The fast-changing world of work has justified the need for contemporary, accessible and inclusive models of lifelong guidance, underpinned by principles of social justice and equity, that meet a ...range of needs, and have the ambition of leaving no one behind. While guidance provision is widely available across most education systems, guidance for the labour force is less accessible and often fragmented, varying in quality, scope, evidence-base and practice. For services to be fully effective adult and employment guidance practice must find ways to transfer knowledge and experiences of the daily practice of guidance, to advance professional learning and development, and ensure its assimilation into practice and policy for the benefit of clients. Drawing on qualitative data, this paper illustrates the role of praxis in informing a new model of employment guidance, the MEEG, and the challenges for adult guidance practice within activation-oriented public employment systems.
Radiation therapy (RT) continues to play an important role in the treatment of cancer. Adaptive RT (ART) is a novel method through which RT treatments are evolving. With the ART approach, computed ...tomography or magnetic resonance (MR) images are obtained as part of the treatment delivery process. This enables the adaptation of the irradiated volume to account for changes in organ and/or tumor position, movement, size, or shape that may occur over the course of treatment. The advantages and challenges of ART maybe somewhat to oncologists and clinicians outside of the specialty of radiation oncology. ART is positioned to affect many different types of cancer. There is a wide spectrum of hypothesized benefits, from small toxicity improvements to meaningful gains in overall survival. The use and application of this novel technology should be understood by the oncologic community at large, such that it can be appropriately contextualized within the landscape of cancer therapies. Likewise, the need to test these advances is pressing. MR‐guided ART (MRgART) is an emerging, extended modality of ART that expands upon and further advances the capabilities of ART. MRgART presents unique opportunities to iteratively improve adaptive image guidance. However, although the MRgART adaptive process advances ART to previously unattained levels, it can be more expensive, time‐consuming, and complex. In this review, the authors present an overview for clinicians describing the process of ART and specifically MRgART.
A cooperative salvo guidance strategy using fixed finite-time consensus is proposed here. The consensus algorithm is based on sliding mode control. The cooperative salvo attack problem is transformed ...to a consensus problem over a cycle digraph. This aids in designing a guidance strategy through selection of heterogeneous gains. The proposed strategy guarantees convergence to a common impact time for all the interceptors, within a fixed time, from a wide range of initial heading angles. Subsequently, the guidance strategy is extended to cooperatively intercept a constant velocity target. The efficacy of the proposed algorithm is vindicated through simulations on both stationary and constant velocity targets. Numerical simulations are also performed on realistic missile models that account for aerodynamic parameter variations, yielding satisfactory performance.
The problem of Impact Time Control Guidance (ITCG) with field-of-view (FOV) constraint is investigated. The proposed ITCG law is a combination of the well-known Proportional Navigation Guidance (PNG) ...law and an additional biased term of impact time error, which is defined as the difference between the impact time by PNG and the prescribed one. A rule of the cosine of weighted leading angle in the biased term is used to guarantee that the FOV constraint is not violated during the engagement. Stability of the closed-loop guidance system is proved strictly. Numerical simulation results are presented to demonstrate the effectiveness of the proposed guidance law.
In this article, an incremental guidancelaw with terminal angle constraint is proposed against maneuvering targets in the 3-D space. First, a sliding surface is constructed such that its first-order ...dynamics excludes the relative range and line-of-sight angles in the perturbation. This manipulation avoids unboundedperturbations induced by target maneuvers near collision. Then, a benchmark guidance law is derived via the nonlinear dynamic inversion (NDI) based sliding mode control (NDI-SMC). To further enhance guidance system robustness, an incremental nonlinear dynamic inversion (INDI) based SMC (INDI-SMC) 3-D guidance law is developed. The INDI-SMC guidance law exploits the first-order derivative of the sliding variable and guidance command output at the latest step, which leads to reduced perturbation and thus requires smaller gains than the NDI-SMC guidance law. A multivariable continuous differentiator is employed to estimate the sliding variable's first-order derivative for guidance law implementation. Moreover, the stability of the differentiator is analyzed and the guidance robustness under uncertainties is compared. Extensive numerical simulations and a Monte Carlo test are conducted to verify effectiveness and robustness of the proposed method.
The book 'PROFESSIONALS AND CAREERS IN COMPUTER SCIENCE AND TECHNOLOGY' seeks to answer the question of what can you do with a computer science degree? The scope of computer science continues to ...expand, which means you can choose from a variety of very specialized fields. Computer technology is an integral part of modern life, so you are likely to find a high demand for computer science skills in many different sectors. These include financial organizations, management consulting companies, software companies, communications corporations, data warehouses, multinational companies, government agencies, colleges and hospitals. In addition to computer science, the book teaches students technical and non-technical skills that are highly appreciated by employers, from team leadership to programming.
This paper presents an impact time control guidance law that does not perform explicit time-to-go estimation. In order to satisfy the interception and the desired impact time constraint ...simultaneously, a sliding surface variable formulated as a sum of the relative range and the desired time-to-go is defined, weighted by two nonzero weighting functions. Then, the achievement of the sliding mode satisfies the following equivalence: The relative range is zero if and only if the elapsed time equals to the desired impact time. It means that both the interception and impact time control can be satisfied at the same time in the sliding mode. The impact time control guidance law is derived to enforce the defined surface variable to the sliding mode. Because the law is designed based on the capture condition without separate time-to-go estimation process, the achievement of the sliding mode always guarantees the interception of the target at the desired impact time. In addition, the proposed law can be applied to an engagement considering nonstationary targets in a straightforward manner because the corresponding time-to-go estimation is not needed. Simulation results demonstrate that the proposed guidance law has better performance in comparison with the existing guidance law, in respect of satisfying the desired impact time constraint against a nonstationary target.
Amyotrophic Lateral Sclerosis (ALS) is being redefined as a distal axonopathy, in that many molecular changes influencing motor neuron degeneration occur at the neuromuscular junction (NMJ) at very ...early stages of the disease prior to symptom onset. A huge variety of genetic and environmental causes have been associated with ALS, and interestingly, although the cause of the disease can differ, both sporadic and familial forms of ALS show a remarkable similarity in terms of disease progression and clinical manifestation. The NMJ is a highly specialized synapse, allowing for controlled signaling between muscle and nerve necessary for skeletal muscle function. In this review we will evaluate the clinical, animal experimental and cellular/molecular evidence that supports the idea of ALS as a distal axonopathy. We will discuss the early molecular mechanisms that occur at the NMJ, which alter the functional abilities of the NMJ. Specifically, we focus on the role of axon guidance molecules on the stability of the cytoskeleton and how these molecules may directly influence the cells of the NMJ in a way that may initiate or facilitate the dismantling of the neuromuscular synapse in the presymptomatic stages of ALS.
In an effort to pursue more advanced missions in space, improved on-board trajectory optimization and path (re)planning capabilities are necessary. Over the past decades, numerous missions have ...pushed the state of the art in autonomous rendezvous and proximity operations (RPOs). Regardless of the mission, any RPO guidance algorithm must be able to react to a dynamic environment while generating a fuel-efficient trajectory. An adaptive artificial potential function (AAPF) guidance exhibiting these properties has been experimentally evaluated on a spacecraft air-bearing test bed and its performance compared to traditional APF and other real-time guidance methods.
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