The synthesis and in vitro cytotoxicity of a series of Pt super(IV) complexes with lonidamine as a ligand coordinated in axial position are described. Lonidamine was found to affect strongly the in ...vitro cytotoxic activity of these new complexes, lowering the IC sub(50) values down to the nanomolar range. Lipophilicity assessed in terms of logP showed no direct correlation with cytotoxicity. A series of Pt super(IV) complexes with lonidamine as a ligand coordinated in axial position is reported. Lonidamine affects strongly the in vitro cytotoxic activity, lowering the IC sub(50) values down to the nanomolar range.
A novel nonimmortalized fibroblast-like cell line SC6-MSC was derived from SC6 human embryonic stem cells (ESCs). Numerical and structural karyotypic analyses of these cells have revealed that it is ...hypodiploid: 45, X0. SC6-MSC average population doubling time was 26.0 ± 0.4 h at the 8th passage and 82.0 ± 9.2 h at the 18th passage. The growth curves showed active proliferation during passages 8–10 and consequent gradual decrease of the proliferative activity that stopped by the 20th passage. Flow cytometry analysis of surface markers has been carried to determine the line status. Revealed positive expression of CD44, CD73, CD90, CD105, and HLA-ABC and lack of CD34 and HLA-DR surface antigens are common for mesenchymal stem cells (MSCs). However, expression of CD90 and CD105 surface markers was significantly lower than for other MSC lines, including the line SC5-MSC derived from human ESC line SC5. Immunofluorescence analysis of surface markers and Oct-4 transcription factor, characteristic for human embryonic stem cells, showed the lack of Oct-4 expression and the presence of SSEA-4 and TRA-1-60 typical for a number of karyotypically normal MSC lines. Immunofluorescence assay showed the presence of the early differentiation markers of three germ layer derivates common for human ESCs. This shows that MSCs may be useful for reparation of tissue damage in corresponding microenvironments. It was revealed that SC6-MSC cells were able to differentiate into osteogenic and chondrogenic, but not adipogenic, directions. The results obtained indicate with high probability that disordered chromosomal and, accordingly, gene balance, in SC6-MSC line with karyotype 45, X0 result in decreased differential potential and expression of CD90 associated with the processes of cell differentiation and aging.
We obtain black hole rotating solutions for Horndesky theory (specific partial case), bumblebee model and Gauss-Bonnet scalar gravity using the specially improved Newman-Janis algorithm. The shadow ...profiles for these metrics were calculated. Applying the limitations from the Event Horizon Telescope we find the opportunity to constrain model parameters from considered extended gravity theories. We show that for three considered models two of them (Horndesky theory and Gauss-Bonnet scalar gravity) weaken the effect of rotation and bumblebee model enhances it. This conclusion matches the previously obtained one that extended gravity theories by themselves correct the effect of rotation in both directions.
Review of Particle Physics Tanabashi, M.; Nakamura, K.; Takahashi, F. ...
Physical review. D,
08/2018, Volume:
98, Issue:
3
Journal Article
Peer reviewed
The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 2,873 new measurements from 758 papers, we list, evaluate, and average measured properties of ...gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. Particle properties and search limits are listed in Summary Tables. We give numerous tables, figures, formulae, and reviews of topics such as Higgs Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology, Particle Detectors, Colliders, Probability and Statistics. Here, among the 118 reviews are many that are new or heavily revised, including a new review on Neutrinos in Cosmology.
The challenges posed by epidemics and pandemics are immense, especially if the causes are novel. This article introduces a versatile open-source simulation framework designed to model intricate ...dynamics of infectious diseases across diverse population centres. Taking inspiration from historical precedents such as the Spanish flu and COVID-19, and geographical economic theories such as Central place theory, the simulation integrates agent-based modelling to depict the movement and interactions of individuals within different settlement hierarchies. Additionally, the framework provides a tool for decision-makers to assess and strategize optimal distribution plans for limited resources like vaccines or cures as well as to impose mobility restrictions.
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