Lactate dehydrogenase (LDH) among many biochemical parameters represents a very valuable enzyme in patients with cancer with possibility for easy routine measurement in many clinical laboratories. ...Previous studies where mostly based on investigated LDH in serum of patients with cancer with aims to estimate their clinical significance. The new directions in investigation of LDH where based on the principle that tumor cells release intracellular enzymes trough damaged cell membrane, that is mostly consequence in intracellular mitochondrial machinery alteration, and apoptosis deregulation. This consideration can be used not only in-vitro assays, but also in respect to clinical characteristics of tumor patients. Based on new techniques of molecular biology it is shown that intracellular characteristics of LDH enzyme are very sensitive indicators of the cellular metabolic state, aerobic or anaerobic direction of glycolysis, activation status and malignant transformation. Using different molecular analyses it is very useful to analyzed intracellular LDH activity in different cell line and tumor tissues obtained from patients, not only to understanding complexity in cancer biochemistry but also in early clinical diagnosis. Based on understandings of the LDH altered metabolism, new therapy option is created with aims to blocking certain metabolic pathways and stop tumors growth.
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•MgCo2O4@NiMn-LDH core-shell nanoarrays is fabricated on Ni foams.•The materials are obtained by a facile hydrothermal strategy.•MgCo2O4@NiMn-LDH electrode exhibits superb ...supercapacitive performance.
In this work, MgCo2O4@NiMn layered double hydroxide (LDH) core-shell structured nanocomposites on Ni foam (NF) are synthesized by facile hydrothermal and calcination methods. MgCo2O4/NF is synthesized first via a hydrothermal reaction and annealing treatment, and then utilized to prepare MgCo2O4@NiMn-LDH/NF core-shell structured nanocomposites via the second hydrothermal process. It is found that the MgCo2O4@NiMn-LDH/NF nanocomposite prepared from 6 h hydrothermal reaction (MC@NM-LDH-2) exhibits an excellent specific capacitance of 3757.2 F g−1 (at 1 A g−1). Moreover, a high capacitance retention (86.9% after 6000 cycles) and a low internal resistance (Rs) (0.565 Ω) can be achieved. Furthermore, an all-solid-state asymmetric supercapacitor (ASC) is assembled using MgCo2O4@NiMn-LDH/NF-2 as positive electrode and activated carbon (AC) as negative electrode. The as-fabricated MgCo2O4@NiMn-LDH/NF-2//AC ASC shows a high energy density of 62.33 Wh kg−1 at 750 W kg−1. Meanwhile, the MgCo2O4@NiMn-LDH/NF-2//AC ASC device possesses an outstanding cycling stability of 93.7% retention of the initial capacitance after 6000 cycles and three ASC devices connected in series can light up a LED bulb for 15 min. Our results manifest that these core-shell structure MgCo2O4@NiMn-LDH nanocomposites could envision huge potential application in energy storage devices.
AML is a heterogeneous clonal neoplasm. The most common prognostic risk factors for AML are cytogenetic abnormalities and environmental risk factors. Pathological indicators of high tumor burden and ...poor prognosis include high white blood cell (WBC) count and lactate dehydrogenase (LDH) level.
The current study intended to determine the clinical significance and prognostic value of serum LDH levels in AML patients.
This is a retrospective single-center study of 40 (M, 19; F: 21) AML patients at the Hematology Unit, Oncology Center Mansoura University (OCMU).
The mean age ±SD was 44.3±15.1 years. Median WBC count was 31.5×109/L; median hemoglobin (Hb) concentration was 8.5 g/dL; and median platelet count was 32.2×109/L. Median serum LDH was 731.5 IU/L (range 188-6292).
Patients received standard-intensity induction chemotherapy (7+3), followed by consolidation with high-dose cytarabine for patients in complete remission.
Elevated WBC counts and LDH levels were associated with shorter overall survival (OS) in univariable analysis. In multivariable analysis, higher LDH levels were a poor prognostic factor for prediction of shorter OS among studied AML patients (P=0.018; HR=1.012, 95% CI, 1.005-1.071).
