To evaluate the expressions of circulating angiogenic factors affected by pamidronic acid (PA) intravenous infusion in bone metastatic breast cancer patients and the impact on their prognosis.
...Peripheral blood of ten bone metastatic breast cancer patients was collected for serum insulin-like growth factor-1 (IGF-1) and platelet endothelial cell adhesion molecule-1 expression detection just before and 2 days after PA infusion.
Both IGF-1 and platelet endothelial cell adhesion molecule-1 concentrations decreased after PA treatment for 48 hours (P<0.05). Modification was defined as >20% decrease recorded 2 days after PA administration. The decrease of IGF-1 was more significant in breast cancer patients who had received previous hormonotherapy. Moreover, the progression-free survival of first-line chemotherapy treatment of IGF-1 modified patients was longer than that of IGF-1 unmodified patients (P=0.009).
PA treatment could suppress circulating serum IGF-1 and platelet endothelial cell adhesion molecule-1 concentrations; moreover, the prognosis of patients in IGF-1 unmodified group was relatively poor.
ABSTRACT
Using confocal microscopy, X‐ray microanalysis and the scanning ion‐selective electrode technique, we investigated the signalling of H
2
O
2
, cytosolic Ca
2+
(Ca
2+
cyt
) and the PM H
+
...‐coupled transport system in K
+
/Na
+
homeostasis control in NaCl‐stressed calluses of
Populus euphratica
. An obvious Na
+
/H
+
antiport was seen in salinized cells; however, NaCl stress caused a net K
+
efflux, because of the salt‐induced membrane depolarization. H
2
O
2
levels, regulated upwards by salinity, contributed to ionic homeostasis, because H
2
O
2
restrictions by DPI or DMTU caused enhanced K
+
efflux and decreased Na
+
/H
+
antiport activity. NaCl induced a net Ca
2+
influx and a subsequent rise of Ca
2+
cyt
, which is involved in H
2
O
2
‐mediated K
+
/Na
+
homeostasis in salinized
P. euphratica
cells. When callus cells were pretreated with inhibitors of the Na
+
/H
+
antiport system, the NaCl‐induced elevation of H
2
O
2
and Ca
2+
cyt
was correspondingly restricted, leading to a greater K
+
efflux and a more pronounced reduction in Na
+
/H
+
antiport activity. Results suggest that the PM H
+
‐coupled transport system mediates H
+
translocation and triggers the stress signalling of H
2
O
2
and Ca
2+
, which results in a K
+
/Na
+
homeostasis via mediations of K
+
channels and the Na
+
/H
+
antiport system in the PM of NaCl‐stressed cells. Accordingly, a salt stress signalling pathway of
P. euphratica
cells is proposed.
This study aimed to detect the difference in resting cerebral activities between ischemic stroke pa- tients and healthy participants, define the abnormal site, and provide new evidence for ...pathological mechanisms, clinical diagnosis, prognosis prediction and efficacy evaluation of ischemic stroke. At present, the majority of functional magnetic resonance imaging studies focus on the motor dysfunc- tion and the acute stage of ischemic stroke. This study recruited 15 right-handed ischemic stroke patients at subacute stage （15 days to 11.5 weeks） and 15 age-matched healthy participants. A rest- ing-state functional magnetic resonance imaging scan was performed on each subject to detect cerebral activity. Regional homogeneity analysis was used to investigate the difference in cerebral activities between ischemic stroke patients and healthy participants. The results showed that the ischemic stroke patients had lower regional homogeneity in anterior cingulate and left cerebrum and higher regional homogeneity in cerebellum, left precuneus and left frontal lobe, compared with healthy participants. The experimental findings demonstrate that the areas in which regional homogeneity was different between ischemic stroke patients and healthy participants are in the cerebellum, left precuneus, left triangle inferior frontal gyrus, left inferior temporal gyrus and anterior cingulate. These locations, related to the motor, sensory and emotion areas, are likely po- tential targets for the neural regeneration of subacute ischemic stroke patients.
Waterlogging is a major abiotic stress limiting barley （Hordeum vulgare L.） yield and its stability in areas with excessive rainfall. Identification of genomic regions influencing the response of ...yield and its components to waterlogging stress will enhance our understanding of the genetics of waterlogging tolerance and the development of more tolerant barley cultivars. Quantitative trait loci （QTLs） for grain yield and its components were identified using 156 doubled haploid （DH） lines derived from a cross between the cultivars Yerong （waterlogging-tolerant） and Franklin （waterlogging-sensitive） grown under different conditions （waterlogged and well drained）. A total of 31 QTLs were identified for the measured characters from two experiments with two growth environments. The phenotypic variation explained by individual QTLs ranged from 4.74% to 55.34%. Several major QTLs determining kernel weight （KW）, grains per spike （GS）, spikes per plant （SP）, spike length （SL） and grain yield （GY） were detected on the same region of chromosome 2H, indicating close linkage or pleiotropy of the gene（s） controlling these traits. Some different QTLs were identified under waterlogging conditions, and thus different markers may have to be used in selecting cultivars suitable for high rainfall areas.
