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  • Minimum Information for Reporting on the Comet Assay (MIRCA): recommendations for describing comet assay procedures and results
    Møller, Peter; Azqueta, Amaya; Boutet-Robinet, Elisa ... Nature protocols, 12/2020, Volume: 15, Issue: 12
    Journal Article
    Peer reviewed
    Open access

    The comet assay is a widely used test for the detection of DNA damage and repair activity. However, there are interlaboratory differences in reported levels of baseline and induced damage in the same ...
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  • Measuring DNA modifications with the comet assay: a compendium of protocols
    Collins, Andrew; Møller, Peter; Gajski, Goran ... Nature protocols, 03/2023, Volume: 18, Issue: 3
    Journal Article
    Peer reviewed
    Open access

    The comet assay is a versatile method to detect nuclear DNA damage in individual eukaryotic cells, from yeast to human. The types of damage detected encompass DNA strand breaks and alkali-labile ...
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  • Technical recommendations t... Technical recommendations to perform the alkaline standard and enzyme-modified comet assay in human biomonitoring studies
    Azqueta, Amaya; Muruzabal, Damian; Boutet-Robinet, Elisa ... Mutation research, 07/2019, Volume: 843
    Journal Article
    Peer reviewed
    Open access

    •The comet assay is widely used in human biomonitoring to measure DNA damage.•Variation in comet assay results between laboratories has been a problem.•Specific steps in the assay have been ...
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  • The comet assay applied to ... The comet assay applied to HepG2 liver spheroids
    Elje, Elisabeth; Hesler, Michelle; Rundén-Pran, Elise ... Mutation research, September 2019, 2019-09-00, Volume: 845
    Journal Article
    Peer reviewed
    Open access

    •HepG2 liver spheroids preparation was standardized in independent laboratories.•Comet assay was applied successfully to HepG2 liver spheroids for the first time.•A difference in sensitivity was ...
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  • Measuring oxidative damage ... Measuring oxidative damage to DNA and its repair with the comet assay
    Collins, Andrew R. Biochimica et biophysica acta, 02/2014, Volume: 1840, Issue: 2
    Journal Article
    Peer reviewed

    Single cell gel electrophoresis, or the comet assay, was devised as a sensitive method for detecting DNA strand breaks, at the level of individual cells. A simple modification, incorporating a ...
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  • DNA damage and repair measu... DNA damage and repair measured by comet assay in cancer patients
    Vodicka, Pavel; Vodenkova, Sona; Opattova, Alena ... Mutation research, July 2019, 2019-07-00, Volume: 843
    Journal Article
    Peer reviewed

    •Comet assay is effective and sensitive in the monitoring of DNA damage in cancer patients.•Comet assay-based DNA damage and DNA repair measurement may be used to follow the dynamic of malignant ...
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  • Single cell trapping and DN... Single cell trapping and DNA damage analysis using microwell arrays
    Wood, David K; Weingeist, David M; Bhatia, Sangeeta N ... Proceedings of the National Academy of Sciences - PNAS, 06/2010, Volume: 107, Issue: 22
    Journal Article
    Peer reviewed
    Open access

    With a direct link to cancer, aging, and heritable diseases as well as a critical role in cancer treatment, the importance of DNA damage is well-established. The intense interest in DNA damage in ...
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  • The Comet assay for the eva... The Comet assay for the evaluation of genotoxic impact in aquatic environments
    Frenzilli, G.; Nigro, M.; Lyons, B.P. Mutation research, 01/2009, Volume: 681, Issue: 1
    Journal Article
    Peer reviewed

    This review considers the potential of the Comet assay (or Single Cell Gel Electrophoresis, SCGE) to evaluate the environmental impact of genotoxins in aquatic environments. It focuses on in vivo and ...
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  • An overview of apoptosis as... An overview of apoptosis assays detecting DNA fragmentation
    Majtnerová, Pavlína; Roušar, Tomáš Molecular biology reports, 10/2018, Volume: 45, Issue: 5
    Journal Article
    Peer reviewed
    Open access

    Apoptosis has been recognized as a type of programmed cell death connected with characteristic morphological and biochemical changes in cells. This programmed cell death plays an important role in ...
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  • The comet assay in animal m... The comet assay in animal models: From bugs to whales – (Part 1 Invertebrates)
    Gajski, Goran; Žegura, Bojana; Ladeira, Carina ... Mutation research, January-March 2019, 2019 Jan - Mar, 2019-01-00, 2019, Volume: 779
    Journal Article
    Peer reviewed
    Open access

    The comet assay, also called single cell gel electrophoresis, is a sensitive, rapid and low-cost technique for quantifying and analysing DNA damage and repair at the level of individual cells. The ...
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