LDH levels were significantly higher in AML patients than healthy controls (214 IU/L, range 107-330) (P<0.001). LDH levels showed significant positive correlation with WBC count, while no significant correlations were found between LDH levels and age, Hb concentration or platelet counts. Higher LDH levels were significantly associated with patients’ age above 60 years and WBC counts >50×109/L (P<0.05). There were no significant differences between LDH levels and stratified risk groups, response to treatment or mortality (P>0.05). AML patients with LDH levels above the median value had significantly shorter OS (median OS 95% CI, 2 months; range 1-6 months) compared to AML patients with lower LDH levels (median OS 95% CI, 6 months; range 1-9 months) (P 0.035).
Evaluation of LDH serum levels at diagnosis is an easy and inexpensive test. We conclude that high serum LDH levels in newly diagnosed AML patients should be considered a poor prognostic factor in regards to survival outcomes.
•The removal ratio of phosphate onto Zn–Al LDH was higher than Mg–Al LDH and reached 95% respectively.•Mg–Al and Zn–Al LDHs exhibited rapid adsorption rates of phosphate and could reach equilibrium ...at 40min.•Phosphate species are adsorbed by LDHs via electrostatic attraction, ligand exchange and ion exchange.
Phosphate removal is important for the natural water or wastewater treatment, and adsorption is an efficient treatment process. In this study, Mg–Al and Zn–Al layered double hydroxides (LDHs) were synthesized by co-precipitation method at a constant pH of 9–10. The prepared LDHs were characterized by X-ray diffraction (XRD) and BET surface area determination. The XRD patterns showed the characteristic basal reflections of hydrotalcite-like LDH materials. BET surface area of Zn–Al LDH was larger than that of Mg–Al LDH. Adsorption experiments were carried out as a function of LDHs dosage, contact time and initial pH of phosphate solution. The adsorption of phosphate reached equilibrium quickly at about 40min. The experimental data showed a good compliance with the pseudo-second-order kinetic model. The Freundlich and Langmuir models both described the adsorption isotherm data well (R2>0.98). Zeta potential and fourier transform infrared spectroscopy (FTIR) analyses were used to elucidate adsorption mechanisms. The results indicated that phosphate species were adsorbed via electrostatic attraction, ligand exchange and ion exchange. The removal ratio of phosphate onto Zn–Al LDH was higher than Mg–Al LDH and reached 95% respectively, suggesting that Mg–Al and Zn–Al LDHs were excellent adsorbents for phosphorus removal from aqueous solution.
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•NiFe-LDH/Ni(OH)2 composite electrocatalyst was prepared by two-steps electrodeposition.•The HER maximum current density of NiFe-LDH/Ni(OH)2 composite three times higher than ...NiFe-LDH.•NiFe-LDH/Ni(OH)2 can act as bifunctional electrocatalyst for hydrogen and oxygen evolutions.•The cell voltages to reach current densities of 10 mA/cm2 during water splitting process is 1.6 V.•Ni(OH)2 accelerate the water dissociation and electron transfer.
NiFe-layer double hydroxide (NiFe-LDH) has been widely explored for oxygen evolution reaction (OER), but only a few works have been done for hydrogen evolution reaction (HER). Herein, NiFe-LDH is activated for HER and overall water splitting by depositing Ni(OH)2 nanoparticle to form NiFe-LDH/Ni(OH)2 composite electrocatalyst using two-step electrodeposition method. The electrocatalytic performance of NiFe-LDH/Ni(OH)2 in alkaline condition greatly improves as compared to that with single-phase NiFe-LDH or Ni(OH)2. At a higher overpotential of − 0.3 V, NiFe-LDH/Ni(OH)2 composite could reach a current density of 180 mA/cm2 which increases 3-fold as compared to a single-phase NiFe-LDH (60 mA/ cm2). More importantly, NiFe-LDH/Ni(OH)2 composite can act as a bifunctional electrocatalyst for overall water splitting. The cell voltages at current densities of 10 and 100 mA/cm2 are 1.6 and 1.8 VRHE, respectively during the water splitting process. The great improvement of electrocatalytic activities after the formation of composite catalysts is due to the synergetic effect between NiFe-LDH and Ni(OH)2 to efficiently accelerate the water dissociation step and electron transfer through Ni(OH)2 layer. This work provides simple and robust electrodeposition technique to prepare NiFe-LDH/Ni(OH)2 composite for activating HER and overall water splitting.
