Zusammenfassung Die Zukunft scheint unsicher, ja bedrohlich. Ob Klimawandel, möglicher Kollaps der Märkte oder die Entwicklung der westlichen Demokratien: Allgegenwärtig sieht man sich mit möglichen ...Katastrophen konfrontiert. Mit den intensiv darüber geführten Zukunftsdiskursen beschäftigen sich die Autorinnen und Autoren dieses interdisziplinären Bands, und zwar in analytisch-historischen Perspektiven. Denn die Art und Weise, wie man die Zukunft in den Blick nimmt, ist weder beliebig noch allgemein, sondern stark von religiös-apokalyptischen Denkmustern und Vorstellungswelten geprägt. Die ausführlichen Hintergrundanalysen geben überraschende Antworten auf apokalyptische Szenarien unserer Zeit. Abstract Negative expectations saturate the current debates about the future, and apocalyptic images are omnipresent. Are there other reasons for this than mere facts? The interdisciplinary studies by the fellows of the ZRWP’s Basler Forschungskolleg (Basel Research School) that are collated here address this question—and find surprising answers.
Monkey Grip is viewed as a film that evokes the sexual politics of feminism and of city life, and can thus be seen as both a feminist film and a 'Melbourne film', a convergence that emerges in other ...films made and set in Melbourne, including Love and Other Catastrophes. The city appears as a centre of dwelling and habitation, with attention drawn to the spectacle of the interiors of the residences, in which much of the action occurs, and with reflection on the conditions and values of production. Bachelard's notion of the house image is applied to distinguish the performances of gender from those in films in non-urban settings.
A series of radioactive catastrophes (from 1948 to 1967) in the Southern Urals in the USSR led to intensive environmental contamination. Radioactive wastes were dispersed over the 20
000 km
2 ...territory of four provinces—Chelyabinsk, Sverdlovsk, Tyumen’ and Kurgan—due to the activity of the military facility that was built in 1948 for the production of nuclear bomb plutonium. The results of 50 years of investigations into the consequences of these disasters allow a general picture of the events that occurred to be reconstructed and allow the medical consequences of the irradiation of about half a million residents to be depicted. However, due to the atmosphere of secrecy and inadequate medical procedures, the results of medical studies of radiation victims are scant. The current protocols present a unique opportunity to study the DNA damage at the nucleotide resolution level in the genome of inhabitants of the given region, who presumably received chronic doses of irradiation. Studies were conducted through the direct sequencing of genes after their PCR-amplification and preselection of allegedly mutated DNA molecules. The regions of two genes have been sequenced: D1 dopamine receptor gene (subfamily of the G-protein coupled receptor L-DOPA genes) and the intron 12 of the gene for phenylalanine hydroxylase (PAH) responsible for phenylketonuria or hyperphenylalaninemia. Six point mutations (four presumably new) were found in the D1 gene of 42 persons and five polymorphic loci (two of which are widespread and three are unique) were revealed in the PAH gene. One of two widespread mutations is a deletion, and the other four are substitutions. Mutations in the controls were not found.
This paper focuses on agricultural production risk management, explaining key concepts, understanding why crop insurance markets have been slow to develop, and making recommendations about how to ...build sustainable markets in developing country contexts, with information drawn from Latin America and the Caribbean. The paper identifies three types of natural phenomena as the dominant risks to agicultural yield. They are: hydro-meteorological (rain, floods, droughts, high winds, tornados, hurricanes)geological (including earthquakes, volcanic eruptions, and tsunamis)biological (including include diseases and insect infestations).It further classifies these risks as either catastrophic or non-catastrophic, depending on frequency, scale, intensity, and duration and notes that over the last decade the occurrence of natural disasters has been trending upward.The paper notes that farmers in most developing countries have little access to formal agricultural insurance products that would allow them to transfer production risk to other parties. However, it also notes that agricultural insurance is reemerging as a topic of interest, especially in light of the need to improve agricultural competitiveness in increasingly integrated commodity markets.The paper presents challenges in providing this service, including lack of information, inability to pay high premiums and the the tendency of governments to undermine market development through inappropriate use of subsidies and disaster relief funds. It recommends that:farm insurance should not be not be seen as a panacea for unprofitable farms, management failuresgovernments have a vital role to play in providing the necessary information needed to measure, evaluate, and monitor risk, but also need to put public funds into creating favourable market conditions for the development of the industryfarmers should be trained how to reduce and cope effectively with some of the production risks on-farm through better management practices and diversification strategiesrules for accessing governmental disaster relief should not remove or undercut incentives for the adoption of better on-farm management techniques, the purchase of private agricultural insurance, or the accumulation of personal savings.
