We describe the procedure used to flux calibrate the three-band submillimetre photometer in the Spectral and Photometric Imaging Receiver instrument on the Herschel Space Observatory. This includes ...the equations describing the calibration scheme, a justification for using Neptune as the primary calibration source, a description of the observations and data processing procedures used to derive flux calibration parameters (for converting from voltage to flux density) for every bolometer in each array, an analysis of the error budget in the flux calibration for the individual bolometers and tests of the flux calibration on observations of primary and secondary calibrators. The procedure for deriving the flux calibration parameters is divided into two parts. In the first part, we use observations of astronomical sources in conjunction with the operation of the photometer internal calibration source to derive the unscaled derivatives of the flux calibration curves. To scale the calibration curves in Jy beam−1 V−1, we then use observations of Neptune in which the beam of each bolometer is mapped using a very fine scan pattern. The total instrumental uncertainties in the flux calibration for most individual bolometers is ∼0.5 per cent, although a few bolometers have uncertainties of ∼1-5 per cent because of issues with the Neptune observations. Based on application of the flux calibration parameters to Neptune observations performed using typical scan map observing modes, we determined that measurements from each array as a whole have instrumental uncertainties of 1.5 per cent. This is considerably less than the absolute calibration uncertainty associated with the model of Neptune, which is estimated at 4 per cent.
Despite their crucial role in health and disease, our knowledge of immune cells within human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 adult donors by ...single-cell RNA sequencing and VDJ sequencing generating a dataset of ~360,000 cells. To systematically resolve immune cell heterogeneity across tissues, we developed CellTypist, a machine learning tool for rapid and precise cell type annotation. Using this approach, combined with detailed curation, we determined the tissue distribution of finely phenotyped immune cell types, revealing hitherto unappreciated tissue-specific features and clonal architecture of T and B cells. Our multitissue approach lays the foundation for identifying highly resolved immune cell types by leveraging a common reference dataset, tissue-integrated expression analysis, and antigen receptor sequencing.
Summary
The mu‐opioid receptor (MOR), a membrane‐bound G protein‐coupled receptor, is the main target for opioids in the nervous system. MOR1 has been found in several types of cancer cells and ...reported to be involved in tumor progression and metastasis. However, the expression and clinical significance of MOR1 in esophageal squamous cell carcinoma (ESCC) remain unclear. In our study, the expression of MOR1 was confirmed in ESCC cell lines (KYSE180, KYSE150, and EC109) by Western blot. MOR1 was also detected on tissue microarrays of ESCC samples in 239 cases using immunohistochemical staining. We found that MOR1 was mainly located in the cytoplasm and occasionally occurred in the membrane or nucleus of ESCC cells. Moreover, results indicated that MOR1 expression in the cytoplasm was associated with lymph node metastasis (R = 0.164, P = 0.008, Kendall's tau‐b‐test). No more associations were found between MOR1 expression status and other clinical parameters. However, no statistical significant differences were found between MOR1 expression in the cytoplasm, nucleus/membrane, and the overall survival of ESCC patients (P = 0.848; P = 0.167; P = 0.428, respectively, log‐rank test). Our results suggest that the cytoplasmic MOR1 may be a high‐risk factor for lymph node metastasis of ESCC patients. We also hypothesize that MOR1 agonists used in ESCC patients should be prudent, and opioid receptor antagonists may be novel therapeutic drugs for ESCC patients.
Despite doubling of yields of major grain crops since the 1950s, more than one in seven people suffer from malnutrition (1). Global population is growing; demand for food, especially meat, is ...increasing; much land most suitable for annual crops is already in use; and production of nonfood goods (e.g., biofuels) increasingly competes with food production for land (2). The best lands have soils at low or moderate risk of degradation under annual grain production but make up only 12.6% of global land area (16.5 million km super(2)) (3). Supporting more than 50% of world population is another 43.7 million km super(2) of marginal lands (33.5% of global land area), at high risk of degradation under annual grain production but otherwise capable of producing crops (3). Global food security depends on annual grains- cereals, oilseeds, and legumes-planted on almost 70% of croplands, which combined supply a similar portion of human calories (4, 5). Annual grain production, though, often compromises essential ecosystem services, pushing some beyond sustainable boundaries (5). To ensure food and ecosystem security, farmers need more options to produce grains under different, generally less favorable circumstances than those under which increases in food security were achieved this past century. Development of perennial versions of important grain crops could expand options.
We compared the effects of salt-stresses (SS, 1: 1 molar ratio of NaCl to Na₂SO₄) and alkali-stresses (AS, 1: 1 molar ratio of NaHCO₃ to Na₂CO₃) on the growth, photosynthesis, solute accumulation, ...and ion balance of barley seedlings, to elucidate the mechanism of AS (high-pH) damage to plants and the physiological adaptive mechanism of plants to AS. The effects of SS on the water content, root system activity, membrane permeability, and the content of photosynthetic pigments were much less than those of AS. However, AS damaged root function, photosynthetic pigments, and the membrane system, led to the severe reductions in water content, root system activity, content of photosynthetic pigments, and net photosynthetic rate, and a sharp increase in electrolyte leakage rate. Moreover, with salinity higher than 60 mM, Na⁺ content increased slowly under SS and sharply under AS. This indicates that high-pH caused by AS might interfere with control of Na⁺ uptake in roots and increase intracellular Na⁺ to a toxic level, which may be the main cause of some damage emerging under higher AS. Under SS, barley accumulated organic acids, Cl⁻, SO₄ ²⁻, and NO₃ ⁻ to balance the massive influx of cations, the contribution of inorganic ions to ion balance was greater than that of organic acids. However, AS might inhibit absorptions of NO₃ ⁻ and Cl⁻, enhance organic acid synthesis, and SO₄ ²⁻ absorption to maintain intracellular ion balance and stable pH.