In this work, hierarchical MgCo2O4@CoFe layered double hydroxide (LDH) core-shell nanowire arrays on Ni foam (NF) are synthesized by facile hydrothermal and calcination methods. MgCo2O4/NF has been ...first synthesized via a hydrothermal reaction and annealing treatment and then utilized to prepare MgCo2O4@CoFe-LDH/NF core-shell nanocomposites via the second hydrothermal reaction. It is found that the MgCo2O4@CoFe-LDH/NF core-shell nanocomposite prepared from 3 h hydrothermal reaction (MC@CF-LDH-3) exhibits an excellent specific capacitance of 903.15 C g−1 (2007 F g−1) at the current density of 1 A g−1. Moreover, a high capacitance retention (80.2% maintained after 5000 cycles) and a low internal resistance (Rs) (0.75 Ω) can be acquired. Furthermore, an all-solid-state asymmetric supercapacitor (ASC) is assembled using MgCo2O4@CoFe-LDH/NF-3 as the positive electrode and activated carbon (AC) as the negative electrode. The as-fabricated MgCo2O4@CoFe-LDH/NF-3//AC ASC shows a high energy density of 60.82 Wh kg−1 at 725 W kg−1. Meanwhile, the MgCo2O4@CoFe-LDH/NF-3//AC ASC device possesses an excellent cycling stability of 93.6% retention of the initial capacitance after 5000 cycles and two ASC devices connected in series can light up a LED bulb for 8 min. Our results manifest that this hierarchical MgCo2O4@CoFe-LDH composite has huge potential application in energy storage devices.
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•MgCo2O4@CoFe-LDH core-shell nanoarrays is fabricated on Ni foams.•The materials are obtained by a facile hydrothermal strategy.•MgCo2O4@CoFe-LDH electrode exhibits superb supercapacitive performance.
Layered double hydroxides (LDHs) have received great attention for years in numerous fields. Controlled and flexible layer composition, as well as the vast assortment of possible anionic guests, and ...easy adaptability for multipurpose applications, have been some of the many reasons behind their extraordinary success. However, versatility does not only involve the composition or the dimensions of the crystals but also their morphology. Aside from conventional hexagonal, flat structures, three-dimensional assemblies have been reported with architectures closely resembling those of flowers. The possibility of interconnecting the LDH nanosheets in rosette-like geometries has arisen the interest in finding new ways to control, modulate, and guide the particle growth obtaining hierarchical structures to be adapted to specific targets. This review is focused on describing the different strategies implemented to build flower-like assemblies, and on investigating their applications, looking for specific advantages of the use of a three-dimensional architecture over a bi-dimensional one.
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•Insights on the conditions influencing the morphology of layered double hydroxides.•Description of multiple synthetic strategies to obtain three-dimensional, flower-like LDHs.•Comparison between the efficiency of bidimensional and three dimensional LDH particles on different fields of application.•Potential future applications of LDHs with flower-like geometry.
•Calcined CoFe-LDH/g-C3N4 exhibited saturation magnetization.•Calcined CoFe-LDH/g-C3N4 has good adsorption capacity and photocatalytic property.•Cr (VI) was removed via the synergistic effect of ...adsorption and photocatalysis.•Calcined CoFe-LDH/g-C3N4 was recycled for 10 runs with little activity loss.
Magnetic and recyclable calcined CoFe-LDH/g-C3N4 catalyst was prepared by co-precipitation and calcination method, and used as a multifunctional material to remove hexavalent chromium (VI) via the synergistic effect of adsorption and photocatalysis. The calcined CoFe-LDH provide surface adsorption in the composite, which could lead to the adsorption of Cr (VI) with high adsorption capacity and fast speed. The g-C3N4 nanosheets have high photocatalytic activity in situ for the composite to reduce Cr (VI) into Cr (III). The results demonstrated that 60% Cr (VI) (50 mg L−1) can be adsorbed by the nanocomposite in 10 min and the removal efficiency of Cr (VI) reached 100% in 90 min under visible light irradiation by adsorption and photocatalysis. In addition, the calcined CoFe-LDH/g-C3N4 exhibits a mostly pore size about 2.58 nm, large specific surface area (101.61 m2 g−1) with the high structural stability and saturation magnetization (23.06 emu g−1), hence, could be easily recycled for ten subsequent runs with little activity loss.
A hierarchical structure electrode material composed of MgCo2O4 nanowire loaded NiCo-LDH nanosheets shows excellent capacitance and stability and superb energy density. Impressively, two ...MgCo2O4@NiCo-LDH/NF-2//AC asymmetric supercapacitor devices connected in series can light up the LED indicators for up to 15 min, showing a broad practical application prospect.
