This compendium describes the multimodal interventions in the field of integrative, complementary, and alternative medicine, which combines biological, behavioral, social, and environmental domains ...rather than merely treating the disease. Research emphasizing the understanding of connections between organs and body systems is the main focus of this text.
This cross-sectional study investigated the correlation between parents' perception and their children's traditional Korean medicine (TKM) use reported by parents in order to discover policy ...intervention points and provide a reference for establishing generalized TKM policies. Participant data from a 2017 national survey on TKM usage was divided into two groups based on the children's TKM use reported by parents. The female participants' children had a higher rate of experience in using TKM (8.1%;
= 0.029). Additionally, 91.4% of the parent group with a child who used TKM turned out to have used TKM, which was higher than 71.9% of the parents whose children never used TKM (
< 0.001). As for the awareness on the use of TKM, 44.0% of the parents with a child who experienced TKM answered they were aware of it, while only 35.3% of the parent group whose child never experienced TKM did so (
= 0.033). The present study suggests that parental experience in using TKM could have an impact on the children's TKM use reported by parents. Further study is necessary to assess which parental factor (awareness level, medical disorder to be treated, therapy, therapeutic efficacy, the purpose of visit, sex, age, etc.) has a close relationship with TKM usage experience of their children.
Background. The current West Africa Ebola virus disease (EVD) outbreak has resulted in multiple individuals being medically evacuated to other countries for clinical management. Methods. We report ...two patients who were transported from West Africa to the United States for treatment of EVD. Both patients received aggressive supportive care measures, as well as an investigational therapeutic (TKM-100802) and convalescent plasma. Results. While one patient experienced critical illness with multi-organ failure requiring mechanical ventilation and renal replacement therapy, both patients recovered without serious long-term sequelae to date. Conclusions. It is unclear what role the experimental drug and convalescent plasma had in the recovery of these patients. Prospective clinical trials are needed to delineate the role of investigational therapies in the care of patients with EVD.
•The electrification potential of the entire Swiss heavy-duty fleet is analyzed.•Electric truck cannot replace Diesel trucks right now, but maybe in the future.•Exemption from permissible weight ...regulations is a prerequisite for electrification.•Battery swapping is crucial to electrify heavy-duty vehicles.•High gravimetric energy density batteries require higher charging power.
Road freight is the most energy-intensive freight mode (per tkm) and runs almost exclusively on fossil fuels. Electrification could change that, but can batteries really power actual heavy-duty operations? This study introduces a data-driven, bottom-up approach to explore the technical limits of electrification using real data from the entire Swiss truck fleet. Full electrification increased the total Swiss electricity demand by about 5% (3 TW h per year) over its current level and avoid about 1 megaton of CO2 per year (accounting for emissions of generation). Realizing this potential required (1) an allowance to exceed current maximum permissible weight regulations, (2) a high-capacity grid access for charging at the home-base (at least 50kW) and (3) a supporting intra-day energy infrastructure (we explored battery swapping). Boosting the gravimetric energy density of the battery cells was generally beneficial, but only effective if the aforementioned conditions were met. Thus, right now, battery electric trucks are no drop-in replacements for their Diesel counterparts. To allow their wide-spread usage, the road-freight sector would have to transform well beyond the vehicle. The required changes are substantial, but not unthinkable. Therefore, we think electric trucks deserve further exploration, in particular regarding their costs, life-cycle impact, technological variants and comparison to competing technologies.
The flora of Kazakhstan is characterized by its wide variety of different types of medicinal plants, many of which can be used on an industrial scale. The Traditional Kazakh Medicine (TKM) was ...developed during centuries based on the six elements of ancient Kazakh theory, associating different fields such as pharmacology, anatomy, pathology, immunology and food nursing as well as disease prevention. The endemic Artemisia L. species are potential sources of unique and new natural products and new chemical structures, displaying diverse bioactivities and leading to the development of safe and effective phytomedicines against prevailing diseases in Kazakhstan and the Central Asia region. This review provides an overview of Artemisia species from Central Asia, particularly traditional uses in folk medicine and the recent numerous phytochemical and pharmacological studies. The review is done by the methods of literature searches in well-known scientific websites (Scifinder and Pubmed) and data collection in university libraries. Furthermore, our aim is to search for promising and potentially active Artemisia species candidates, encouraging us to analyze Protein Tyrosine Phosphatase 1B (PTP1B), α-glucosidase and bacterial neuraminidase (BNA) inhibition as well as the antioxidant potentials of Artemisia plant extracts, in which endemic species have not been explored for their secondary metabolites and biological activities so far. The main result of the study was that, for the first time, the species Artemisia scopiformis Ledeb. Artemisia albicerata Krasch., Artemisia transiliensis Poljakov, Artemisia schrenkiana Ledeb., Artemisia nitrosa Weber and Artemisia albida Willd. ex Ledeb. due to their special metabolites, showed a high potential for α-glucosidase, PTP1B and BNA inhibition, which is associated with diabetes, obesity and bacterial infections. In addition, we revealed that the methanol extracts of Artemisia were a potent source of polyphenolic compounds. The total polyphenolic contents of Artemisia extracts were correlated with antioxidant potential and varied according to plant origin, the solvent of extraction and the analytical method used. Consequently, oxidative stress caused by reactive oxygen species (ROS) may be managed by the dietary intake of current Artemisia species. The antioxidant potentials of the species A. schrenkiana, A. scopaeformis, A. transiliensis and Artemisia scoparia Waldst. & Kitam. were also promising. In conclusion, the examination of details between different Artemisia species in our research has shown that plant materials are good as an antioxidant and eznyme inhibitory functional natural source.
