A round 7.4 million people in the UK have heart and cardiovascular disease, coronary artery disease (CAD) being the most common type. The Driving and Vehicle Licensing Agency (DVLA) has guidance for ...medical professionals to aid assessment of cardiac patients with respect to driving. The guidance is different for personal, Public Carriage Office (PCO) and goods vehicles. It remains the doctors’ responsibility to advise patients of any driving restrictions, as certain cardiac conditions can limit patients’ ability to drive. This gains importance especially after certain procedures. A retrospective review of discharge summaries from electronic medical records was undertaken for a period of three months to review the number of patients getting appropriate advice. It was noted that frequently no written driving advice was recorded on discharge, neglecting an important element of patient safety. Steps were taken to counteract the lack of proper driving advice and documentation, which were effective on second review. Therefore, measures similar to ones outlined here should be put in place to ensure safe discharge and knowledge of the clinicians in accordance with the DVLA guidance.
Endorsement date
21 January 2021
Implementation date
27 March 2021
Following the adoption of Regulation (EU) 2015/2283 on novel foods, the European Commission requested EFSA develop scientific and ...technical guidance for the preparation and submission of applications for authorisation of novel foods. This guidance presents a common format for the organisation of the information to be presented by the applicant when preparing a well‐structured application to demonstrate the safety of the novel food. It outlines the data needed for the safety assessments of novel foods. Requirements relate to the description of the novel food, production process, compositional data, specification, proposed uses and use levels, and anticipated intake of the novel food. Further sections on the history of use of the novel food and/or its source, absorption, distribution, metabolism, excretion, nutritional information, toxicological information and allergenicity should be considered by the applicant by default. If not covered in the application, this should be justified. The applicant should integrate the data presented in the different sections to provide their overall considerations on how the information supports the safety of the novel food under the proposed conditions of use. Where potential health hazards have been identified, they should be discussed in relation to the anticipated intakes of the novel food and the proposed target populations. On the basis of the information provided, EFSA will assess the safety of the novel food under the proposed conditions of use.
This guidance was originally adopted in 2016.It has beenrevised to informapplicants of the new provisions introduced by Regulation (EC) No 178/2002, as amended by Regulation (EU) 2019/1381 on the transparency and sustainability of the EU risk assessment in the food chain.This revised guidance applies to all dossiers submitted as of 27 March 2021. The 2016 version of this guidance remains applicable to applications submitted before 27 March 2021.
A unified optimal guidance scheme is presented in this paper for both midcourse and terminal phases combined. It minimizes the total deceleration resulting in enhanced range and/or higher impact ...velocity, while satisfying the terminal constraints on impact angle and miss distance. State-dependent terms are included in the cost function of the recently-proposed Generalized QS-MPSP and, because of its similarity with the Pseudo-Spectral philosophy, it is renamed as 'Pseudo-Spectral MPSP'. Extensive simulation studies with different engagement scenarios illustrate the effectiveness of the proposed guidance to engage with incoming high-speed ballistic targets.
Is management a profession? Should it be? Can it be? This major work of social and intellectual history reveals how such questions have driven business education and shaped American management and ...society for more than a century. The book is also a call for reform. Rakesh Khurana shows that university-based business schools were founded to train a professional class of managers in the mold of doctors and lawyers but have effectively retreated from that goal, leaving a gaping moral hole at the center of business education and perhaps in management itself. Khurana begins in the late nineteenth century, when members of an emerging managerial elite, seeking social status to match the wealth and power they had accrued, began working with major universities to establish graduate business education programs paralleling those for medicine and law. Constituting business as a profession, however, required codifying the knowledge relevant for practitioners and developing enforceable standards of conduct. Khurana, drawing on a rich set of archival material from business schools, foundations, and academic associations, traces how business educators confronted these challenges with varying strategies during the Progressive era and the Depression, the postwar boom years, and recent decades of freewheeling capitalism.
During nervous system development, neurons extend axons to reach their targets and form functional circuits. The faulty assembly or disintegration of such circuits results in disorders of the nervous ...system. Thus, understanding the molecular mechanisms that guide axons and lead to neural circuit formation is of interest not only to developmental neuroscientists but also for a better comprehension of neural disorders. Recent studies have demonstrated how crosstalk between different families of guidance receptors can regulate axonal navigation at choice points, and how changes in growth cone behaviour at intermediate targets require changes in the surface expression of receptors. These changes can be achieved by a variety of mechanisms, including transcription, translation, protein-protein interactions, and the specific trafficking of proteins and mRNAs. Here, I review these axon guidance mechanisms, highlighting the most recent advances in the field that challenge the textbook model of axon guidance.
The twenty-one all new chapters in this second edition poignantly review a variety of different careers designed for individuals undecided about their future, beyond a desire or a calling to work ...with people, and provide excellent cutting edge information about a large variety of human service professions and occupations, wrapped in the authors real passion for helping people. Part I discusses some of the tangible and intrinsic reasons why people want to be human service professionals, and defines and discusses career choice and human service, as well as the concepts of career, job and professionalism. Part II includes 18 chapters each authored by an all-star team of 30 professionals with many years of service delivery experience and accomplished scholars, who hold or have held numerous leadership positions in, and have taught many graduate courses in, their respective professional disciplines. Each of the 18 chapters addresses 10 specific aspects of human service professions. Part III presents a brief overview of five major occupational areas where individuals with non-graduate degrees frequently find employment working with people. Within each area, specific jobs are described and salary and outlook information given. Part IV offers an in-depth discussion of professionalism in human services, defines and addresses the big four human service regulatory mechanisms: certification, licensure, registration and accreditation, and discusses autonomy, professional behavior, codes of ethics, the roles of knowledge in decision-making and professionals ultimate decisions, and the importance of professional self-concept. This book, designed as a textbook for undergraduate courses in human services, is a must read for the young-and-eager or the mature second-careerist future human service professional. The thoughtful, knowledgeable, practical
and cutting-edge approaches in this book provide an invaluable point of embarkation on anyones journey to a personally and professionally rewarding career as a human service professional.
This article introduces a new methodology for designing guidance laws that directly shape the pattern of the heading error as desired. To this end, the concept of generalized finite-time convergence ...error dynamics is introduced. By leveraging this specific error dynamics, the proposed guidance laws can ensure that the heading error decreases according to the desired pattern while guaranteeing finite-time convergence. The resulting guidance laws take the form of proportional navigation guidance laws, but with a previously unexplored time-varying gain. This article conducts a theoretical analysis to examine the properties of the proposed guidance laws, including the closed-form solutions of the heading error and acceleration command. Compared to the existing methods, the proposed guidance laws provide a more direct and versatile approach to addressing various guidance operational goals. Accordingly, several illustrative examples are presented to demonstrate the process of designing guidance laws using the proposed approach. Furthermore, numerical simulations are conducted to validate the characteristics of the designed guidance laws.
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