Objectives
Dabigatran is a direct thrombin inhibitor shown to be an effective alternative to warfarin in patients with non-valvular atrial fibrillation (AF). We evaluated the use of dabigatran in ...patients with bioprosthetic mitral and/or aortic valve replacement and AF.
Methods
We selected 34 and randomized 27 patients in a 1:1 ratio to receive dabigatran or warfarin. The primary endpoint was the presence of a new intracardiac thrombus at 90 days, by transesophageal echocardiogram (TEE). Secondary endpoints included the development of dense spontaneous echo contrast (SEC) and incidence of stroke (ischemic or hemorrhagic), myocardium infarction, valve thrombosis and peripheral embolic events.
Results
The trial was terminated prematurely because of low enrollment. There were 27 patients in total: 15 patients placed in the dabigatran group and 12 in the warfarin group. After 90 days, one patient (8.3 %) in the warfarin group and none in the dabigatran group had developed a new intracardiac thrombus. In the dabigatran group, two patients (13.3 %) developed dense SEC versus one patient (8.3 %) in the warfarin group. In the warfarin group, one patient (8.3 %) presented ischemic stroke, and none did in the dabigatran group. We observed no cases of hemorrhagic stroke, valve thrombosis, embolic events or myocardial infarction in either group throughout the study. However, one patient (6.7 %) in the dabigatran group had a fully recovered transient ischemic attack and one patient in the warfarin group died of heart failure.
Conclusions
The use of dabigatran appears to be similar to warfarin in preventing the formation of intracardiac thrombus.
Trial Registration
Clinicaltrials.gov NCT01868243.
Resumo A greve das cigarreiras de 1903 foi encetada pela demissão das primeiras quatro mulheres a ingressarem no movimento operário do Recife. Com o objetivo de compreender as motivações que levaram ...essas trabalhadoras a se organizarem politicamente, este artigo analisa os eventos em torno da greve e as representações sociais que situavam o trabalho de mulheres em fábricas como uma prática moralmente reprovável. O exame das questões propostas evidencia que as cigarreiras se apropriaram das plataformas de ação fornecidas pelo movimento operário para conquistar visibilidade em um processo de estabelecimento de uma identidade de gênero relacionada ao trabalho.
Abstract A 1903 strike of tobacco worker's was triggered by the layoff of the first four women who joined the labor movement in the city of Recife. To understand why these women workers organized politically, the article analyzes events related to the strike and social representations of female work in factories as morally reprehensible. The examination of the questions raised reveals that the tobacco workers appropriated the platforms for action provided by the labor movement to gain visibility in a process of establishing a work-related gender identity.
Multi-walled carbon nanotubes (MWCNT) and powder activated carbon (PAC) were used as adsorbents for adsorption of Direct Blue 53 dye (DB-53) from aqueous solutions. The adsorbents were characterised ...using Raman spectroscopy, N2 adsorption/desorption isotherms, and scanning and transmission electron microscopy. The effects of initial pH, contact time and temperature on adsorption capacity of the adsorbents were investigated. At pH 2.0, optimum adsorption of the dye was achieved by both adsorbents. Equilibrium contact times of 3 and 4 h were achieved by MWCNT and PAC adsorbents, respectively. The general order kinetic model provided the best fit of the experimental data compared to pseudo-first order and pseudo-second order kinetic adsorption models. For DB-53 dye, the equilibrium data (298–323 K) were best fitted to the Sips isotherm model. The maximum sorption capacity for adsorption of the dye occurred at 323 K, with the values of 409.4 and 135.2 mg g−1 for MWCNT and PAC, respectively. Studies of adsorption/desorption were conducted and the results showed that DB-53 loaded MWCNT could be regenerated (97.85%) using a mixture 50% acetone + 50% of 3 mol L−1 NaOH. Simulated dye house effluents were used to evaluate the application of the adsorbents for effluent treatment (removal of 99.87% and 97.00% for MWCNT and PAC, respectively, were recorded).
•Adsorption of DB-53 dye was studied using MWCNT and CAC as adsorbents.•MWCNT was characterised using Raman spectroscopy, SEM and TEM techniques.•Maximum adsorption capacities of MWCNT and CAC are 409.4 and 135.2 mg/g, respectively.•The adsorption processes are well described by general order kinetic model.•MWCNT and CAC have been proven effective for removal of DB-53 dye.
