By the end of World War II, hundreds of thousands of young men in the Japanese colonies, in particular Taiwan and Korea, had expressed their loyalty to the empire by volunteering to join the army. ...Why and how did so many colonial youth become passionate supporters of Japanese imperial nationalism? And what happened to these youth after the war?Nation-Empireinvestigates these questions by examining the long-term mobilization of youth in the rural peripheries of Japan, Taiwan, and Korea. Personal stories and village histories vividly show youth's ambitions, emotions, and identities generated in the shifting conditions in each locality. At the same time, Sayaka Chatani unveils an intense ideological mobilization built from diverse contexts-the global rise of youth and agrarian ideals, Japan's strong drive for assimilation and nationalization, and the complex emotions of younger generations in various remote villages.
Nation-Empireengages with multiple historical debates. Chatani considers metropole-colony linkages, revealing the core characteristics of the Japanese Empire; discusses youth mobilization, analyzing the Japaneseseinendan(village youth associations) as equivalent to the Boy Scouts or the Hitler Youth; and examines society and individual subjectivities under totalitarian rule. Her book highlights the shifting state-society transactions of the twentieth-century world through the lens of the Japanese Empire, inviting readers to contend with a new approach to, and a bold vision of, empire study.
Thiazolidin-4-ones is an important heterocyclic ring system of a pharmacophore and a privileged scaffold in medicinal chemistry. This review is focused on the latest scientific reports regarding ...biological activities of thiazolidin-4-ones published in 2020 and 2021. The review covers recent information about antioxidant, anticancer, anti-inflammatory, analgesic, anticonvulsant, antidiabetic, antiparasitic, antimicrobial, antitubercular and antiviral properties of thiazolidin-4-ones. Additionally, the influence of different substituents in molecules on their biological activity was discussed in this paper. Thus, this study may help to optimize the structure of thiazolidin-4-one derivatives as more efficient drug agents. Presented information may be used as a practical hint for rational design of new small molecules with biological activity, especially among thiazolidin-4-ones.
Understanding structure-activity relationships (SARs) for a given set of molecules allows one to rationally explore chemical space and develop a chemical series optimizing multiple physicochemical ...and biological properties simultaneously, for instance, improving potency, reducing toxicity, and ensuring sufficient bioavailability. In silico methods allow rapid and efficient characterization of SARs and facilitate building a variety of models to capture and encode one or more SARs, which can then be used to predict activities for new molecules. By coupling these methods with in silico modifications of structures, one can easily prioritize large screening decks or even generate new compounds de novo and ascertain whether they belong to the SAR being studied. Computational methods can provide a guide for the experienced user by integrating and summarizing large amounts of preexisting data to suggest useful structural modifications. This chapter highlights the different types of SAR modeling methods and how they support the task of exploring chemical space to elucidate and optimize SARs in a drug discovery setting. In addition to considering modeling algorithms, I briefly discuss how to use databases as a source of SAR data to inform and enhance the exploration of SAR trends. I also review common modeling techniques that are used to encode SARs, recent work in the area of structure-activity landscapes, the role of SAR databases, and alternative approaches to exploring SAR data that do not involve explicit model development.
As technology becomes an ever-more prevalent part of everyday life, and population-based physical activity programs seek new ways to increase life-long engagement with physical activity, these two ...ideas have become increasingly linked. This Special Issue attempts to offer a thorough and critical examination of emerging technologies in physical activity and health promotion, considering technological interventions in different contexts (communities, clinics, schools, homes, etc.) among various populations, exploring the challenges of integrating technology into physical activity promotion, and offering solutions for its implementation. This Special Issue aims to take a broadly positive stance toward interactive technology initiatives and, while discussing some negative implications of an increased use of technology, offers practical recommendations for promoting physical activity through various emerging technologies, including, but not limited to: Active video games (exergaming); social media; mobile device apps; health wearables; mobile games, augmented reality games, global positioning and geographic information systems; and virtual reality. Offering a logical and clear critique of emerging technologies in physical activity and health promotion, this Special Issue will provide useful suggestions and practical implications for researchers, practitioners, and educators in the fields of public health, kinesiology, physical activity and health, and healthcare.
Flavonols are one of the most promising class of bioactive compounds belonging to the broad family of the flavonoids, characterized by a unique set of features in their basic chemical skeleton and ...several specific substitutions in selected position of the rings A, B and C. This interesting class of phytochemicals includes compounds such as quercetin, kaempferol, myricetin, rhamnetin, morin, fisetin, galagin, azaleatin and their respective glycosyl derivatives. They have been identified in several foods and provide them great health benefits.
This review updates and integrates, in a critical fashion, the current knowledge on flavonols as food sources, chemical features, structure-activity relationships, bioavailability and health benefits (from preclinical and clinical studies), focusing on both in vitro and in vivo reports.
Dietary flavonols are bioavailable molecules in human with impressive health benefits (such as antioxidation, cardioprotection, antibacterial, antiviral and anticancer activity) and the process of metabolization also produces compounds with remarkable bioactivities just like the corresponding precursors. Their inclusion into human diet is highly recommended for their unquestionable health promoting properties, being excellent nutraceuticals as well as ingredients for good functional food.