Korean healthcare service is divided into conventional medicine and traditional Korean medicine (TKM). This cross-sectional study compared the older population (65 years and older) with two groups of ...the general population (19–50 years and 51–64 years) to understand the current patterns in the use of TKM services by the older population. Using data from the 2017 National Survey of TKM Usage, we analyzed the main purpose and diseases or symptoms for TKM use, the reason for choosing TKM over other types of medicine, and the treatments provided. Both age groups sought TKM services to “treat a disease”. The top five diseases and symptoms in the older adult (65 and older) group were musculoskeletal and are as follows: arthritis and joint diseases (37.8%, n = 166), disc-related diseases (25.5%, n = 112), back pain (8.4%, n = 37), frozen shoulder and shoulder pain (7.7%, n = 34), and sprain (5.9%, n = 26). The most frequently used treatments for these diseases were acupuncture, moxibustion, cupping, and physiotherapy. The present study suggests that older adults primarily used TKM clinics for the treatment of musculoskeletal diseases. Further studies are necessary to assess the clinical effectiveness of conventional medicine versus TKM versus a combination of both in treating musculoskeletal disorders.
From September 2014 to April 2015, 6 persons who had occupational exposures to Zaire ebolavirus in West Africa received investigational agent rVSV-ZEBOV or TKM-100802 for postexposure prophylaxis and ...were monitored in the United States. All patients experienced self-limited symptoms after postexposure prophylaxis; none developed Ebola virus disease.
The blood stasis pattern in Chinese and Korean traditional Medicine is characterised by stagnation, including extravasated blood and sluggish blood circulation or viscous or congested blood, all of ...which may become pathogenic factors. Blood stasis is associated with chronic and incurable disease, such as pain, infertility, cancer and health reducing conditions caused by stress, which are not relieved with modern medicine. The aim of the study is to establish a modern concept of blood stasis, develop diagnostic tools and diagnostic indices for blood stasis, identify biological indices related to blood stasis.
This community-based, multi-centre trial is designed as an observational study. Data will be collected in order to standardise blood stasis diagnosis in Korea. Patients will be admitted to one of the following 7 hospitals participating in this study: Kyung Hee Oriental Medical Centre, Kyung Hee University Oriental Hospital at Gangdong, Wonkwang Oriental Medical Hospital, Jaseng Hospital of Oriental Medicine, Cha Medical Centre, Pusan National University Korean Medicine Hospital and Dongguk University Ilsan Oriental Hospital. A total of 1400 participants will be recruited through local advertising and doctor referrals from hospitals. At each site, 200–280 participants will be recruited.
All of the research aims, the study design, and the specific methods in this study have been approved by the Institutional Review Boards (IRB) of all seven of the participating hospitals. Additionally, the study was approved by the IRB of the Korean Institute of Oriental Medicine.
CRIS No. KCT 0000916
•Adapted pearl millet hybrids could contribute to food security in West Africa (WA).•Heterosis in population hybrids indicated great potential for hybrid breeding in WA.•Hybrids based on ...inter-country crosses did not differ from intra-country crosses.•Lack of natural heterotic groups requires systematic combining ability studies.
Pearl millet (Pennisetum glaucum (L.) R. Br.) is an important hybrid crop in India. However, to date limited pearl millet hybrid development has been undertaken in West Africa (WA), which is the center of pearl millet origin and diversity and where this crop is most important outside India. Using a diverse set of WA pearl millet germplasm, objectives of this study were to determine the superiority of population hybrids over open-pollinated varieties for agro-morphological and agronomic traits in WA pearl millet germplasm; and (ii) to derive strategies for pearl millet hybrid breeding in WA, based on quantitative-genetic parameters, combining ability and heterotic patterns among geographically close versus distant pearl millet populations. A 10×10 factorial mating design was performed with four parental OPVs from each of five WA countries. The 100 population hybrids and their parents were tested for 14 traits at six locations in one year, thereby using contrasting locations to indirectly sample the rainfall variability inherent to WA pearl millet production environments. Grain yield showed an average panmictic midparent heterosis (PMpH) of 16.7%, ranging from −26 to 73%. The mean grain yield of hybrids based on inter-country crosses did not differ significantly from intra-country crosses. Geographic distance between parents was positively correlated with hybrid grain yield (r=0.31), but not with PMpH . Some crosses between accessions from Niger/Nigeria and Senegal were outstanding. Predictability of population hybrid performance for grain yield was moderate based on midparent values (r=0.43) and slightly better based on general combining ability (GCA) (r=0.56). Overall, pearl millet hybrid breeding in WA seems very promising, but there do not seem to be clear “natural” heterotic groups among WA pearl millet landraces. Such heterotic groups as the basis of sustainable hybrid breeding need rather to be created systematically, by building on existing combining ability patterns and aiming to maximize combining ability between the groups.
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