One of the biggest challenges involving low-cost inertial and magnetic sensors, especially the latter, is the inherent distortion/corruption of their measurements by systematic errors. Such errors ...can be so compromising that using the corrupted measurements for navigation purposes becomes an impossible task. In addition to sensor fusion, which aims at improving performance, calibration techniques can precisely estimate these errors, which, then, can be compensated for. This article revisits the problem of in-field magnetometer calibration, focusing on the traditional and well-established ellipsoid fitting-based extended two-step (ETS) method. Despite being largely employed, especially for initializing more sophisticated and iterative optimization-based calibration techniques, ETS implementation is not straightforward, as the mapping between its estimated intermediate parameters and the sensor error parameters of interest (biases, scale factors, and misalignments) has not been clearly provided in the literature yet. In this article, hence, we carefully derive the latter, aiming at facilitating ETS numerical implementation. Withal, and also figuring as main contribution of this article, we provide analytical closed-form solutions for ETS, which are especially suitable for low-cost, real-time embedded applications. In order to validate their accuracy, insensitivity to local-minima convergence issues, and computational efficiency, we present simulations—including a Monte Carlo analysis—and hardware implementation, alongside a comprehensive comparison with state-of-the-art magnetometer calibration techniques.
The present investigation describes the preparation of a sodium niobate nanostructured material and the application of it as catalyst in condensation reactions. Well-defined NaNbO
3
nanoplates were ...obtained via a basic hydrothermal process using Nb
2
O
5
·nH
2
O as starting material. The NaNbO
3
nanostructured catalyst was characterized by scanning electron microscopy (SEM) and X-ray diffractometry (XRD), N
2
adsorption/desorption isotherms, and hydrogen temperature-programmed reduction (H
2
-TPR) analysis. The performance of NaNbO
3
as a catalyst was evaluated in condensation reactions for the preparation of 2-arylidene indan-1,3-diones, C-3 functionalized isobenzofuran-1(3
H
)-ones, Meldrum’s acid derivatives, and a coumarin. The products obtained in these reactions present several important bioactivities and are useful building blocks in organic synthesis. The condensation reactions were run under microwave irradiation and without the use of solvents. The compounds prepared in the condensation reactions were purified by recrystallization and obtained with satisfactory yields and short reaction times. The catalyst can be recycled in the condensation processes.
Durante quase meio século, entre 1881 e 1930, o Brasil registrou seus menores índices de participação eleitoral desde a independência até os dias atuais. O presente artigo evidencia que esses índices ...não eram consequência apenas das cláusulas constitucionais que excluíam do direito de voto mulheres e analfabetos. Ao longo do período enfocado o parlamento brasileiro atuou como uma barreira de contenção, promulgando reformas eleitorais ordinárias que dificultavam o alistamento de cidadãos que, em teoria, poderiam gozar dos direitos políticos. Essas reformas eram decretadas em momentos de expansão do eleitorado e acabavam por estancar pequenos ciclos de aumento da franquia eleitoral. As dificuldades de acesso aos direitos políticos criadas por meio desses mecanismos atingiram principalmente os mais pobres e os egressos da escravidão, os impactos dessas reformas no corpo do eleitorado serão demonstrados ao longo do texto.
Objetivou-se com esse trabalho verificar a capacidade de hortaliças não convencionais em acumular silício, bem como a resposta destas à adubação silicatada. O experimento foi conduzido em casa de ...vegetação em 2016. Foram avaliados duas doses de adubação silicatada (0 e 50 mg dm-3 de Si), e nove espécies de hortaliças não convencionais (Maranta arundinacea L., Rumex acetosa L., Amaranthus spinosus L., Amaranthus viridis L., Amaranthus retroflexus L., Amaranthus deflexus L., Amaranthus hybridus L., Stachys byzantina K. Koch e Sonchus oleraceus L.), dispostos em delineamento inteiramente casualizado em esquema fatorial 2 x 9, com quatro repetições. Foram determinadas a massas fresca e seca, assim como o teor de Si em todas as plantas. As espécies avaliadas possuem potencial para acumular silício mediante adubação com o elemento. A aplicação de 50 mg dm-3 de Si proporcionou maior teor de Si nas espécies estudadas. A adubação com Si, de modo geral, não influencia na biomassa dessas plantas.
