Diabetic wounds can occur as a prevalent complication among people diagnosed with diabetes, frequently resulting in the necessity for amputation. The cause and effect of diabetic foot ulcer is ...complex, involving multiple factors. In the present study, wound healing strategies utilizing nanomaterials have proven to be effective in battling bacterial infections and improve wound regeneration. Poloxamers (PLX) exhibit extensive potential as a viable option for the development of nanomedicines owing to their inherent characteristics of self-assembly and encapsulation. This study aims to design and develop a PLX/ZnO nanocomposite incorporated with Centella Asiatica extract (CAE) for the multi-functional action in the diabetic wound healing treatment. Subsequently physico-chemical characterizations, such as XRD, FTIR, and TEM observations, demonstrated that the ZnO were evenly distributed through the PLX framework. The developed nanocomposite was biocompatible with mouse fibroblast cell line (L929), and it had multiple beneficial characteristics, such as a rapid self-healing process and effective antibacterial action against G+ and G− bacterial pathogens. After being treated with the developed formulation, skin fibroblast cell line and HUVECs demonstrated a substantial increase in their in vitro cell proliferation ability, migration, and tube-forming abilities. The utilization of a CAE@PLX/ZnO nanoformulation presents a viable strategy and a distinctive, encouraging composite for diabetic wound healing treatment.
Purpose of Review
Zeolite is an aluminosilicate compound having a wide spectrum of applications in medicine and dentistry. Several articles were published combining zeolites with various other ...elements for different applications in dentistry. This review aims to provide a detailed review on the origin of zeolites, their physical and chemical properties and possible applications as dental materials.
Recent Findings
Zeolite-based hybrid films can be used for detection of oral cancers. Silver zeolite can be added in restorative materials and dental liners. In cases of root canal irrigation, chlorhexidine zeolite is used owing to its antibacterial properties. For dental implants, a zeolite coating can improve the osseointegration.
Summary
Due to its microporous structure, application-driven zeolitic frameworks can be prepared by sieving in various cations and antibacterial compounds. This review helps improve our understanding regarding the uses of zeolites as a material in different aspects of dentistry along with possible further improvements as a dental material.
Most strains of Gram-positive and Gram-negative bacteria were inhibited by 50–100 mg/l of the anti-inflammatory agent, diclofenac sodium (Dc). In vivo test using 30 or 50 μg Dc per 20 g mouse (Swiss ...Albino variety) significantly (
P <0.001) protected the animals when challenged with 50 MLD of a virulent
Salmonella typhimurium. The anti-bacterial action of Dc was found to be due to inhibition of DNA synthesis which was demonstrated using 2 μ Ci (
3H) deoxythymidine uptake.