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•MgCo2O4@NiCo layered double hydroxide (LDH) hierarchical structure nanocomposites is fabricated on 3D Ni foams.•The materials are obtained by a facile hydrothermal strategy.•MgCo2O4@NiCo-LDH electrode exhibits superb supercapacitive performance.
In this work, MgCo2O4@NiCo layered double hydroxide (LDH) hierarchical structure nanocomposites on Ni foam (NF) are synthesized by facile hydrothermal and calcination methods. MgCo2O4/NF is synthesized first via a hydrothermal reaction and annealing treatment and then utilized to prepare MgCo2O4@NiCo-LDH/NF hierarchical structure nanocomposites via the second hydrothermal process. It is found that the MgCo2O4@NiCo-LDH/NF nanocomposite prepared from 9 h hydrothermal reaction (MC@NC-LDH-2) exhibits an excellent specific capacitance of 5701.2 F g−1 at the current density of 1 A g−1. Moreover, a high capacitance retention (83.7% maintained after 5000 cycles) and a low internal resistance (Rs) (0.783 Ω) can be achieved. Furthermore, a quasi-solid state asymmetric supercapacitor (ASC) is assembled using MgCo2O4@NiCo-LDH/NF-2 as positive electrode and activated carbon (AC) as negative electrode. The as-fabricated MgCo2O4@NiCo-LDH/NF-2//AC ASC shows a high energy density of 89.79 Wh kg−1 at 800 W kg−1. Meanwhile, the MgCo2O4@NiCo-LDH/NF-2//AC ASC device possesses an excellent cycling stability of 89.03% retention of the initial capacitance after 5000 cycles and two ASC devices connected in series can light up a LED bulb for 15 min. Our results manifest that these hierarchical MgCo2O4@NiCo-LDH composites could envision huge potential application in energy storage devices.
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•Fine combination of structurally ordered metallic nodes with coordinated unsaturated sites.•Surficial induced growth of ZIF-8 on Zn-layered double hydroxide.•The superior activity ...attributed to metal nodes and accessible coordinately unsaturated sites.•The maximum adsorption capacities were obtained 194.5 mg g−1 For MG and 609.7 mg g−1 for MO.
The current research focus is to develop some systematic materials for the removal of hazardous dyes from water to save the aquatic environment. We have reported the in-situ growth of zeolitic imidazolate frameworks (ZIF-8) on zinc layered double hydroxide (ZnAl-LDH) and the developed porous composite material (ZIF-8@ZnAl-LDH) for adsorptive elimination of malachite green (MG) and methyl orange (MO) from water. The adsorption parameters and organic dyes removal efficiency of ZnAl-LDH, ZIF-8 and ZIF-8@ZnAl-LDH has been determined by considering factors such as dye concentration, time for adsorption and pH of dye solutions. Results showed that ZIF-8@ZnAl-LDH has good adsorption capacity (qmax, 194.5 mg. g−1) for MG as compared to ZnAl-LDH (60.6 mg. g−1) and ZIF-8 (155.27 mg. g−1). Furthermore, ZIF-8@ZnAl-LDH also showed good adsorption capacity (qmax, 609.7 mg. g−1) for methyl orange better than that of ZnAl-LDH (86.35 mg. g−1) and ZIF-8 (322.58 mg. g−1). Also, with 180 min contact time 98% MG and 96.9% MO was adsorbed by ZIF-8@ZnAl-LDH. The Langmuir adsorption isotherm model successfully clarified the process of adsorption as monolayer, with relatively high correlation coefficient of (R2 = 0.9988 of ZIF-8 and 0.9992 of ZIF-8@ZnAl-LDH) for MG and (R2 = 0.9973 of ZIF-8 and 0.9990 of ZIF-8@ZnAl-LDH) for MO. After four consecutive cycles ZIF-8@ZnAl-LDH exhibit 96.27% and 95.16% adsorption for malachite green and methyl orange respectively, of the original capacity of pristine ZIF-8@ZnAl-LDH. The best performance of adsorbents is due to the porous structure, greater superficial area for adsorption process and specific morphological inter-layered structure with exposed metallic nodes. The overall results indicate that the as-synthesized ZIF-8 and its composite ZIF-8@ZnAl-LDH are proficient for purification of water by removing dyes such as (MG & MO) from aqueous solutions.