RESUMO Huguenotes, ingleses e abacaxis são termos que foram empregados por abolicionistas para ocultar a identidade de pessoas escravizadas que escaparam do cativeiro por rotas de fuga entre a Zona ...da Mata pernambucana, o Recife e os quilombos abolicionistas no Ceará. O artigo aborda a montagem de uma rede abolicionista interprovincial no início da década de 1880 e a intensificação das fugas de escravizados entre 1884 e 1888, observando em particular a atuação clandestina e radical do Clube do Cupim, bem como alguns aspectos relacionados à construção de sua memória no pós-abolição. O Clube se destacou em relação às associações abolicionistas do período pela diversidade social de seus membros e pela capacidade de promover a articulação de trabalhadores livres pobres, libertos e escravizados em operações que desarticularam o escravismo na região.
ABSTRACT Using terms like Huguenots, Englishmen, and pineapples, abolitionists have concealed the identity of enslaved people that they were in escape routes across the Pernambuco’s Zona da Mata region, Recife, and abolitionist quilombos in Ceará. This article examines the emergence of an interprovincial abolitionist networking in the early 1880s and the growing movement of escaped slaves between 1884 and 1888. It focuses on clandestine and radical actions performed by the Clube do Cupim. It also takes into consideration some aspects of Clube’s memory in the post-abolition. The Club stood out amongst abolitionist associations in terms of social diversity and the capacity to engage free, liberated and enslaved workers in operations that caused impacts over slavery in the region.
RESUMEN Hugonotes, inglés y piñas son términos que fueron utilizados por los abolicionistas para ocultar la identidad de las personas esclavizadas que escaparon del cautiverio a través de rutas de escape entre la Zona da Mata de Pernambuco, Recife y los quilombos abolicionistas en Ceará. El artículo analiza la instalación de una red abolicionista interprovincial a principios de la década de 1880 y la intensificación de la fuga de personas esclavizadas entre 1884 y 1888, destacando en particular las actividades clandestinas y radicales del Clube do Cupim, así como algunos aspectos relacionados con la construcción de su memoria post-abolición. El Club se destacó en relación a las asociaciones abolicionistas de la época por la diversidad social de sus miembros y por su capacidad de promover la articulación de los trabajadores libres pobres, libres y esclavizados en operaciones de desmantelamiento de la esclavitud en la región.
The objective of this study was to characterize the nutritional compounds of interest present in vegetables known as non-conventional, in Brazil. The following evaluations were carried out: ...antioxidant activity, phenolic compounds, vitamin C, calories, carbohydrates, humidity, lipids, proteins, fiber, acidity and quantification of minerals (P, K, Ca, Mg, S, Cu, Fe, Mn, Zn and B). The species studied were Amaranthus hybridus L., Amaranthus viridis L., Basella alba L., Eryngium campestre L., Hibiscus sabdariffa L., Lactuca canadensis L., Rumex acetosa L., Stachys byzantina K. Koch, Tropaeolum majus L. and Xanthosoma sagittifolium L. Representative samples of plant structures of interest were harvested from each species suitable for human consumption such as leaves, flowers and flower buds. The results were submitted to multivariate analysis - principal components analysis (PCA). All the species present nutritional compounds of interest in different levels among the evaluated structures.
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► Mango seed used in its natural and protonated form as biosorbents. ► Characterization of biosorbents by FTIR, SEM, BET and BJH techniques. ► A new general order kinetic equation ...developed to fit the experimental results. ► Mechanism of adsorption evaluated using computational simulation. ► Water plays important role in the interaction between dye and biosorbent.
Mango seed, an abundant residue of the food industry, was used in its natural form (MS) and protonated form (AMS) as a biosorbent for the removal of Victazol Orange 3R (VO-3R) dye from its aqueous solutions. These biosorbents were characterized by infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and by nitrogen adsorption/desorption curves. Optimization of the effects of the initial pH of the dye solution, biosorbent dosage and contact time between the dye and the biosorbents on the biosorption capacities of the biosorbents was studied. Based on an error function (Ferror), the general order kinetic model provided the best fit to the experimental data when compared to the pseudo-first order and pseudo-second order kinetic biosorption models. The equilibrium data were fitted to Langmuir, Freundlich and Liu isotherm models. For both biosorbents, the equilibrium data were best fitted to the Liu isotherm model. Finally, the mechanism of biosorption involving VO-3R and lignin–cellulose was evaluated using the hybrid quantum mechanical/molecular mechanical (QM/MM) approach and molecular dynamic (MD) simulations. The results suggest that water molecules play a key role in the biosorption process.
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