The change in mean-square nuclear charge radii δ⟨r^{2}⟩ along the even-A tin isotopic chain ^{108-134}Sn has been investigated by means of collinear laser spectroscopy at ISOLDE/CERN using the atomic ...transitions 5p^{2} ^{1}S_{0}→5p6 s^{1}P_{1} and 5p^{2} ^{3}P_{0}→5p6s ^{3}P_{1}. With the determination of the charge radius of ^{134}Sn and corrected values for some of the neutron-rich isotopes, the evolution of the charge radii across the N=82 shell closure is established. A clear kink at the doubly magic ^{132}Sn is revealed, similar to what has been observed at N=82 in other isotopic chains with larger proton numbers, and at the N=126 shell closure in doubly magic ^{208}Pb. While most standard nuclear density functional calculations struggle with a consistent explanation of these discontinuities, we demonstrate that a recently developed Fayans energy density functional provides a coherent description of the kinks at both doubly magic nuclei, ^{132}Sn and ^{208}Pb, without sacrificing the overall performance. A multiple correlation analysis leads to the conclusion that both kinks are related to pairing and surface effects.
Abstract
The interactions between electrons and antiferromagnetic magnons (AFMMs) are important for a large class of correlated materials. For example, they are the most plausible pairing glues in ...high-temperature superconductors, such as cuprates and iron-based superconductors. However, unlike electron-phonon interactions (EPIs), clear-cut observations regarding how electron-AFMM interactions (EAIs) affect the band structure are still lacking. Consequently, critical information on the EAIs, such as its strength and doping dependence, remains elusive. Here we directly observe that EAIs induce a kink structure in the band dispersion of Ba
1−
x
K
x
Mn
2
As
2
, and subsequently unveil several key characteristics of EAIs. We found that the coupling constant of EAIs can be as large as 5.4, and it shows strong doping dependence and temperature dependence, all in stark contrast to the behaviors of EPIs. The colossal renormalization of electron bands by EAIs enhances the density of states at Fermi energy, which is likely driving the emergent ferromagnetic state in Ba
1−
x
K
x
Mn
2
As
2
through a Stoner-like mechanism with mixed itinerant-local character. Our results expand the current knowledge of EAIs, which may facilitate the further understanding of many correlated materials where EAIs play a critical role.
In this work, the mechanism of the ethanol oxidation reaction (EOR) on a palladium electrode was studied using the cyclic voltammetry method. The dissociative adsorption of ethanol was found to ...proceed rather quickly and the rate-determining step was the removal of the adsorbed ethoxi by the adsorbed hydroxyl on the Pd electrode. The Tafel slope was found to be 130
mV
dec
−1 at lower potentials, which suggests that the adsorption of OH
− ions follows the Temkin-type isotherm on the Pd electrode. In comparison, the Tafel slope increased gradually to 250
mV
dec
−1 at higher potentials. The change in the Tafel slope indicated that, at higher potentials, the kinetics is not only affected by the adsorption of the OH
− ions, but also by the formation of the inactive oxide layer on the Pd electrode.
We used wide-area surveys over 39 deg2 by the HerMES (Herschel Multi-tiered Extragalactic Survey) collaboration, performed with the Herschel
Observatory SPIRE multiwavelength camera, to estimate the ...low-redshift, 0.02 < z < 0.5, monochromatic luminosity functions (LFs) of galaxies at 250, 350 and 500 μm. Within this redshift interval, we detected 7087 sources in five independent sky areas, ∼40 per cent of which have spectroscopic redshifts, while for the remaining objects photometric redshifts were used. The SPIRE LFs in different fields did not show any field-to-field variations beyond the small differences to be expected from cosmic variance. SPIRE flux densities were also combined with Spitzer photometry and multiwavelength archival data to perform a complete spectral energy distribution fitting analysis of SPIRE detected sources to calculate precise k-corrections, as well as the bolometric infrared (IR; 8–1000 μm) LFs and their low-z evolution from a combination of statistical estimators. Integration of the latter prompted us to also compute the local luminosity density and the comoving star formation rate density (SFRD) for our sources, and to compare them with theoretical predictions of galaxy formation models. The LFs show significant and rapid luminosity evolution already at low redshifts, 0.02 < z < 0.2, with L
$_{\text{IR}}^{\ast } \propto (1+z)^{6.0\pm 0.4}$
and
$\Phi _{\text{IR}}^{\ast } \propto (1+z)^{-2.1\pm 0.4}$
, L
$_{250}^{\ast } \propto (1+z)^{5.3\pm 0.2}$
and
$\Phi _{250}^{\ast } \propto (1+z)^{-0.6\pm 0.4}$
estimated using the IR bolometric and the 250 μm LFs, respectively. Converting our IR LD estimate into an SFRD assuming a standard Salpeter initial mass function and including the unobscured contribution based on the UV dust-uncorrected emission from local galaxies, we estimate an SFRD scaling of SFRD0 + 0.08z, where SFRD0 ≃ (1.9 ± 0.03) × 10−2 M⊙ Mpc−3 is our total SFRD estimate at z ∼ 0.02.
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