Natural antioxidants are more attractive than synthetic chemical oxidants because of their non-toxic and non-harmful properties. Microalgal bioactive components such as carotenoids, polysaccharides, ...and phenolic compounds are gaining popularity as very effective and long-lasting natural antioxidants. Few articles currently exist that analyze microalgae from a bibliometric and visualization point of view. This study used a bibliometric method based on the Web of Science Core Collection database to analyze antioxidant research on bioactive compounds in microalgae from 1996 to 2022. According to cluster analysis, the most studied areas are the effectiveness, the antioxidant mechanism, and use of bioactive substances in microalgae, such as carotene, astaxanthin, and tocopherols, in the fields of food, cosmetics, and medicine. Using keyword co-occurrence and keyword mutation analysis, future trends are predicted to improve extraction rates and stability by altering the environment of microalgae cultures or mixing extracts with chemicals such as nanoparticles for commercial and industrial applications. These findings can help researchers identify trends and resources to build impactful investigations and expand scientific frontiers.
Bone tissue constitutes 15–20% of human body weight and plays a crucial role in supporting the body, coordinating movement, regulating mineral homeostasis, and hematopoiesis. The maintenance of bone ...homeostasis relies on a delicate balance between osteoblasts and osteoclasts. Osteoclasts, as the exclusive “bone resorbers” in the human skeletal system, are of paramount significance yet often receive inadequate attention. When osteoclast activity becomes excessive, it frequently leads to various bone metabolic disorders, subsequently resulting in secondary bone injuries, such as fractures. This not only reduces life quality of patients, but also imposes a significant economic burden on society. In response to the pressing need for biomaterials in the treatment of osteoclast dysregulation, there is a surge of research and investigations aimed at osteoclast regulation. Promising progress is achieved in this domain. This review seeks to provide a comprehensive understanding of how to modulate osteoclast activities. It summarizes bioactive substances that influence osteoclasts and elucidates strategies for constructing related biomaterial systems. It offers practical insights and ideas for the development and application of biomaterials and tissue engineering, with the hope of guiding the clinical treatment of osteoclast‐related bone diseases using biomaterials in the future.
Osteoclasts, as the exclusive “bone resorbers” in the human skeletal system, are of paramount significance yet often receive inadequate attention. This review seeks to provide a comprehensive understanding of osteoclast modulation, which summarizes bioactives that influence osteoclasts, and elucidates strategies for constructing related biomaterial systems, offering practical insights and ideas for the development and application of biomaterials and tissue engineering.
Dry white wines with an increased content of bioactive substances, known as "Orange wines," have become a captivating subject in the wine industry, rooted in the millennia-old tradition of the South ...Caucasus and gaining global popularity. In the Republic of Moldova, producers such as ”Crama Domească”, ”Gogu Winery”, and ”Vinăria Novac” have explored the "Orange wine" method with indigenous cultivars, bringing innovations to the wine landscape. The study, conducted at the Laboratory of "Biotechnologies and Microbiology of Wine," focused on four promising local cultivars: 'Viorica', 'Floricica', 'Riton', and 'Legenda'. To optimize the content of bioactive substances, the process involved selecting grapes at technological maturity, crushing-destemming with sulfiting, and fermentation with active yeasts. The maceration-fermentation process, ranging from 30 to 90 days, proved to be a crucial factor for the maximum extraction of phenolic substances. Physico-chemical analyses revealed slight changes in titratable acidity and pH, remaining within appropriate limits, with significant concentrations of antioxidant phenolic substances. In this context, "Orange" wines from Moldavian cultivars have demonstrated the potential to provide an innovative alternative in the wine market. However, in light of the results, further studies are recommended to precisely determine the influence of technological procedures on the composition of "Orange" wines and identify other cultivars with increased potential. This approach would strengthen the position of the Republic of Moldova in the production of wines with high bioactive substance content, solidifying its reputation in the global wine landscape.
Human skin is continually changing. The condition of the skin largely depends on the individual's overall state of health. A balanced diet plays an important role in the proper functioning of the ...human body, including the skin. The present study draws attention to bioactive substances, i.e., vitamins, minerals, fatty acids, polyphenols, and carotenoids, with a particular focus on their effects on the condition of the skin. The aim of the study was to review the literature on the effects of bioactive substances on skin parameters such as elasticity, firmness, wrinkles, senile dryness, hydration and color, and to define their role in the process of skin ageing.
The main objective of this study is to optimize and analyze the bioactive substances of functional tea prepared from
Ficus carica
L. leaves according to the traditional practices in Kabylia regions ...(Tipaza and Tizi-Ouzou). The optimal extraction conditions of total phenolic content (TPC), total flavonoid content (TFC), tannin content (TC), and total chlorophyll content (TCC) were determined using the response surface methodology (RSM). The main results show that the optimum extraction conditions were 18.36 min at 41.15 °C with a particle size of 52.27 µm. Other therapeutic effects have to be revealed and demonstrated. The prepared tea characterized by a high TPC value of about 203.713 g GAE/100 g d.b.
L’objectif principal de cette étude est d’optimiser et d’analyser les substances bioactives d’un thé fonctionnel préparé à partir de feuilles de
Ficus carica
L. selon les pratiques traditionnelles de la population des régions de Kabylie (Tipaza et Tizi-Ouzou). L’optimisation des conditions d’extraction des polyphénoliques totaux (PPT), des flavonoïdes totaux (FT), de la teneur des tannins (TT) et de la teneur totale de la chlorophylle (TTC) a été réalisée en appliquant la méthodologie de surface de réponse (MSR). Les principaux resultats montrent que les conditions d’extraction optimales etaient : 18,36 minutes a 41,15 °C et une taille de grain de 52,27 µm. D’autres effets therapeutiques doivent etre reveles et demontres. Le the elabore se caracterise par une concentration tres elevee en PPT de l’ordre de 203,713 g EAG/100 g MS.
