With the increasing prominence of data security in cloud storage, we propose a practical and robust cloud storage scheme, which uses quantum random numbers as encryption keys, disperses the keys ...using Shamir’s secret sharing scheme, applies erasure coding to the ciphertext, and securely transmits the data through quantum key distribution protected networks to the distributed clouds. This system offers several key advantages, including quantum-level security, fault tolerance, and storage space saving. To validate its feasibility, we conduct comprehensive experimental tests covering essential functionalities such as encryption/decryption, key preservation, and data storage. By successfully demonstrating the effectiveness of our proposal, we aim to accelerate the application of quantum technology in cloud storage.
Immunotherapeutics are frequently associated with adverse side effects due to the elicitation of global immune modulation. To lower the risk of these side effects, recombinant DNA technology is ...employed to enhance the selectivity of cell targeting by genetically fusing different biomolecules, yielding new species referred to as multi-specific biologics. The design of new multi-specific biologics is a central challenge for the realization of new immunotherapies. To understand the molecular determinants responsible for regulating the binding between multi-specific biologics and surface-bound membrane receptors, we developed a multiscale computational framework that integrates various simulation approaches covering different timescales and spatial resolutions. Our model system of multi-specific biologics contains two natural ligands of immune receptors, which are covalently tethered by a peptide linker. Using this method, a number of interesting features of multi-specific biologics were identified. Our study therefore provides an important strategy to design the next-generation biologics for immunotherapy.
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•Two proteins are connected by different linkers as a model of bispecific biologics•Conformational dynamics of biologics are captured by microsecond MD simulations•Coarse-grained simulations are used to test binding between biologics and receptors•Biologics with long and flexible linkers are more efficient in targeting receptors
Immunology; Therapeutics
Fluid material can recover from damage rapidly with no demand of external triggering in contrast with the traditional self-healing material which presents low healing efficiency and demands external ...triggering, such as heat, light, moisture, electricity, etc. However, due to its low viscosity, fluid material is easy to flow away from the surface and thus it is difficult to form a stable coating on the surface to provide practical corrosion resistance to the substrate. Herein, a stable and superfast self-healing coating on steel substrate has been obtained by incorporating carbon nanotube (CNT) into the fluid matrix of epoxy resin (EP) or silicone oil (OIL). To further achieve the active corrosion resistance, 1H, 1H, 2H, 2H- perfluorooctyltriethoxysilane (PTES) which can react with the water inside the coating is added. The coating possesses superfast (tens of seconds) self-healing properties against millimeter-scale scratch repeatedly and excellent corrosion resistance in the aqueous solution of HCl (1 M) and NaOH (1 M). In-situ self-healing and electrochemical behavior in scanning vibrating electrode technique (SVET) measurement indicate the fluid coating possesses infinite self-healing capacity theoretically. Due to its excellent durability and infinite self-healing capacity with short responding time, the optimized fluid coating can be a smart corrosion barrier coating for metals.
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•Development of self-healing material was discussed in view of the features of healing strategy•Fluid based self-healing materials behaved superfast and infinite healing potential•Balance of fluidity and stability was critical for fluid based slef-healing materials•SVET results illustrated self-healing can be infinitely displayed by delaying 100 s•Self-healing coating exhibited excellent corrosion resistance without triggering
The complex marine environment in the splash zone and the deep-sea area is always raising stern challenges for the steel structures served in the offshore facilitates. Compared with other coating ...fillers, the carbon fiber (CF), with outstanding mechanical strength, is a suitable candidate filler for coating reinforcement. However, CF has a poor compatibility with organic resin, which could cause defects inside the coating, and result in coating failure further. Hence, we used dopamine to modify CF surface (CF-PDA) and introduced CF-PDA into the epoxy coating as reinforced additive to improve the erosion wear resistance and anti-corrosion ability of coating. The interfacial shear strength (IFSS) of CF-PDA/epoxy was increased by 32.20%, compared with CF/epoxy. After 120 h immersion under 30 MPa pressure, the |Z|0.01 Hz of the CF-PDA/EP (1.04 × 108 Ω cm2) was obviously higher than EP, and the interfaces of steel/coating and CF-PDA/resin were not failure evidently. Meantime, after the erosion wear test, compared with EP, the mass loss and the volume loss of CF-PDA/EP were decreased by 19.40% and 25.72%, respectively. Then, the failure process of coatings was discussed during erosion wear test, and we explained the relationship between the erosion wear resistance of coatings and interfacial strength of CF-PDA/epoxy resin.
