The influence of nanoscale surface topography on protein adsorption is highly important for numerous applications in medicine and technology. Herein, ferritin adsorption at flat and nanofaceted, ...single-crystalline Alsub.2Osub.3 surfaces is investigated using atomic force microscopy and X-ray photoelectron spectroscopy. The nanofaceted surfaces are generated by the thermal annealing of Alsub.2Osub.3 wafers at temperatures above 1000 °C, which leads to the formation of faceted saw-tooth-like surface topographies with periodicities of about 160 nm and amplitudes of about 15 nm. Ferritin adsorption at these nanofaceted surfaces is notably suppressed compared to the flat surface at a concentration of 10 mg/mL, which is attributed to lower adsorption affinities of the newly formed facets. Consequently, adsorption is restricted mostly to the pattern grooves, where the proteins can maximize their contact area with the surface. However, this effect depends on the protein concentration, with an inverse trend being observed at 30 mg/mL. Furthermore, different ferritin adsorption behavior is observed at topographically similar nanofacet patterns fabricated at different annealing temperatures and attributed to different step and kink densities. These results demonstrate that while protein adsorption at solid surfaces can be notably affected by nanofacet patterns, fine-tuning protein adsorption in this way requires the precise control of facet properties.
The process Formula omitted is studied in the experiment at the VEPP-2000 Formula omitted collider with the SND detector. The technique of the time measurements in the multichannel NaI(Tl) ...electromagnetic calorimeter is used to select Formula omitted events. The value of the measured cross section in the center-of-mass energy range from 1.894 to 2 GeV varies from 0.5 to 0.35 nb. The effective neutron timelike form factor is derived from the measured cross section and compared with the proton form factor. The ratio of the neutron electric and magnetic form factors is obtained from the analysis of the antineutron polar angle distribution and found to be consistent with unity.
Semimetal bismuth with plasmonic properties has attracted more and more interest to enhance photocatalytic activity. Herein Bi/Bi.sub.2WO.sub.6 composites catalyst was successfully synthesized via a ...simple two-step route in solvothermal reaction. Compared with pure Bi.sub.2WO.sub.6, the photocatalytic degradation efficiency of gasphase toluene of the Bi/Bi.sub.2WO.sub.6 composites is significantly increased from 44 to 93%, and the degradation efficiency increased by more than two times. From the analysis of UV-vis diffuse reflectance spectra, it is obvious that the optical absorption in visible light region of Bi/Bi.sub.2WO.sub.6 composites has significantly enhanced compared to pure Bi.sub.2WO.sub.6, which is due to the surface plasmon resonance (SPR) of Bi nanoparticles on the surface of pure Bi.sub.2WO.sub.6. The dramatically enhanced activity could be attributed to the synergistic effect of the strong SPR of Bi metals and the enhancement of charge separation efficiency caused by the interfacial interaction between Bi metal and Bi.sub.2WO.sub.6.
Purpose The tissue-to-plasma partition coefficient (K.sub.p) describes the extent of tissue distribution in physiologically-based pharmacokinetic (PBPK) models. Constant-rate infusion studies are ...common for experimental determination of the steady-state K.sub.p,ss, while the tissue-plasma concentration ratio (C.sub.T/C.sub.p) in the terminal phase after intravenous doses is often utilized. The Chen and Gross (C&G) method converts a terminal slope C.sub.T/C.sub.p to K.sub.p,ss based on assumptions of perfusion-limited distribution in tissue-plasma equilibration. However, considering blood flow (Q.sub.T) and apparent tissue permeability (f.sub.upPS.sub.in) in the rate of tissue distribution, this report extends the C&G method by utilizing a fractional distribution parameter (f.sub.d). Methods Relevant PBPK equations for non-eliminating and eliminating organs along with lung and liver were derived for the conversion of C.sub.T/C.sub.p values to K.sub.p,ss. The relationships were demonstrated in rats with measured C.sub.T/C.sub.p and K.sub.p,ss values and the model-dependent f.sub.d for 8 compounds with a range of permeability coefficients. Several methods of assessing K.sub.p were compared. Results Utilizing f.sub.d in an extended C&G method, our estimations of K.sub.p,ss from C.sub.T/C.sub.p were improved, particularly for lower permeability compounds. However, four in silico methods for estimating K.sub.p performed poorly across tissues in comparison with measured K.sub.p values. Mathematical relationships between K.sub.p and K.sub.p,ss that are generally applicable for eliminating organs with tissue permeability limitations necessitates inclusion of an extraction ratio (ER) and f.sub.d. Conclusion Since many different types/sources of K.sub.p are present in the literature and used in PBPK models, these perspectives and equations should provide better insights in measuring and interpreting K.sub.p values in PBPK.