Some bioactive substances in food have problems such as poor solubility, unstable chemical properties and low bioavailability, which limits their application in functional food. Recently, many egg ...white protein-based delivery carriers have been developed to improve the chemical stability, biological activity and bioavailability of bioactive substances. This article reviewed the structure and properties of several major egg white proteins commonly used to construct bioactive substance delivery systems. Several common carrier types based on egg white proteins, including hydrogels, emulsions, micro/nanoparticles, aerogels and electrospinning were then introduced. The biological functions of common bioactive substances, the limitations, and the role of egg white protein-based delivery systems were also discussed. At present, whole egg white protein, ovalbumin and lysozyme are most widely used in delivery systems, while ovotransferrin, ovomucoid and ovomucin are less developed and applied. Egg white protein-based nanoparticles are currently the most commonly used delivery carriers. Egg white protein-based hydrogels, emulsions, and microparticles are also widely used. Future research on the application of various egg white proteins in developed new delivery systems will provide more choices for the delivery of various bioactive substances.
Blood transfusion in critically ill individuals such as sepsis was associated with higher morbidity and mortality. During storage, various bioactive substances accumulated, may exacerbate the initial ...immunosuppressive reaction in severely ill patients. The objective of this study is to explore how resin adsorption impacts the accumulation of cytokines and the presence of extracellular microvesicles (EVs) in whole blood. Through comparative analysis and screening, amberchrom CG 300 C was chosen to assess the adsorption efficiency and evaluate the quality of whole blood after adsorption. Subsequently, the supernatants from both the unadsorpted (UA) and adsorpted (A) groups were co-cultured with peripheral blood mononuclear cells (PBMCs) to assess their effects on cellular growth and cytokine concentrations. The findings of our study revealed that resin adsorption effectively eradicated most bioactive components in conserved blood, including IL-8, TGF-β, sCD40L, sFasL, without affecting the quality of the blood. Furthermore, scanning electron microscopy (SEM) revealed a reduction in extracellular microvesicles following adsorption. Compared to UA, A 's supernatant markedly enhanced PBMC growth (p < 0.01). Additionally, the A's supernatant markedly diminished the emission of pro-inflammatory cytokines, like IL-6. The research revealed that adsorbing resin effectively reduced bioactive substances from preserved whole blood, and did not impact red blood cell quality, proving to be a reliable method for extracting bioactive substances from storage blood. The results could pave the way for creating innovative blood bags and hold clinical significance in lowering the frequency of TRIM among patients who have undergone transfusions.
New research has begun to develop safe and effective alternatives to feed-antibiotics as growth enhancers in response to mounting pressure on the poultry sector to do so. There is a significant ...demand for poultry products all across the world right now. To achieve this goal, key performance indicators are optimized, such as the rate of chicken growth, the amount of feed used, and the health of the flock as a whole. As a result of this growing need, various alternatives to antibiotics have entered the market. New approaches are desperately needed to keep poultry productivity and efficiency at a high level in the face of mounting pressure to limit the use of antibiotics. Recent years have seen an uptick in interest in the potential of aromatic plant extracts as growth and health boosters in poultry. The great majority of plants' positive effects are accounted for by essential oils (EOs) and other secondary metabolites. EOs have been proven to promote digestive secretion production, improve blood circulation, exert antioxidant qualities, reduce levels of dangerous microbes, and maybe improve the immune status of poultry. EOs are often believed to be safe, non-toxic alternatives because they are all-natural, chemical-free, and devoid of potentially harmful deposits. EOs are extracted from plants, and while there are thousands of them, only approximately 300 have been deemed to have significant commercial value. Many different types of bacteria, viruses, fungi, and parasites are negatively affected by EOs in multiple studies conducted both in vitro and in vivo. The review covers the fundamentals of EOs, their anti-oxidant and immunomodulatory capabilities, their growth-promoting benefits, and their effectiveness against numerous diseases in poultry.
OVA (ovalbumin)/CMC (sodium carboxymethylcellulose) nanoparticles are prepared by combining complex coacervation and thermal induction. The effect of different parameters on stability of OVA/CMC ...nanoparticles (different ratios, pH, temperature, salt concentration and storage time) is investigated. And then the loading and stabilizing mechanism of particles on curcumin are further analyzed. After heating, OVA and CMC in particle could further cross-linking and a highly salt-tolerant and ultra-long stable nanoparticle can be formed. OVA/CMC nanoparticle with the loose structure of wool ball could effectively load curcumin with the loading content and loading efficiency of 36.40 and 95.40%, 36.30 and 92.82%, 36.0 and 94.48% for the ratios of 1:2, 1:1 and 2:1, respectively. Curcumin-loaded of OVA/CMC nanoparticles show good DPPH· scavenging activity, Ferric-reducing ability and ABTS+ scavenging activity compared with curcumin/water. The results can be useful for designing food and beverage particle with improving bioactive substances functional properties.
•OVA/CMC nanoparticles were prepared by combining complex coacervation and thermal induction.•Nanoparticles showed ultra-long stability and high salt concentration tolerance.•OVA/CMC nanoparticles with concave/convex structure exhibited good curcumin load capacity.•Curcumin-loaded nanoparticles showed and improved antioxidant activity than free curcumin in water.
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