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•Carbon fiber was modified through dopamine via chemical grafting and introduced into epoxy coating as reinforced additive.•Corrosion and erosion wear resistance of CF-PDA/EP were tested by simulating the condition of deep-sea area and splash zone.•The process of erosion and the erosion wear resistance mechanism of carbon fiber were discussed in detail.
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•Coral-like PDA layer was constructed on the surface of glass fiber by regulating the reaction concentration of dopamine.•CT confirmed that glass fiber with coral-like PDA layer had ...good dispersion in epoxy resin.•(PDA1.5@GF)/EP coating displayed the best mechanical properties, anti-wear and erosion resistance performance.•The coral-like PDA layer could form mechanical meshing between GF and EP, thus significantly enhancing the erosion resistance of GF/EP coating.
Glass fiber (GF) reinforced epoxy resin composite materials are widely used in wind power, automobiles, and ships, etc. The failure of glass fiber reinforced epoxy resin composites (GF/EP) is mainly attributed to the smooth surface and chemical inertness of GF. Dopamine, extracted from the adhesive protein secreted by mussels, exhibits excellent adhesion performance especially in wet environments. Thence, we constructed a coral-like layer of dopamine nanoparticles on the surface of glass fiber (PDA@GF) by self-surface polymerization deposition, which could simultaneously improve the chemical activity and roughness of the fiber surface, and form mechanical meshing and chemical bonding with the epoxy resin, thereby enhancing the interfacial adhesion strength between GF and EP. PDA layer with different surface morphologies were constructed on the GF surface by finely adjusting the reaction parameters, and the influences of surface morphologies on the mechanical performance of GF/EP coatings were explored. Based on the results obtained from tensile test, friction test, and erosion test, it was evident that the PDA@GF/EP composite material exhibited superior mechanical properties when the PDA layer exhibited a coral-like morphology, in comparison to the other two kinds of surface morphologies. Meanwhile, the dispersion of the fiber within the epoxy resin was examined using X-ray computed tomography (X-ray CT). On this basis, we investigated the anti-wear performance and erosion resistance of composite coatings with different fiber contents, furthermore, we revealed the anti-wear and anti-erosion mechanism.
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•It was observed that lubricants inhibited the growth of algae biofilm.•The binary structure was prepared by carbon fiber, epoxy resin and acetone.•The SLIPS-EP/CF has the best ...antifouling property for its long term oil storage.
Fabricating slippery lubricant-infused porous surfaces (SLIPS), typically composed of lubricant and microstructured surface, is an effective way to solve the problem of marine anti-fouling. In the present work, acetone acted as a volatile solvent, and epoxy resin acted as a linking agent were mixed with one-dimensional material with different length (300-nm carbon nanotubes, 300-μm carbon fiber, and 1-mm polyacrylonitrile fiber). After acetone volatilized, one-dimensional materials with different length could form various kind of internal or surface structures. 300-μm carbon fiber could form a hierarchical structure with both internal holes and vertical needle-shaped structures, which effectively ensured the storage stability of lubricant in the structure. And through 21 days of algae attachment experiment, compared with the bare epoxy resin, the lubricant-infused carbon fiber structure (SLIPS-EP/CF) displayed superior anti-fouling performance with the reduction rate of chlorella was 91.4% and the phaeodactylum tricornutum was 77.8%. Additionally, the TEM and SEM analysis showed the attachment of algae to the surface of lubricant, and it was interesting to observe that algae could be wrapped by silicone oil and could not produce algae biofilm, which was presented by the first time. Since the formation of algae biofilm was inhibited, a large number of algae attachment was avoided, thereby realizing effective antifouling performance.
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