2019, Volume: 294, Issue: 40
    Journal Article
    Peer reviewed
    Open access

    Liquid–liquid phase separation (LLPS) facilitates the formation of condensed biological assemblies with well-delineated physical boundaries, but without lipid membrane barriers. LLPS is increasingly ...
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  • RIM and RIM-BP Form Presyna... RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation
    Wu, Xiandeng; Cai, Qixu; Shen, Zeyu ... Molecular cell, 03/2019, Volume: 73, Issue: 5
    Journal Article
    Peer reviewed
    Open access

    Both the timing and kinetics of neurotransmitter release depend on the positioning of clustered Ca2+ channels in active zones to docked synaptic vesicles on presynaptic plasma membranes. However, how ...
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  • Vesicle Tethering on the Su... Vesicle Tethering on the Surface of Phase-Separated Active Zone Condensates
    Wu, Xiandeng; Ganzella, Marcelo; Zhou, Jinchuan ... Molecular cell, 01/2021, Volume: 81, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Tethering of synaptic vesicles (SVs) to the active zone determines synaptic strength, although the molecular basis governing SV tethering is elusive. Here, we discover that small unilamellar vesicles ...
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  • CaMKIIα-driven, phosphatase... CaMKIIα-driven, phosphatase-checked postsynaptic plasticity via phase separation
    Cai, Qixu; Zeng, Menglong; Wu, Xiandeng ... Cell research, 01/2021, Volume: 31, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Ca /calmodulin-dependent kinase IIα (CaMKIIα) is essential for synaptic plasticity and learning by decoding synaptic Ca oscillations. Despite decades of extensive research, new mechanisms underlying ...
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  • Structural Basis for the Hi... Structural Basis for the High-Affinity Interaction between CASK and Mint1
    Wu, Xiandeng; Cai, Qixu; Chen, Yiyun ... Structure, 06/2020, Volume: 28, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    CASK forms an evolutionarily conserved tripartite complex with Mint1 and Veli critical for neuronal synaptic transmission and cell polarity. The CASK CaM kinase (CaMK) domain, in addition to ...
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  • Liquid-Liquid Phase Separat... Liquid-Liquid Phase Separation in Neuronal Development and Synaptic Signaling
    Wu, Xiandeng; Cai, Qixu; Feng, Zhe ... Developmental cell, 10/2020, Volume: 55, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Formation of biomolecular condensates that are not enclosed by membranes via liquid-liquid phase separation (LLPS) is a general strategy that cells adopt to organize membraneless subcellular ...
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  • Interactions between Membra... Interactions between Membraneless Condensates and Membranous Organelles at the Presynapse: A Phase Separation View of Synaptic Vesicle Cycle
    Wu, Xiandeng; Qiu, Hua; Zhang, Mingjie Journal of Molecular Biology/Journal of molecular biology, 01/2023, Volume: 435, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Display omitted •Presynaptic bouton contains multiple synaptic vesicle-containing sub-compartments.•SVs and proteins in different sub-compartments phase separate with distinct modes.•Phase separation ...
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  • Presynaptic bouton compartm... Presynaptic bouton compartmentalization and postsynaptic density-mediated glutamate receptor clustering via phase separation
    Feng, Zhe; Wu, Xiandeng; Zhang, Mingjie Neuropharmacology, 08/2021, Volume: 193
    Journal Article
    Peer reviewed

    Neuronal synapses encompass three compartments: presynaptic axon terminal, synaptic cleft, and postsynaptic dendrite. Each compartment contains densely packed molecular machineries that are involved ...
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  • Demixing is a default process for biological condensates formed via phase separation
    Zhu, Shihan; Shen, Zeyu; Wu, Xiandeng ... Science (American Association for the Advancement of Science), 2024-May-24, Volume: 384, Issue: 6698
    Journal Article
    Peer reviewed

    Excitatory and inhibitory synapses do not overlap even when formed on one submicron-sized dendritic protrusion. How excitatory and inhibitory postsynaptic cytomatrices or densities (e/iPSDs) are ...
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