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•Food flavonols are nutraceuticals with remarkable biological applications.•Basic skeleton of flavonols has characteristic features for their functionality.•Some foods in the human diet are very rich source of flavonols.•Flavonols have promising anticancer, antimicrobial, antioxidant and antiviral properties.
Heat shock protein 90 (Hsp90) is an ATP-dependent molecular chaperone which is essential in eukaryotes. It is required for the activation and stabilization of a wide variety of client proteins and ...many of them are involved in important cellular pathways. Since Hsp90 affects numerous physiological processes such as signal transduction, intracellular transport, and protein degradation, it became an interesting target for cancer therapy. Structurally, Hsp90 is a flexible dimeric protein composed of three different domains which adopt structurally distinct conformations. ATP binding triggers directionality in these conformational changes and leads to a more compact state. To achieve its function, Hsp90 works together with a large group of cofactors, termed co-chaperones. Co-chaperones form defined binary or ternary complexes with Hsp90, which facilitate the maturation of client proteins. In addition, posttranslational modifications of Hsp90, such as phosphorylation and acetylation, provide another level of regulation. They influence the conformational cycle, co-chaperone interaction, and inter-domain communications. In this review, we discuss the recent progress made in understanding the Hsp90 machinery.
Although stereotypically homogenized and hostile to immigrants, Japan has experienced an influx of foreigners from Asia and Latin America in recent decades. InFighting for Foreigners, Apichai W. ...Shipper details how, in response, Japanese citizens have established a variety of local advocacy groups-some faith based, some secular-to help immigrants secure access to social services, economic equity, and political rights.
Drawing on his years of ethnographic fieldwork and a pragmatic account of political motivation he calls associative activism, Shipper asserts that institutions that support illegal foreigners make the most dramatic contributions to democratic multiculturalism. The changing demographics of Japan have been stimulating public discussions, the political participation of marginalized groups, and calls for fair treatment of immigrants. Nongovernmental organizations established by the Japanese have been more effective than the ethnically particular associations formed by migrants themselves, Shipper finds. Activists who initially work in concert to solve specific and local problems eventually become more ambitious in terms of political representation and opinion formation.
As debates about the costs and benefits of immigration rage across the developed world, Shipper's research offers a refreshing new perspective: rather than undermining democracy in industrialized society, immigrants can make a positive institutional contribution to vibrant forms of democratic multiculturalism.
For two thousand years the disparate groups that now reside in Zomia (a mountainous region the size of Europe that consists of portions of seven Asian countries) have fled the projects of the ...organized state societies that surround them-slavery, conscription, taxes, corvée labor, epidemics, and warfare. This book, essentially an "anarchist history," is the first-ever examination of the huge literature on state-making whose author evaluates why people would deliberately and reactively remain stateless. Among the strategies employed by the people of Zomia to remain stateless are physical dispersion in rugged terrain; agricultural practices that enhance mobility; pliable ethnic identities; devotion to prophetic, millenarian leaders; and maintenance of a largely oral culture that allows them to reinvent their histories and genealogies as they move between and around states.
In accessible language, James Scott, recognized worldwide as an eminent authority in Southeast Asian, peasant, and agrarian studies, tells the story of the peoples of Zomia and their unlikely odyssey in search of self-determination. He redefines our views on Asian politics, history, demographics, and even our fundamental ideas about what constitutes civilization, and challenges us with a radically different approach to history that presents events from the perspective of stateless peoples and redefines state-making as a form of "internal colonialism." This new perspective requires a radical reevaluation of the civilizational narratives of the lowland states. Scott's work on Zomia represents a new way to think of area studies that will be applicable to other runaway, fugitive, and marooned communities, be they Gypsies, Cossacks, tribes fleeing slave raiders, Marsh Arabs, or San-Bushmen.
Serum Albumin: A Multifaced Enzyme De Simone, Giovanna; di Masi, Alessandra; Ascenzi, Paolo
International journal of molecular sciences,
09/2021, Volume:
22, Issue:
18
Journal Article
Peer reviewed
Open access
Human serum albumin (HSA) is the most abundant protein in plasma, contributing actively to oncotic pressure maintenance and fluid distribution between body compartments. HSA acts as the main carrier ...of fatty acids, recognizes metal ions, affects pharmacokinetics of many drugs, provides the metabolic modification of some ligands, renders potential toxins harmless, accounts for most of the anti-oxidant capacity of human plasma, and displays esterase, enolase, glucuronidase, and peroxidase (pseudo)-enzymatic activities. HSA-based catalysis is physiologically relevant, affecting the metabolism of endogenous and exogenous compounds including proteins, lipids, cholesterol, reactive oxygen species (ROS), and drugs. Catalytic properties of HSA are modulated by allosteric effectors, competitive inhibitors, chemical modifications, pathological conditions, and aging. HSA displays anti-oxidant properties and is critical for plasma detoxification from toxic agents and for pro-drugs activation. The enzymatic properties of HSA can be also exploited by chemical industries as a scaffold to produce libraries of catalysts with improved proficiency and stereoselectivity for water decontamination from poisonous agents and environmental contaminants, in the so called “green chemistry” field. Here, an overview of the intrinsic and metal dependent (pseudo-)enzymatic properties of HSA is reported to highlight the roles played by this multifaced protein.
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