Constructed wetland is a mode of economical and highly effective system applied in wastewater treatment with special removal mechanism function, which has drawn much attention over the world ...constantly. On the basis of study from abroad, this article makes the brief induction of removal mechanism, influential factors and combined technique of constructed wetlands, for the further research works were also put forward in the next future.
Colla corii asini
(Ejiao), a gelatin-like food and drug obtained from
Equus asinus Linnaeus
, has been widely used in clinical hematic antianemic therapy for more than 2000 years. The elucidation of ...the characteristic metabolic alterations achieved during its treatment of anemia is critical to the screening of the biomarkers involved in anemia and improving the understanding of the hematinic effects of Ejiao. This work presents the first
1
H-NMR-based metabolomics coupled with a correlation analysis study of the characteristic metabolic profiles of APH-induced anemic rats subjected to Ejiao treatment. Significant differences in the metabolic profiles of the rats in the control, blood deficiency and treatment groups were observed, and the identified serum biomarkers including arginine, aspartate, choline and dimethylglycine, could be used for the diagnosis of anemia. The results also showed that Ejiao may play a hematinic role through regulating the lipid and lipoprotein metabolism, energy metabolism, gut microflora and amino acid metabolism, reflecting the multi-target therapeutic effect of traditional Chinese medicine, which may be helpful for understanding the hematinic mechanism of Ejiao.
Colla corii asini
(Ejiao), a gelatin-like food and drug obtained from
Equus asinus Linnaeus
, has been widely used in clinical hematic antianemic therapy for more than 2000 years.
Thin-film lithium-ion batteries are the most competitive power sources for various kinds of micro-electro-mechanical systems and have been extensively researched. The present paper reviews the recent ...progress on Sn-based thin-film anode materials, with particular emphasis on the preparation and performances of pure Sn, Sn-based alloy, and Sn-based oxide thin films. From this survey, several conclusions can be drawn concerning the properties of Sn-based thin-film anodes. Pure Sn thin films deliver high reversible capacity but very poor cyclability due to the huge volume changes that accompany lithium insertion/extraction. The cycle performance of Sn-based intermetallic thin films can be enhanced at the expense of their capacities by alloying with inactive transition metals. In contrast to anodes in which Sn is alloyed with inactive transition metals, Sn-based nanocomposite films deliver high capacity with enhanced cycle performance through the incorporation of active elements. In comparison with pure Sn anodes, Sn-based oxide thin films show greatly enhanced cyclability due to the in situ formation of Sn nanodispersoids in an Li₂O matrix, although there is quite a large initial irreversible capacity loss. For all of these anodes, substantial improvements have been achieved by micro-nanostructure tuning of the active materials. Based on the progress that has already been made on the relationship between the properties and microstructures of Sn-based thin-film anodes, it is believed that manipulating the multi-phase and multi-scale structures offers an important means of further improving the capacity and cyclability of Sn-based alloy thin-film anodes.
Background Endogenous hydrogen sulfide （H2S） plays an important role in hypertension. The aim of this study was to investigate the role of erythrocyte and serum H2S in patients with untreated ...essential hypertension. Methods We recruited 62 patients （age 22-74 years） with untreated prehypertension or hypertension, and 64 normotensive subjects （age 18-64 years）. We assessed the 3-mercaptopyruvate sulphurtransferase （MPST） protein expression in erythrocytes and measured the H2S production from erythrocytes and serum H2S levels, then analyzed the association of erythrocytic or serum H2S content and blood pressure or cardiovascular risk factors （e.g., age, body mass index （BMI） and dyslipidemia）. A stepwise regression analysis was used to evaluate the possible relationship of erythrocytic H2S in hypertension. Results In hypertensive patients, erythrocyte H2S production （（111.04_＋.29.20） nmol/min per 10a erythrocytes） was higher than that in controls （（78.85＋19.38） nmol/min per 108 erythrocytes）, and serum H2S was also higher. The erythrocytic H2S production was associated with increased systolic blood pressure （sBP）, diastolic blood pressure （dBP）, age, BMI, level of C-reactive protein （CRP）, as well as triglycerides （TG） and high density lipoprotein cholesterol （HDL-C） Serum H2S was not associated with age or CRP. Stepwise regression analysis showed that erythrocytic H2S production was correlated with sBP, TG, HDL-C, low density lipoprotein cholesterol （LDL-C） and blood urea nitrogen （BUN） and serum H2S was correlated with dBP and TG. Results of receiver-operating characteristic curve analysis suggested that erythrocytic H2S production was a more sensitive predictor of hypertension development than serum H2S. Conclusion Ervthrocvtic or serum H~S Production is sensitive predictor of hvDertension.
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