The current research describes the synthesis and characterization of 2-acetylpyridine N(4)-cyclohexyl-thiosemicarbazone ligand (HL) and their two metal complexes, Au(L)ClAuClsub.2 (1) and Pd(L)Cl·DMF ...(2). The molecular structures of the compounds were determined by physicochemical and spectroscopic methods. Single crystal X-ray diffraction was employed in the structural elucidation of the new complexes. The complexes showed a square planar geometry to the metal center Au(III) and Pd(II), coordinated with a thiosemicarbazone molecule by the NNS-donor system and a chloride ion. Complex (1) also shows the AuClsub.2sup.− counter-ion in the asymmetric unit, and complex (2) has one DMF solvent molecule. These molecules play a key role in the formation of supramolecular structures due to different interactions. Noncovalent interactions were investigated through the 3D Hirshfeld surface by the dnorm function and the 2D fingerprint plots. The biological activity of the compounds was evaluated in vitro against the human glioma U251 cells. The cytotoxicity results revealed great antitumor activity in complex (1) compared with complex (2) and the free ligand. Molecular docking simulations were used to predict interactions and properties with selected proteins and DNA of the synthesized compounds.
We propose to search for the open heavy-flavor exotic states with the quark components of Formula omitted with Formula omitted via their weak decays. If there exist such exotic states below the BK or ...DK thresholds, they can only decay weakly. The advantages include: (i) the experimental backgrounds from the secondary decay vertex are much lower due to the long lifetimes, (ii) the productions are large enough for only one heavy quark in such states, (iii) the thresholds of BK or DK are about 260 MeV higher compared to the Formula omitted or Formula omitted thresholds of the configurations of Formula omitted or Formula omitted, with a higher possibility to exist such weakly-decay particles, and (iv) if observed, their inner structures are easier understood since they can not be induced by the kinematic effects.
Impregnation solutions for the preparation of NTA-modified CoMo/Al.sub.2O.sub.3 hydrodesulfurization catalysts were prepared without use of unnecessary and disrupting NH.sub.4.sup.+ and ...NO.sub.3.sup.- ions. The reaction-dissolution took place in the suspension of NTA, CoCO.sub.3·xH.sub.2O and MoO.sub.3 (here DISUSPEN method). The conventional solutions, prepared in the literature using NTA, NH.sub.4OH, MoO.sub.3 and Co(NO.sub.3).sub.2, (here DISAMON method), were neutral or basic. The solid obtained by their drying was partly crystalline. The DISUSPEN solutions were acidic, with pH = 1.0-1.5. The DISUSPEN solids were XRD-amorphous with glass-like appearance. Much less nitrogen-containing emissions is produced during in-situ sulfidation of DISUSPEN catalysts as compared with DISAMON catalysts. Catalysts prepared by the DISUSPEN method are more active in HDS of thiophene than those prepared by the conventional DISAMON method.
The orientation and magnitude of the molecular electric dipole moment are key properties relevant to topics ranging from the nature of intermolecular interactions to the quantitative analysis of ...complex gas-phase mixtures, such as chemistry in astrophysical environments. Stark effect measurements on rotational spectra have been the method of choice for isolated molecules but have become less common with the practical disappearance of Stark modulation spectrometers. Their role has been taken over by supersonic expansion measurements within a Fabry-Perot resonator cavity, which introduces specific technical problems that need to be overcome. Several of the adopted solutions are described and compared. Presently, we report precise electric dipole moment determinations for the two most stable conformers of the selected molecules of confirmed or potential astrophysical relevance: n-propanol, n-butanol, and n-butyl cyanide. All dipole moment components have been precisely determined at supersonic expansion conditions by employing specially designed Stark electrodes and a computer program for fitting the measured Stark shifts, inclusive of cases with resolved nuclear quadrupole hyperfine structure. The experimental values are compared with suitable quantum chemistry computations. It is found that, among the tested levels of computation, vibrationally averaged dipole moments are the closest to the observation and the molecular values are, as in the lighter molecules in the series, largely determined by the hydroxyl or nitrile groups.
A study of the behavior of NB-IoT wireless communication in an industrial indoor environment was conducted in this paper. With Wireless Insite software, a scenario in the industrial sector was ...simulated and modeled. Our research examined how this scenario or environment affected the communication parameters of NB-IoT's physical layer. In this context, throughput levels among terminals as well as between terminals and transceiver towers, the power received at signal destination points, signal-to-noise ratios (SNRs) in the environment, and distances between terminals and transceivers are considered. These simulated results are also compared with the calculated or theoretical values of these parameters. The results show the effect of the industrial setting on wireless communication. The differences between the theoretical and simulated values are also established.
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