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  • CHO cells in biotechnology ... CHO cells in biotechnology for production of recombinant proteins: current state and further potential
    Kim, Jee Yon; Kim, Yeon-Gu; Lee, Gyun Min Applied microbiology and biotechnology, 02/2012, Volume: 93, Issue: 3
    Journal Article
    Peer reviewed

    Recombinant Chinese hamster ovary cells (rCHO) cells have been the most commonly used mammalian host for large-scale commercial production of therapeutic proteins. Recent advances in cell culture ...
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  • Random epigenetic modulatio... Random epigenetic modulation of CHO cells by repeated knockdown of DNA methyltransferases increases population diversity and enables sorting of cells with higher production capacities
    Weinguny, Marcus; Eisenhut, Peter; Klanert, Gerald ... Biotechnology and bioengineering, November 2020, Volume: 117, Issue: 11
    Journal Article
    Peer reviewed
    Open access

    Chinese hamster ovary (CHO) cells produce a large share of today's biopharmaceuticals. Still, the generation of satisfactory producer cell lines is a tedious undertaking. Recently, it was found that ...
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  • Metabolic signatures of GS-... Metabolic signatures of GS-CHO cell clones associated with butyrate treatment and culture phase transition
    Carinhas, Nuno; Duarte, Tiago M.; Barreiro, Laura C. ... Biotechnology and bioengineering, December 2013, Volume: 110, Issue: 12
    Journal Article
    Peer reviewed

    ABSTRACT Chinese hamster ovary (CHO) cells are preferred hosts for the production of recombinant biopharmaceuticals. Efforts to optimize these bioprocesses have largely relied on empirical experience ...
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  • Intracellular response to p... Intracellular response to process optimization and impact on productivity and product aggregates for a high‐titer CHO cell process
    Handlogten, Michael W.; Lee‐O'Brien, Allison; Roy, Gargi ... Biotechnology and bioengineering, January 2018, Volume: 115, Issue: 1
    Journal Article
    Peer reviewed

    A key goal in process development for antibodies is to increase productivity while maintaining or improving product quality. During process development of an antibody, titers were increased from 4 to ...
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  • Cell‐controlled hybrid perf... Cell‐controlled hybrid perfusion fed‐batch CHO cell process provides significant productivity improvement over conventional fed‐batch cultures
    Hiller, Gregory W.; Ovalle, Ana Maria; Gagnon, Matthew P. ... Biotechnology and bioengineering, July 2017, Volume: 114, Issue: 7
    Journal Article
    Peer reviewed

    ABSTRACT A simple method originally designed to control lactate accumulation in fed‐batch cultures of Chinese Hamster Ovary (CHO) cells has been modified and extended to allow cells in culture to ...
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  • The genomic sequence of the... The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line
    Xu, Xun; Nagarajan, Harish; Lewis, Nathan E ... Nature biotechnology, 08/2011, Volume: 29, Issue: 8
    Journal Article
    Peer reviewed
    Open access

    Chinese hamster ovary (CHO)-derived cell lines are the preferred host cells for the production of therapeutic proteins. Here we present a draft genomic sequence of the CHO-K1 ancestral cell line. The ...
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  • The art of CHO cell enginee... The art of CHO cell engineering: A comprehensive retrospect and future perspectives
    Fischer, Simon; Handrick, René; Otte, Kerstin Biotechnology advances, 12/2015, Volume: 33, Issue: 8
    Journal Article
    Peer reviewed

    Chinese hamster ovary (CHO) cells represent the most frequently applied host cell system for industrial manufacturing of recombinant protein therapeutics. CHO cells are capable of producing high ...
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  • Improving the secretory cap... Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
    Hansen, Henning Gram; Pristovšek, Nuša; Kildegaard, Helene Faustrup ... Biotechnology advances, 2017 Jan - Feb, 2017-01-00, 20170101, Volume: 35, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Chinese hamster ovary (CHO) cells are the preferred cell factory for the production of therapeutic glycoproteins. Although efforts primarily within bioprocess optimization have led to increased ...
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  • The AAV9 receptor and its m... The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice
    Bell, Christie L; Vandenberghe, Luk H; Bell, Peter ... The Journal of clinical investigation, 06/2011, Volume: 121, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    Vectors based on adeno-associated virus (AAV) serotype 9 are candidates for in vivo gene delivery to many organs, but the receptor(s) mediating these tropisms have yet to be defined. We evaluated ...
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  • Mapping the molecular basis... Mapping the molecular basis for growth related phenotypes in industrial producer CHO cell lines using differential proteomic analysis
    Bryan, Laura; Henry, Michael; Kelly, Ronan M ... BMC biotechnology, 07/2021, Volume: 21, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    The ability to achieve high peak viable cell density earlier in CHO cell culture and maintain an extended cell viability throughout the production process is highly desirable to increase recombinant ...
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