We consider the product of spectral projectionsΠε(λ)=1(−∞,λ−ε)(H0)1(λ+ε,∞)(H)1(−∞,λ−ε)(H0) where H0 and H are the free and the perturbed Schrödinger operators with a short range potential, λ>0 is ...fixed and ε→0. We compute the leading term of the asymptotics of Trf(Πε(λ)) as ε→0 for continuous functions f vanishing sufficiently fast near zero. Our construction elucidates calculations that appeared earlier in the theory of “Anderson's orthogonality catastrophe” and emphasizes the role of Hankel operators in this phenomenon.
The article covers the main medical and demographic problems of Ukraine: birth-rate decline, growth of mortality; moving of qualified personnel abroad, which led to a decrease in the population over ...the years of independence by more than 9.5 million people. The total birth rate in Ukraine in 2017 was 10.3 per 1000 people, which is 14.9% lower than in 1991. The lowest birth rate was observed in 2000-2002 (7.8, 7.7, 8.1). Then gradually there is an increase in the indicators in 2012 - 11.4 per 1000 people. The total mortality rate in 2017 is 14.4, which is 11.6% higher than in 1991. According to the analysis period, the lowest mortality rate was registered in 1991 - 12.9%. The most high-speed in the period 2005-2008. (16.6, 16.2, 16.4). The natural increase from -0.8 dropped to-4.1 (more than 5 times). The demographic situation in Ukraine is characterized by depopulation, it is characterized by demographic crisis, the main features of which are adverse changes not only in the number but also in the healthy of population, which is manifested in the decrease in the average life expectancy, the deterioration of the health of children and adolescents, the growth of malformations among newborns, high mortality rates from circulatory system diseases; oncological diseases, injuries, poisonings and other consequences of external causes; men's super mortality. The main causes of these phenomena are the protracted economic crisis, the ecological catastrophe (Chernobyl), the country's being in a state of hybrid war, which led to a sharp decline in living standards, uncertainty of the population in the future deaths of people. We offered some ways to over come the country's demographic crisis.
Osteosarcoma is the most common primary malignant tumor of bone, which frequently occurs in the second decade of life. Despite the improvements in neoadjuvant chemotherapy, the outcome of patients ...with chemoresistant or metastatic tumors is still poor. Therefore, there is a need for the development of more efficient therapeutic agents. BI 2536, an innovative selective inhibitor of Polo-like kinase 1, has shown anticancer potential promoting mitotic arrest and apoptosis in a variety of tumor cells, including osteosarcoma. Here, we present more evidence of the antiproliferative effects of BI 2536 on HOS and MG-63 osteosarcoma cell lines. Our results showed that nanomolar concentrations (10, 50, and 100 nmol/l) of the drug significantly decreased cell proliferation and clonogenic capacity, inducing mitotic arrest and aneuploidy. Interestingly, although BI 2536 mediated a moderate increase of apoptosis after 48 h in HOS cells, no increased caspase-3 activity was detected for MG-63 cells. In contrast to previous studies, we show that perturbation of normal mitotic progression by BI 2536 in these osteosarcoma cell lines results in caspase-independent mitotic catastrophe followed by necrosis. Our findings reinforce the likelihood of directing against Polo-like kinase 1 as a therapeutic option in the treatment of osteosarcoma.
Zwei 'jahrhunderthochwasser' in elf jahren - ein vergleich der hochwasserereignisse von 2002 und 2013 (in Deutschland). Worldwide floods are among the most frequent and most momentous natural ...disasters. They occur in unpredictable intervals and dimensions and always bring particularly devastating or catastrophic impacts, if they get into contact with people or its uses. Within eleven years only Germany was affected of two so-called 'century-floods'. The expiry of extreme high water can be influenced by technical measures only up to a certain degree. It is therefore necessary to have a high protection from the effects of floods and to keep the impact as low as possible. Both being prepared as well as possible and being capable of acting for the case of emergency are corequisite. Flood protection is a longsome and s steadily continuing process. In dealing with the consequences of floods both political measures and the commitment and solidarity of the citizens were in demand.
In this paper, we prove the presence of limit cycles of given multiplicity, together with a complete unfolding, in families of (singularly perturbed) polynomial Liénard equations. The obtained limit ...cycles are relaxation oscillations. Both classical Liénard equations and generalized Liénard equations are treated.
PDF
