Significant progress has been made in prospectively designing molecules using the central nervous system multiparameter optimization (CNS MPO) desirability tool, as evidenced by the analysis reported ...herein of a second wave of drug candidates that originated after the development and implementation of this tool. This simple-to-use design algorithm has expanded design space for CNS candidates and has further demonstrated the advantages of utilizing a flexible, multiparameter approach in drug discovery rather than individual parameters and hard cutoffs of physicochemical properties. The CNS MPO tool has helped to increase the percentage of compounds nominated for clinical development that exhibit alignment of ADME attributes, cross the blood–brain barrier, and reside in lower-risk safety space (low ClogP and high TPSA). The use of this tool has played a role in reducing the number of compounds submitted to exploratory toxicity studies and increasing the survival of our drug candidates through regulatory toxicology into First in Human studies. Overall, the CNS MPO algorithm has helped to improve the prioritization of design ideas and the quality of the compounds nominated for clinical development.
La Revista de Gastroenterología de México (RGM) fundada en 1935 es una de las revistas de divulgación científica en México y Latinoamérica con mayor impacto. El objetivo del presente estudio es ...caracterizar los artículos más citados de la RGM incluyendo originales, revisión y consensos.
Se utilizaron las bases de datos de Scopus, PubMed y Google Scholar para identificar los artículos originales, revisión y consensos más citados de la RGM. Se analizaron sus características como diseño y tema, así como autores e instituciones participantes.
Los artículos más citados de la RGM corresponden al periodo entre 1996 y 2018, teniendo un promedio de 16.5 citas por artículo. El 58% (n = 29) de los trabajos pertenecen al área de gastroenterología y 20% (n = 10) a cirugía; los temas más frecuentes fueron: trastorno funcional digestivo, virus de hepatitis y cáncer gástrico. El 36% de los trabajos corresponden a un diseño prospectivo no aleatorizado, seguido de estudios transversales en el 26% y prospectivos aleatorizados en el 18%.
Los 50 artículos más citados representan un total de 826 citas, mientras que los 10 consensos y artículos de revisión más citados, 208 citas.
Estos trabajos presentan una diversidad en disciplinas afines a la gastroenterología que han logrado impactar en la comunidad científica y representan diferentes grupos de investigación activos a lo largo de la república mexicana y otros países.
The Revista de Gastroenterología de México (RGM), founded in 1935, is one of the most influential journals of scientific dissemination in Mexico and Latin America. The aim of the present review was to characterize the RGM's most frequently cited original articles, review articles, and consensuses.
The most cited original articles, review articles, and consensuses of the RGM were identified using the Scopus, PubMed, and Google Scholar databases. Their designs and topics, as well as their authors and participating institutions, were analyzed.
The most highly cited articles of the RGM corresponded to the period from 1996 to 2018, with a mean of 16.5 citations per article. Fifty-eight percent (n = 29) of the articles belonged to the area of gastroenterology and 20% (n = 10) to surgery. The most frequent topics were functional gastrointestinal disorders, hepatitis virus, and gastric cancer. Thirty-six percent of the articles had a nonrandomized prospective design, followed by cross-sectional studies (26%) and randomized prospective studies (18%).
The 50 most-cited articles included a total of 826 citations and the 10 most-cited consensuses and review articles had a total of 208 citations.
Those studies encompass a diversity of disciplines related to gastroenterology that have impacted the scientific community and correspond to the work of different active research groups in Mexico and other countries.
The monotypic genus Bovitrigla established by Fowler in 1938 accommodates B. acanthomoplate and is known from the Philippines and the South China Sea. A single specimen of B. acanthomoplate was ...collected from the Enshu-nada Sea off Shizuoka Prefecture, Japan. The species is characterized by having a long rostral spine, a long posttemporal spine and a postocular spine, which are the generic diagnostic characters. This record represents not only the first record from Japan but the northernmost record of this species. Comparing the Japanese specimen with ten specimens of this species collected from the South China Sea, we found the former differs in having the following characters: 52 lateral line scales vs. 54–57; snout length 47.5 % in HL vs. 42.5–46.4 %; and interorbital width 33.8 % in HL vs. 29.7–32.7 %. We redescribe this species in detail and give the new standard Japanese name, Minami-sokohobo for this species and Minami-sokohobo-zoku for the genus.
El presente artículo aborda la protección de las personas mayores a la luz de los perfiles evolutivos del sistema europeo de derechos humanos. En efecto, desde una perspectiva de tutela multinivel de ...los derechos humanos, se analizan los estándares del Consejo de Europa y de la Unión, poniendo el acento en la Carta Social Europea y en la jurisprudencia del Comité Europeo de Derechos Sociales. Dicho análisis conduce a concluir que se está forjando un acervo europeo del Ius Senectutis de crucial importancia en el contexto de crisis sanitaria y humanitaria provocada por la pandemia de covid-19. Esos estándares europeos y sus sinergias con otros estándares internacionales y nacionales, en última instancia, están llamados a optimizar los derechos de las personas mayores y su dignidad en coherencia con el principio pro personae.
The function of a steel open-type dam is to trap debris flow. To fulfill this function, the member spacing of a permeable steel open-type dam should be set to one to two times the maximum or the most ...boulder diameter. The maximum or the most boulder diameter is determined by cumulative curve using the boulder that have the potential to become debris flow from that location, with the 95th percentile boulder diameter being the maximum boulder diameter and the maximum value in the most boulder diameter zone being the most boulder diameter. In this survey, 200 boulders are selected by the measurer from the available boulder in the field. For this reason, arbitrariness cannot be completely excluded from the fact that the measurer arbitrarily selects boulder. This means that the boulder diameter distribution obtained by the boulder diameter survey is different from the actual boulder diameter distribution. We investigated the distribution of boulder diameter close to the total number using UAV so as not to omit the boulder that was previously omitted by the measurer. As a result, it was confirmed that the maximum and most boulder diameter obtained by the random method contributed to the blockage of the member spacing at the opening of the permeable steel open-type dam.
TU43; 针对基本灰狼算法存在初始种群不均匀、早熟收敛等问题,基于混沌理论从三个方面对灰狼优化(grey wolf optimization,GWO)算法进行改进,提出了混沌灰狼优化(chaotic grey wolf ...optimization,CGWO)算法用于确定边坡的最小安全系数.首先,采用改进Tent混沌映射提高初始种群多样性;其次,通过混沌扰动策略避免算法陷入局部最优;最后,引入参数混沌非线性调节机制均衡算法的全局开发和局部勘探算力.13个基准测试函数的仿真结果表明,改进后的算法与基本GWO,WOA,PSO以及SCA相比具有更强的综合寻优性能.选取ACADS边坡考核题进行计算分析,CGWO算法表现出较高的计算精度和收敛速度,能够有效地搜索到复杂分层边坡的最小安全系数.对比有限元强度折减法,该方法具有操作简易、搜索区域易于设置等优点.
PDF
